Estudo da correlação hla em uma população e miastenia gravis brasileira

Dias-Tosta, Elza; Morato-Fernandez, Rubens N.; Villaça, José A.

doi:10.1590/S0004-282X1990000100008

Resumos

Sabendo-se da miscigenação da população brasileira, o que a diferencia de caucasianos, amarelos ou negros americanos, os autores estudaram a correlação HLA e miastenia gravis em 37 pacientes e os compararam com o grupo controle estudado no mesmo laboratório, composto de 69 indivíduos normais. Foi encontrado um risco relativo (RR) estatisticamente significante para HLA B8 em pacientes jovens do sexo feminino. Também alto foi o RR para B8 no grupo com hyperplasia tímica e de Al e B8, para o grupo da raça negra.

Based on the fact that Brazilian ethnic groups are mixed and therefore different from Caucasian, Chinese or japanese populations the authors studied the HLA antigen distribution in 37 myasthenic patients. The control group consisted of 69 healthy individuals of the same population studied in the same laboratory. The antigens HLA B8 showed the highest relative risk for female, younger than 40 years old, with thymic hyperplasia. Also the HLA B8 and A1 showed high frequency for black myasthenic patients.

Elza Dias-Tosta^I; Rubens N. Morato-Fernandez^II; José A. Villaça^III

^IPh.D., Neurologista, Hospital Docente Assistêncial de Brasilia (HDA)

^IINeurologista, atualmente no Hospital de Doenças do Aparelho Locomotor/SARAH, Brasília

^IIIHematologísta, responsável pelo Laboratório de Histocompatibilidade do HDA

RESUMO

Sabendo-se da miscigenação da população brasileira, o que a diferencia de caucasianos, amarelos ou negros americanos, os autores estudaram a correlação HLA e miastenia gravis em 37 pacientes e os compararam com o grupo controle estudado no mesmo laboratório, composto de 69 indivíduos normais. Foi encontrado um risco relativo (RR) estatisticamente significante para HLA B8 em pacientes jovens do sexo feminino. Também alto foi o RR para B8 no grupo com hyperplasia tímica e de Al e B8, para o grupo da raça negra.

SUMMARY

Based on the fact that Brazilian ethnic groups are mixed and therefore different from Caucasian, Chinese or japanese populations the authors studied the HLA antigen distribution in 37 myasthenic patients. The control group consisted of 69 healthy individuals of the same population studied in the same laboratory. The antigens HLA B8 showed the highest relative risk for female, younger than 40 years old, with thymic hyperplasia. Also the HLA B8 and A1 showed high frequency for black myasthenic patients.

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Dra. Elza Dias-Tosta - SHIS, QL 16, Conjunto 5, Casa 17 - 71600 Brasília DF - Brasil

1. Christiansen FT, Pollack MS, Garlepp MJ, Dawkins RL - Myasthenia gravis and HLA antigens in American blacks and other races. J Neuroimmunol 7:121, 1984.
2. Compston DAS, Vincent A, Newson-Davis J, Batchelor JR - Clinical, pathological HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 103:579, 1980.
3. Dausset J - HLA et maladies. Rev Bras Pesa Méd Biol 11:147, 1978.
4. Dias-Tosta E, Morato-Fernandes RN - Miastenia grave: tratamento com timectomia, cortlcóide e plasmaferese. Arq Neuro-Psiquiat (São Paulo) 47:39, 1989.
5. Fritze D, Herrman C Jr, Naeim F, Smith GS, Walford RL - HLA antigens in myasthenia gravis. Lancet 1:240, 1974.
6. Hawkins BK, Ip MSM, Lam KSL, Ma JTC, Chan-Lui WY, Yeung RTT, Dawkins RL - HLA antigens and acetylcholine receptor antibody in the subclassification of myasthenia gravis in Hone Kong Chinese. J Neurol Neurosurg Psychiat 49:316, 1986.
7. Keesey J, Naiem F, Lindstron J, Roe D, Herrmann C Jr, Walford R - Acetylcholine receptor antibody titer and HLA-B8 antigen in myasthenia gravis. Arch Neurol 39:73, 1982.
8. Mehra NK, Ahuia GK, Taneia V, Vaidya MC - HLA antigens and myasthenia gravis in North India. J Neurol Neurosurg Psychiat 46:361, 1983.
9. Michels VV, Dyck PJ - Mendelian inheritance and basis of classification of hereditary neuropathy with neuronal atrophy and degeneration. In Dyck PJ et al (eds): Peripheral Neuropathy. Saunders, Philadelphia, 1984.
10. Pirskanen R - Genetic associations between myasthenia gravis and the HLA system. J Neurol Neurosurg Psychiat 39:23, 1976.
11. Yoshida T, Tsuchiya M, Ono A, Yashimatsu H, Satoyoshi E, Tsuji K - HLA antigens and myasthenia gravis in Japan. J Neurol Sci 32:195. 1977.

Estudo da correlação hla em uma população e miastenia gravis brasileira

HLA and myasthenia gravis: a Brazilian population study.

Datas de Publicação

Publicação nesta coleção
25 Maio 2011
Data do Fascículo
Mar 1990

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Christiansen FT, Pollack MS, Garlepp MJ, Dawkins RL - Myasthenia gravis and HLA antigens in American blacks and other races. J Neuroimmunol 7:121, 1984.

[2] 2. Compston DAS, Vincent A, Newson-Davis J, Batchelor JR - Clinical, pathological HLA antigen and immunological evidence for disease heterogeneity in myasthenia gravis. Brain 103:579, 1980.

[3] 3. Dausset J - HLA et maladies. Rev Bras Pesa Méd Biol 11:147, 1978.

[4] 4. Dias-Tosta E, Morato-Fernandes RN - Miastenia grave: tratamento com timectomia, cortlcóide e plasmaferese. Arq Neuro-Psiquiat (São Paulo) 47:39, 1989.

[5] 5. Fritze D, Herrman C Jr, Naeim F, Smith GS, Walford RL - HLA antigens in myasthenia gravis. Lancet 1:240, 1974.

[6] 6. Hawkins BK, Ip MSM, Lam KSL, Ma JTC, Chan-Lui WY, Yeung RTT, Dawkins RL - HLA antigens and acetylcholine receptor antibody in the subclassification of myasthenia gravis in Hone Kong Chinese. J Neurol Neurosurg Psychiat 49:316, 1986.

[7] 7. Keesey J, Naiem F, Lindstron J, Roe D, Herrmann C Jr, Walford R - Acetylcholine receptor antibody titer and HLA-B8 antigen in myasthenia gravis. Arch Neurol 39:73, 1982.

[8] 8. Mehra NK, Ahuia GK, Taneia V, Vaidya MC - HLA antigens and myasthenia gravis in North India. J Neurol Neurosurg Psychiat 46:361, 1983.

[9] 9. Michels VV, Dyck PJ - Mendelian inheritance and basis of classification of hereditary neuropathy with neuronal atrophy and degeneration. In Dyck PJ et al (eds): Peripheral Neuropathy. Saunders, Philadelphia, 1984.

[10] 10. Pirskanen R - Genetic associations between myasthenia gravis and the HLA system. J Neurol Neurosurg Psychiat 39:23, 1976.

[11] 11. Yoshida T, Tsuchiya M, Ono A, Yashimatsu H, Satoyoshi E, Tsuji K - HLA antigens and myasthenia gravis in Japan. J Neurol Sci 32:195. 1977.