INÍCIO DE CRISES EPILÉPTICAS NA MENARCA

Silveira, Diosely C.; Guerreiro, Carlos A.M.

doi:10.1590/S0004-282X1991000400011

Resumos

Nove pacientes com início das crises epilépticas coincidindo com a menarca foram avaliadas. Duas tinham crises generalizadas e 7 crises com início parcial. O exame físico e neurológico foram normais em todas, exceto em uma que tinha estenose aórtica. O EEG mostrou ondas agudas focais nas regiões temporais em 4 pacientes, ondas lentas intermitentes generalizadas em uma e foi normal nas outras 4. Sete das 9 pacientes que tiveram a primeira crise na menarca apresentavam exacerbação das crises epilépticas no período peri-menstrual, o que poderia sugerir estarem estas pacientes mais sujeitas a aumento na frequência das crises nesse período em ciclos subsequentes. Este achado necessita de estudo mais amplo para confirmação e pode contribuir para melhor orientação terapêutica nessas mulheres.

Nine patient whose epileptic seizures had began in the menarche phase were studied. Two of these patients had generalized seizures and seven partial seizures with or without generalization. The physical and neurologic exam was normal in all patients except one who had aortic stenosis. The EEG showed focal spikes in temporal regions in four patients, intermitent generalized slow waves in one and was normal in four patients. Seven of these patients complained of increasing of the seizure frequency near to the menstrual period. Data registered are discussed. It is concluded that the observation of a larger number of patients is necessary to confirm these data.

CONTENTS CONTEÚDO

Diosely C. Silveira^I; Carlos A.M. Guerreiro^II

^IProfessor Assistente - Departamento de Neurologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP)

^IIProfessor Assistente Doutor - Departamento de Neurologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP)

RESUMO

Nove pacientes com início das crises epilépticas coincidindo com a menarca foram avaliadas. Duas tinham crises generalizadas e 7 crises com início parcial. O exame físico e neurológico foram normais em todas, exceto em uma que tinha estenose aórtica. O EEG mostrou ondas agudas focais nas regiões temporais em 4 pacientes, ondas lentas intermitentes generalizadas em uma e foi normal nas outras 4. Sete das 9 pacientes que tiveram a primeira crise na menarca apresentavam exacerbação das crises epilépticas no período peri-menstrual, o que poderia sugerir estarem estas pacientes mais sujeitas a aumento na frequência das crises nesse período em ciclos subsequentes. Este achado necessita de estudo mais amplo para confirmação e pode contribuir para melhor orientação terapêutica nessas mulheres.

SUMMARY

Nine patient whose epileptic seizures had began in the menarche phase were studied. Two of these patients had generalized seizures and seven partial seizures with or without generalization. The physical and neurologic exam was normal in all patients except one who had aortic stenosis. The EEG showed focal spikes in temporal regions in four patients, intermitent generalized slow waves in one and was normal in four patients. Seven of these patients complained of increasing of the seizure frequency near to the menstrual period. Data registered are discussed. It is concluded that the observation of a larger number of patients is necessary to confirm these data.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Dr. Carlos Alberto Mantovani Guerreiro - Departamento de Neurologia, Faculdade de Ciências Médicas, UNICAMP - Caixa Postal 6111 - 13081 Campinas SP - Brasil.

1. Backstrom T, Zetterlund B, Blom S, Romano M. Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with parcial epilepsy. Acta Neurol Scand 1984, 69:240-248.
2. Bander B, Kaufman C, Dykens JW, Schleifer M, Shapiro LN. Seizures and the menstrual cycle. Am J Psychiat 1957, 113:704-708.
3. Costa PJ, Bonnycastle DD. The effect of DCA compound E, testosterone, progesterone and ACTH in modifying «agene-induced» convulsions in dogs. Arch Int Pharmacodyn 1952, 91:330-338.
4. Craig CR. Anticonvulsant activity of steroids: separability of anticonvulsant from hormonal effects. J Pharmacol Exp Ther 1966, 153:337-343.
5. Gowers WR. Epilepsy and Other Chronic Convulsive Disease: Their Causes, Symptons and Treatment. New York: William Wood, 1885.
6. Hardy RW. Unit activity in premarin-induced cortical epileptogenic foci. Epilepsia 1970, 11:179-186.
7. Heim LM. Effect of estradiol on brain maturation: dose and time response relationships. Endocrinology 1966, 78:1130-1134.
8. Helmchen H, Kunkel H, Selbach H. Periodische Einflusse auf die individuale Haufigkeit cerebraler Anfalle. Arch Psychiat Nervenkr 1964, 206:293-308.
9. Holmes GL, Weber DA. The effect of progesterone on kindling: a developmental study. Dev Brain Res 1984, 16:45-53.
10. Hom AC, Buterbaugh GG. Estrogen alters the acquisition of seizures kindled by repeated amygdala stimulation or pentylenetetrazol administration in ovariectomized female rats. Epilepsia 1986, 27:103-108.
11. Julien RM, Fowler GW, Danielson MG. The effects of antiepileptic drugs on estrogen--induced electrographic spike-wave discharge. J Pharmacol Exp Ther 1975, 193:647-656.
12. Landgren S, Backstrom T, Kalistratov G. The effect of progesterone on the spontaneous interictal spike evoked by the application of penicillin to the cats cerebral cortex. J Neurol Sci 1978, 36:119-133.
13. Lange SC, Julien RM. Re-evoluation of estrogen: induced cortical and thalamic paroxysmal EEG activity in the cat. Electroenceph Clin Neurophisiol 1978, 44:94-103.
14. Lennox WG, Lennox MA. Epilepsy and Related Disorders. Boston: Little Brown, 1960, Vol 2, p 645-650.
15. Logothetis J, Harner R. Electrocortical activation by estrogens. Arch Neurol 1960, 3:290-297.
16. Logothetis J, Harner R, Morrel F, Torres F. The role of estrogens in catamenial exacerbation of epilepsy. Neurology 1950, 9:352-360.
17. Marcus EM, Watson CW, Goldman PL. Effects of steroids on cerebral electrical activity: epileptogenic effects of conjugated estrogens and related compounds in the cat and rabbit. Arch Neurol 1966, 15:521-532.
18. Marcus MM, Watson CW, Simin SA. Behavioral correlates of acute bilateral symmetrical epileptogenic foci in monkey cerebral cortex. Brain Res 1968, 9:370-373.
19. Mirsky AF, Bloch S, Tecce JJ, Lessell S, Marcus E. Visual evoked potentials during experimentally induced spike-wave activity in monkeys. Electroenceph Clin Neurophisiol 1973, 35:25-37.
20. Newmark ME, Penry JK. Catamenial epilepsy : a review: Epilepsia 1980, 21:281-300.
21. Nicoletti F, Meek JL. Estradiol benzoate decreases nigral GABAergic activity in male rats. Brais Res 1985, 32:173-179.
22. Nicoletti F, Speciale C, Scortino MA, Summa G, Caruso GL, Patti F, Canonico PL. Comparative effects of estradiol benzoate, the antiestrogen clomiphene citrate, and the progestin in medroxyprogesterone acetate on kainic acid-induced seizures in male and female rats. Epilepsia 1985, 26:252-257.
23. Roscizewska D, Buntner B, Guz I, Zawisza L. Ovarian hormones, anticonvulsants drugs, and seizures during the menstrual cycle in women with epilepsy. J Neurol Neurosurg Psychiat 1986, 49:47-51.
24. Sanches Longo LP, Gonzalez Saldaña LE. Hormones and their influence in epilepsy. Acta Neurol Lat Am 1966, 12:29-47.
25. Spiegel E, Wycis H. Anticonvulsant effects of steroids. J Lab Clin Med 1945, 36:947-953.
26. Stitt SL, Kinnard WJ. The effect of certain progestins and estrogens on the threshold of electrically induced seizure patterns. Neurology 1968, 18:213-216.
27. Turner WA. Epilepsy: a Study of the Idiophatic Diseasse. London: MacMillan, 1907. Reprint, New York: Raven Press, 1973.
28. Werboff J, Corcoran JB. Effects of sex hormone manipulation on audiogenic seizures. Am J Psysiol 1961, 201:830-832.
29. Werboff J, Hedlund L, Havlena J. Audiogenic seizures in adult male castrated rats treated with various hormones. Gen Comp Endocrinol 1963, 3:389-397.
30. Woolley DE, Timiras PS. The gonad-brains relationship: effects of female sex hormones on electroshock convulsion in the rat. Endocrinology 1962, 70:196-209.

INÍCIO DE CRISES EPILÉPTICAS NA MENARCA

Epileptic seizures starting in menarche

Datas de Publicação

Publicação nesta coleção
22 Fev 2011
Data do Fascículo
Dez 1991

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Backstrom T, Zetterlund B, Blom S, Romano M. Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with parcial epilepsy. Acta Neurol Scand 1984, 69:240-248.

[2] 2. Bander B, Kaufman C, Dykens JW, Schleifer M, Shapiro LN. Seizures and the menstrual cycle. Am J Psychiat 1957, 113:704-708.

[3] 3. Costa PJ, Bonnycastle DD. The effect of DCA compound E, testosterone, progesterone and ACTH in modifying «agene-induced» convulsions in dogs. Arch Int Pharmacodyn 1952, 91:330-338.

[4] 4. Craig CR. Anticonvulsant activity of steroids: separability of anticonvulsant from hormonal effects. J Pharmacol Exp Ther 1966, 153:337-343.

[5] 5. Gowers WR. Epilepsy and Other Chronic Convulsive Disease: Their Causes, Symptons and Treatment. New York: William Wood, 1885.

[6] 6. Hardy RW. Unit activity in premarin-induced cortical epileptogenic foci. Epilepsia 1970, 11:179-186.

[7] 7. Heim LM. Effect of estradiol on brain maturation: dose and time response relationships. Endocrinology 1966, 78:1130-1134.

[8] 8. Helmchen H, Kunkel H, Selbach H. Periodische Einflusse auf die individuale Haufigkeit cerebraler Anfalle. Arch Psychiat Nervenkr 1964, 206:293-308.

[9] 9. Holmes GL, Weber DA. The effect of progesterone on kindling: a developmental study. Dev Brain Res 1984, 16:45-53.

[10] 10. Hom AC, Buterbaugh GG. Estrogen alters the acquisition of seizures kindled by repeated amygdala stimulation or pentylenetetrazol administration in ovariectomized female rats. Epilepsia 1986, 27:103-108.

[11] 11. Julien RM, Fowler GW, Danielson MG. The effects of antiepileptic drugs on estrogen--induced electrographic spike-wave discharge. J Pharmacol Exp Ther 1975, 193:647-656.

[12] 12. Landgren S, Backstrom T, Kalistratov G. The effect of progesterone on the spontaneous interictal spike evoked by the application of penicillin to the cats cerebral cortex. J Neurol Sci 1978, 36:119-133.

[13] 13. Lange SC, Julien RM. Re-evoluation of estrogen: induced cortical and thalamic paroxysmal EEG activity in the cat. Electroenceph Clin Neurophisiol 1978, 44:94-103.

[14] 14. Lennox WG, Lennox MA. Epilepsy and Related Disorders. Boston: Little Brown, 1960, Vol 2, p 645-650.

[15] 15. Logothetis J, Harner R. Electrocortical activation by estrogens. Arch Neurol 1960, 3:290-297.

[16] 16. Logothetis J, Harner R, Morrel F, Torres F. The role of estrogens in catamenial exacerbation of epilepsy. Neurology 1950, 9:352-360.

[17] 17. Marcus EM, Watson CW, Goldman PL. Effects of steroids on cerebral electrical activity: epileptogenic effects of conjugated estrogens and related compounds in the cat and rabbit. Arch Neurol 1966, 15:521-532.

[18] 18. Marcus MM, Watson CW, Simin SA. Behavioral correlates of acute bilateral symmetrical epileptogenic foci in monkey cerebral cortex. Brain Res 1968, 9:370-373.

[19] 19. Mirsky AF, Bloch S, Tecce JJ, Lessell S, Marcus E. Visual evoked potentials during experimentally induced spike-wave activity in monkeys. Electroenceph Clin Neurophisiol 1973, 35:25-37.

[20] 20. Newmark ME, Penry JK. Catamenial epilepsy : a review: Epilepsia 1980, 21:281-300.

[21] 21. Nicoletti F, Meek JL. Estradiol benzoate decreases nigral GABAergic activity in male rats. Brais Res 1985, 32:173-179.

[22] 22. Nicoletti F, Speciale C, Scortino MA, Summa G, Caruso GL, Patti F, Canonico PL. Comparative effects of estradiol benzoate, the antiestrogen clomiphene citrate, and the progestin in medroxyprogesterone acetate on kainic acid-induced seizures in male and female rats. Epilepsia 1985, 26:252-257.

[23] 23. Roscizewska D, Buntner B, Guz I, Zawisza L. Ovarian hormones, anticonvulsants drugs, and seizures during the menstrual cycle in women with epilepsy. J Neurol Neurosurg Psychiat 1986, 49:47-51.

[24] 24. Sanches Longo LP, Gonzalez Saldaña LE. Hormones and their influence in epilepsy. Acta Neurol Lat Am 1966, 12:29-47.

[25] 25. Spiegel E, Wycis H. Anticonvulsant effects of steroids. J Lab Clin Med 1945, 36:947-953.

[26] 26. Stitt SL, Kinnard WJ. The effect of certain progestins and estrogens on the threshold of electrically induced seizure patterns. Neurology 1968, 18:213-216.

[27] 27. Turner WA. Epilepsy: a Study of the Idiophatic Diseasse. London: MacMillan, 1907. Reprint, New York: Raven Press, 1973.

[28] 28. Werboff J, Corcoran JB. Effects of sex hormone manipulation on audiogenic seizures. Am J Psysiol 1961, 201:830-832.

[29] 29. Werboff J, Hedlund L, Havlena J. Audiogenic seizures in adult male castrated rats treated with various hormones. Gen Comp Endocrinol 1963, 3:389-397.

[30] 30. Woolley DE, Timiras PS. The gonad-brains relationship: effects of female sex hormones on electroshock convulsion in the rat. Endocrinology 1962, 70:196-209.