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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.48 no.1 São Paulo Mar. 1990

http://dx.doi.org/10.1590/S0004-282X1990000100008 

Estudo da correlação hla em uma população e miastenia gravis brasileira

 

HLA and myasthenia gravis: a Brazilian population study.

 

 

Elza Dias-TostaI; Rubens N. Morato-FernandezII; José A. VillaçaIII

IPh.D., Neurologista, Hospital Docente Assistêncial de Brasilia (HDA)
IINeurologista, atualmente no Hospital de Doenças do Aparelho Locomotor/SARAH, Brasília
IIIHematologísta, responsável pelo Laboratório de Histocompatibilidade do HDA

 

 


RESUMO

Sabendo-se da miscigenação da população brasileira, o que a diferencia de caucasianos, amarelos ou negros americanos, os autores estudaram a correlação HLA e miastenia gravis em 37 pacientes e os compararam com o grupo controle estudado no mesmo laboratório, composto de 69 indivíduos normais. Foi encontrado um risco relativo (RR) estatisticamente significante para HLA B8 em pacientes jovens do sexo feminino. Também alto foi o RR para B8 no grupo com hyperplasia tímica e de Al e B8, para o grupo da raça negra.


SUMMARY

Based on the fact that Brazilian ethnic groups are mixed and therefore different from Caucasian, Chinese or japanese populations the authors studied the HLA antigen distribution in 37 myasthenic patients. The control group consisted of 69 healthy individuals of the same population studied in the same laboratory. The antigens HLA B8 showed the highest relative risk for female, younger than 40 years old, with thymic hyperplasia. Also the HLA B8 and A1 showed high frequency for black myasthenic patients.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Dra. Elza Dias-Tosta - SHIS, QL 16, Conjunto 5, Casa 17 - 71600 Brasília DF - Brasil

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