Brain tumours in south Brazil a retrospective study of 438 cases

Torres, Luiz Fernando Bleggi; Almeida, Renata; Avila, Sandra; Alessi, Silvoney; Freitas, Renato

doi:10.1590/S0004-282X1990000300003

Abstracts

All brain tumours diagnosed since 1967 in a University Hospital in the Southern region of Brazil were reviewed and clinical information concerning age, sex, symptoms and evolution were analysed. 88.1% of tumours were primary neoplasms and the rest secondary deposits. There was a male predominance and the second and fifth decades of life were the most affected. The main presenting symptoms were headache, vomiting, hemiparesis, loss of vision and epilepsy. The commonest tumour was of astrocytic origin (36.3%) amongst which the malignant ones, including glioblastoma multiforme, predominated. These tumours were frequent in the cerebral hemispheres (31.3%), particularly in the frontal lobes. The time of evolution from the beginning of the clinical manifestations until the first hospital admission was also studied. The authors discuss the clinical and pathological observations in relation to other large series analysed in the literature.

Todos os tumores diagnosticados no Hospital de Clínicas da Universidade Federal do Paraná desde 1967 até o final de 1988 foram revistos e informações clínicas sobre idade, sexo, sintomas e evolução foram comparados aos tipos histológicos. 88,1% dos tumores corresponderam a neoplasias primárias e o restante a metastases. Verificou-se predominância de acometimento no sexo masculino e nas segunda e quinta déeadas de vida. Os sintomas principais foram cefaléia, vômitos, hemiparesia, perda de visão e epilepsia. Os tumores mais freqüentes corresponderam aos de origem astrocitária (36,3%) destacando-se o glioblastoma multiforme. Estes tumores acometeram hemisférios cerebrais (31,3%), particularmente os lobos frontais. O tempo de evolução desde o início das manifestações clínicas até a primeira admissão hospitalar foi também estudado. Neoplasias malignas, como glioblastoma e meduloblastoma, têm evolução rápida enquanto meningeomas podem levar anos para manifestarem-se clinicamente. Os autores comparam suas observações clínicas e histopatológicas com outras grandes séries estudadas na literatura.

Brain tumours in south Brazil a retrospective study of 438 cases

Tumores cerebrais em região sul do Brasil: estudo retrospectivo de 438 casos

Luiz Fernando Bleggi Torres^I; Renata Almeida^II; Sandra Avila^II; Silvoney Alessi^II; Renato Freitas^II

^IM.D., Ph.D. (London), Professor Adjunto - Departamento de Patologia Médica, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba

^IIAcadêmico Estagiário - Departamento de Patologia Médica, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba

SUMMARY

All brain tumours diagnosed since 1967 in a University Hospital in the Southern region of Brazil were reviewed and clinical information concerning age, sex, symptoms and evolution were analysed. 88.1% of tumours were primary neoplasms and the rest secondary deposits. There was a male predominance and the second and fifth decades of life were the most affected. The main presenting symptoms were headache, vomiting, hemiparesis, loss of vision and epilepsy. The commonest tumour was of astrocytic origin (36.3%) amongst which the malignant ones, including glioblastoma multiforme, predominated. These tumours were frequent in the cerebral hemispheres (31.3%), particularly in the frontal lobes. The time of evolution from the beginning of the clinical manifestations until the first hospital admission was also studied. The authors discuss the clinical and pathological observations in relation to other large series analysed in the literature.

RESUMO

Todos os tumores diagnosticados no Hospital de Clínicas da Universidade Federal do Paraná desde 1967 até o final de 1988 foram revistos e informações clínicas sobre idade, sexo, sintomas e evolução foram comparados aos tipos histológicos. 88,1% dos tumores corresponderam a neoplasias primárias e o restante a metastases. Verificou-se predominância de acometimento no sexo masculino e nas segunda e quinta déeadas de vida. Os sintomas principais foram cefaléia, vômitos, hemiparesia, perda de visão e epilepsia. Os tumores mais freqüentes corresponderam aos de origem astrocitária (36,3%) destacando-se o glioblastoma multiforme. Estes tumores acometeram hemisférios cerebrais (31,3%), particularmente os lobos frontais. O tempo de evolução desde o início das manifestações clínicas até a primeira admissão hospitalar foi também estudado. Neoplasias malignas, como glioblastoma e meduloblastoma, têm evolução rápida enquanto meningeomas podem levar anos para manifestarem-se clinicamente. Os autores comparam suas observações clínicas e histopatológicas com outras grandes séries estudadas na literatura.

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Dr. L. F. Bleggi Torres - Departamento de Patologia Médica, Hospital de Clinicas, UFPr -Rua General Carneiro 181 - 80059 Curitiba PR - Brasil.

1. Bancroft J, Stevens A - Theory and Practice of Histological Techniques. Churchill Livingston, Edinbourgh, 1982.
2. Becker LE, Hinton D - Primitive neuroectodermal tumors of the central nervous system. Human Pathol 14:538, 1983.
3. Becker LE, Yates AJ - Astrocytic tumors in children. In Finegold M (ed): Pathology of Neoplasia in Children and Adolescents. WB Saunders, Philadelphia, 1986, pg 373.
4. Bonnin JM, Rubinstein LJ - Immunohistochemistry of central nervous system tumors: its contribution to neurosurgical diagnosis. J Neurosurg 60:1121, 1984.
5. Chan RC, Thompson GB - Morbidity, mortality and quality of life following surgery for intracranial meningiomas: a retrospective study in 257 cases. J Neurosurg 60:52, 1984.
6. Cushing HW - Intracranial Tumors: Notes upon a Series of Two Thousand Verified Cases with Surgical-Mortality Percentages Pertaining Thereto. CC Thomas, Springfield, 1932.
7. Duifner PK, Cohen ME, Myers MH, Heise HW - Survival of children with brain tumors: SEER Program, 1973-1980. Neurology 36:597, 1986.
8. Fogelholm R, Uutela T, Murros K - Epidemiology of central nervous system neoplasms: a regional survey in Central Finland. Acta Neurol Scand 69:129, 1984.
9. Fulling KH, Nelson JS - Cerebral astrocytic neoplasms in the adult: contribution of histologic examination to the assessment of prognosis. Seminars in Diagnostic Pathology 1:152, 1984.
10. Grant FC - A study of the results of surgical treatment in 2326 consecutive patients with brain tumor. J Neurosurg 13:479, 1956.
11. Jellinger K, Slowik F - Histological subtypes and prognostic problems in meningiomas. J Neurol 208:279, 1975.
12. Katsura S, Suzuki J, Wada T - A statistical study of brain tumors in the neurosurgical clinics in Japan. J Neurosurg 16:570, 1959.
13. Kawano N, Yada K, Aihara M, Yashigita S - Oligodendroglioma-like cells (clear cells) in ependymoma. Acta Neuropathol (Berlin) 62:141, 1983.
14. Kepes JJ, Chen WYK, Pang LC, Kepes M - Tumors of the central nervous system in Taiwan, Republic of China. Surgical Neurol 22:149, 1984.
15. Lana-Peixoto MA, Pittella JEH, Arouca EMG - Primary intracranial tumors: analysis of a series of consecutive autopsies and biopsies. Arq Neuro-Psiquiat (São Paulo) 39:13, 1981.
16. Leetsma JE - Brain tumors. Am J Pathol 100:243, 1980.
17. Ludwig CL, Smith MT, Godfrey AD, Armbrustmacher VW - A clinicopathological study of 323 patients with oligodendrogliomas. Ann Neurol 19:15, 1986.
18. Polak J, van Noorden S - Immunocytochemistry. Wright, London, 1986.
19. Rubinstein LJ - Tumors of the Central Nervous System. Armed Forces Institute of Pathology, Washington DC, 1972.
20. Russell DS, Rubinstein LJ - Pathology of the Tumours of the Nervous System. Williams and Wilkins, Baltimore, 1977.
21. Sano K - Statistics on brain tumors and glioma. No To Shinkei 21:463, 1969.
22. Shuangshoti S, Panyathanya R - Neural neoplasms in Thailand: a study of 2897 cases. Neurology 24:1127, 1974.
23. Zulch KJ - Brain Tumors: their Biology and their Pathology. Ed 2. Springer-Verlag, New York, 1965.
24. Wen-qing H, Shi-ju Z, Quing-sheng T, Jian-qing H, Yu-xia L, Quing-zhong X, Zi-jun L, Wen-cui Z - Statiscal analysis of central nervous system tumors in China. J Neurosurg 56:555, 1982.
25. World Health Organization - Classification of Tumours of the Central Nervous System. WHO, Geneve, 1979.

Publication Dates

Publication in this collection
26 May 2011
Date of issue
Sept 1990

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Bancroft J, Stevens A - Theory and Practice of Histological Techniques. Churchill Livingston, Edinbourgh, 1982.

[2] 2. Becker LE, Hinton D - Primitive neuroectodermal tumors of the central nervous system. Human Pathol 14:538, 1983.

[3] 3. Becker LE, Yates AJ - Astrocytic tumors in children. In Finegold M (ed): Pathology of Neoplasia in Children and Adolescents. WB Saunders, Philadelphia, 1986, pg 373.

[4] 4. Bonnin JM, Rubinstein LJ - Immunohistochemistry of central nervous system tumors: its contribution to neurosurgical diagnosis. J Neurosurg 60:1121, 1984.

[5] 5. Chan RC, Thompson GB - Morbidity, mortality and quality of life following surgery for intracranial meningiomas: a retrospective study in 257 cases. J Neurosurg 60:52, 1984.

[6] 6. Cushing HW - Intracranial Tumors: Notes upon a Series of Two Thousand Verified Cases with Surgical-Mortality Percentages Pertaining Thereto. CC Thomas, Springfield, 1932.

[7] 7. Duifner PK, Cohen ME, Myers MH, Heise HW - Survival of children with brain tumors: SEER Program, 1973-1980. Neurology 36:597, 1986.

[8] 8. Fogelholm R, Uutela T, Murros K - Epidemiology of central nervous system neoplasms: a regional survey in Central Finland. Acta Neurol Scand 69:129, 1984.

[9] 9. Fulling KH, Nelson JS - Cerebral astrocytic neoplasms in the adult: contribution of histologic examination to the assessment of prognosis. Seminars in Diagnostic Pathology 1:152, 1984.

[10] 10. Grant FC - A study of the results of surgical treatment in 2326 consecutive patients with brain tumor. J Neurosurg 13:479, 1956.

[11] 11. Jellinger K, Slowik F - Histological subtypes and prognostic problems in meningiomas. J Neurol 208:279, 1975.

[12] 12. Katsura S, Suzuki J, Wada T - A statistical study of brain tumors in the neurosurgical clinics in Japan. J Neurosurg 16:570, 1959.

[13] 13. Kawano N, Yada K, Aihara M, Yashigita S - Oligodendroglioma-like cells (clear cells) in ependymoma. Acta Neuropathol (Berlin) 62:141, 1983.

[14] 14. Kepes JJ, Chen WYK, Pang LC, Kepes M - Tumors of the central nervous system in Taiwan, Republic of China. Surgical Neurol 22:149, 1984.

[15] 15. Lana-Peixoto MA, Pittella JEH, Arouca EMG - Primary intracranial tumors: analysis of a series of consecutive autopsies and biopsies. Arq Neuro-Psiquiat (São Paulo) 39:13, 1981.

[16] 16. Leetsma JE - Brain tumors. Am J Pathol 100:243, 1980.

[17] 17. Ludwig CL, Smith MT, Godfrey AD, Armbrustmacher VW - A clinicopathological study of 323 patients with oligodendrogliomas. Ann Neurol 19:15, 1986.

[18] 18. Polak J, van Noorden S - Immunocytochemistry. Wright, London, 1986.

[19] 19. Rubinstein LJ - Tumors of the Central Nervous System. Armed Forces Institute of Pathology, Washington DC, 1972.

[20] 20. Russell DS, Rubinstein LJ - Pathology of the Tumours of the Nervous System. Williams and Wilkins, Baltimore, 1977.

[21] 21. Sano K - Statistics on brain tumors and glioma. No To Shinkei 21:463, 1969.

[22] 22. Shuangshoti S, Panyathanya R - Neural neoplasms in Thailand: a study of 2897 cases. Neurology 24:1127, 1974.

[23] 23. Zulch KJ - Brain Tumors: their Biology and their Pathology. Ed 2. Springer-Verlag, New York, 1965.

[24] 24. Wen-qing H, Shi-ju Z, Quing-sheng T, Jian-qing H, Yu-xia L, Quing-zhong X, Zi-jun L, Wen-cui Z - Statiscal analysis of central nervous system tumors in China. J Neurosurg 56:555, 1982.

[25] 25. World Health Organization - Classification of Tumours of the Central Nervous System. WHO, Geneve, 1979.