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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.48 no.1 São Paulo Mar. 1990

http://dx.doi.org/10.1590/S0004-282X1990000100007 

Timectomia e imunossupressão em miastenia gravis estudo prospectivo

 

Thymectomy and immunessupression in myasthenia gravis: a prospective study

 

 

Marcos C. SandmannI; Ana M. GorzI; Cleverson M. GraciaI; Randas J. V. BatistaII; Ricardo Ranieri SeixasIII; Paulo Rogério M. BittencourtI

IUnidade de Neurologia Clínica - Hospital Nossa Senhora das Graças, Curitiba
IICentro de Cardiologia de Curitiba - Hospital Nossa Senhora das Graças, Curitiba
IIIUnidade de Neurofisiologia Clinica - Hospital Nossa Senhora das Graças, Curitiba

 

 


RESUMO

Entre 1982 e 1988 24 mulheres e 6 homens com miastenia gravis foram submetidos a protocolo diagnóstico e terapêutico prospectivo e estandardizado. A idade variou de 10 a 74 anos (34±16, média±desvio padrão). Três com forma ocular foram tratados com piridostigmina. Quatro com forma generalizada, de idade avançada, receberam corticosteróide e/ou azatioprina. Vinte e três com a forma generalizada foram submetidos a timectomia seguida de prednisona e/ou azatioprina. Um paciente faleceu após timectomia complexa de timoma invasivo. Qutro faleceu logo após a admissão, em crise miastênica/colinérgica. Dois outros tiveram complicações menores da timectomia. De 19 pacientes seguidos por 1-60 (média 24) meses, 11 (58%) têm fraqueza residual mas levam vida normal e 8 (42%) estão em remissão completa, um sem medicação.


SUMMARY

Between 1982 and 1988 24 women and 6 men with myasthenia gravis were included in a prospective and standardized diagnostic and therapeutic protocol. Age varied between 10 and 74 years (34 ± 16, mean ± standard deviation). Three patients with the ocular form were treated with pyridostigmine. Four patients with the generalized form and advanced age received steroids and/or azathioprine. Twenty-three patients with the generalized form underwent thymectomy followed by prednisone and/or azathioprine. One patient died after complex thymectomy for invasive thymoma. Another died soon after admission in myasthenic/cholinergic crisis. Two other patients had minor complications of thymectomy. Of 19 patients followed for 1-60 (mean 24) months, 11 (58%) are in remission, one of them without any medication.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Dr. Paulo Rogério M. Bittencourt - Unidade de Neurologia Clínica, Hospital Nossa Senhora das Graças - Rua Alcides Munhoz 433 - 80510 Curitiba PR - Brasil

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