HTLV-I associated myelopathy in salvador (northeastern Brazil)

Meireles, A.; Moreira Jr., E. D.; Moreno-Carvalho, O. A.; Badaro, R.; Melo, A.

doi:10.1590/S0004-282X1992000200010

Abstracts

Recent studies of tropical spastic paraparesis have confirmed the existence of human T-cell leukemia virus type-1 (HTLVI) in several tropical areas of the world. In order to determine the role of HTLVI as an etiologic agent of myelopathies in Salvador, we conducted a clinical and serological study in 43 patients with non-traumatic and non-tumoral myelopathies. We found 9 patients with HTLVI associated myelopathy (HAM) which points to a new endemic area of HAM.

HTLVI; myelopathy; tropical spastic paraparesis

Recentes estudos têm mostrado ia presença de mielopatia associada a infecção por HTLV-I em muitas áreas tropicais do mundo. Com o objetivo de determinar o papel do HTLV-I como agente etiológico de mielopatias em Salvador, realizamos estudo clínico e sorológico em 43 pacientes com mielopatia de etiologia não traumática e não tumoral. Encontramos 9 pacientes com mielopatia associada a HTLV-I (HAM) o que sugere nova área endêmica de HAM.

HTLV-I; mielopatia; paraparesia espástica tropical

A. Meireles^I; E. D. Moreira Jr.^II; O. A. Moreno-Carvalho^III; R. Badaro^IV; A. Melo^V

^IHSA. Santo Antonio Hospital (HSA) and Federal University of Bahia (UFBA), Salvador

^IIUFBA. Santo Antonio Hospital (HSA) and Federal University of Bahia (UFBA), Salvador

^IVSanto Amaro Hospital, Salvador. Santo Antonio Hospital (HSA) and Federal University of Bahia (UFBA), Salvador

^IVUFBA and Cornel University Medical College, New York. Santo Antonio Hospital (HSA) and Federal University of Bahia (UFBA), Salvador

^VHSA and UFBA. Santo Antonio Hospital (HSA) and Federal University of Bahia (UFBA), Salvador

SUMMARY

Recent studies of tropical spastic paraparesis have confirmed the existence of human T-cell leukemia virus type-1 (HTLVI) in several tropical areas of the world. In order to determine the role of HTLVI as an etiologic agent of myelopathies in Salvador, we conducted a clinical and serological study in 43 patients with non-traumatic and non-tumoral myelopathies. We found 9 patients with HTLVI associated myelopathy (HAM) which points to a new endemic area of HAM.

Key words: HTLVI, myelopathy, tropical spastic paraparesis.

RESUMO

Recentes estudos têm mostrado ia presença de mielopatia associada a infecção por HTLV-I em muitas áreas tropicais do mundo. Com o objetivo de determinar o papel do HTLV-I como agente etiológico de mielopatias em Salvador, realizamos estudo clínico e sorológico em 43 pacientes com mielopatia de etiologia não traumática e não tumoral. Encontramos 9 pacientes com mielopatia associada a HTLV-I (HAM) o que sugere nova área endêmica de HAM.

Palavras-chave: HTLV-I, mielopatia, paraparesia espástica tropical.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Dr. Ailton Melo Departamento de Ciências da Biorregulaçãoo, Instituto de Ciências da Saúde, UFBA - Av. Reitor Miguel Calmon s/n - 40120 Salvador BA - Brasil.

1. Castro LHM, Chaves CJ, Callegaro D, Nobrega JPS, Scaff M. HTLV-1 associated myelopathy in Brazil: a preliminary report. Arq. Neuropsiquiat 1989, 47:501-502.
2. Cortes E, Detels R, Aboulafia, D, Li XL, Moudgil T, Alan M, Bonecker C, Gonzaga A, Oyafuso L, Tondo M, Boite C, Hammaershlak N, Capitani C, Slamon PJ, Ho DD, HIV-1, HIV-2 and HTLV-1 infection in high-risk groups in Brazil. N Engl J Med 1989, 320: 953-958.
3. Costa CMC, Salgueiro MR, Carton H, Vale OC, Arruda AM. Tropical spastic paraparesis in northeastern Brazil. Arq Neuropsiquiat 1989, 47:134-138.
4. Lee H, Anderson E. Alain JP, Gonzaga, A. HTLV-1 infection in Brazil. Blood 1989, 73:1742.
5. Moreira ED Jr, Harrington W Jr, Ribeiro T, Brites C, Melo A, Swanson P, Lee H, Badaro R. HTLV-II and a new endemic area for HTLV-I in Brazil (in press).
6. Osame M, Igata A, Matsumoto, M. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986, 1:1031-1032.
7. Roman GC, Roman LN, Spencer PS, Schoenberg BS. Tropical spastic paraparesis: a neuroepidemiological study in Colombia. Ann Neurol 1985, 17:361-365.
8. Roman GC. The neuroepidemiology of tropical spastic paraparesis. Ann Neurol 1988, 23 (Suppl): 113-130.
9. Sheremata WA, Quencer R, Gatti E, Freitas E, Harper M, Koprowski H. Magnetic resonance imaging of tropical spastic paraplegia. Neurology 1987, 374 (Suppl 1) :322.
10. Spina-França A, Livramento JA, Machado LR, Gomes HR, Vianna LS, Castro LHM, No-brega JPS, Bacheschi LA. HTLV-1 antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil, Arq Neuropsiquiat 1990,48:441-447.

HTLV-I associated myelopathy in salvador (northeastern Brazil)

Mielopatia associada a HTLV-I em Salvador

Publication Dates

Publication in this collection
22 Feb 2011
Date of issue
June 1992

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Castro LHM, Chaves CJ, Callegaro D, Nobrega JPS, Scaff M. HTLV-1 associated myelopathy in Brazil: a preliminary report. Arq. Neuropsiquiat 1989, 47:501-502.

[2] 2. Cortes E, Detels R, Aboulafia, D, Li XL, Moudgil T, Alan M, Bonecker C, Gonzaga A, Oyafuso L, Tondo M, Boite C, Hammaershlak N, Capitani C, Slamon PJ, Ho DD, HIV-1, HIV-2 and HTLV-1 infection in high-risk groups in Brazil. N Engl J Med 1989, 320: 953-958.

[3] 3. Costa CMC, Salgueiro MR, Carton H, Vale OC, Arruda AM. Tropical spastic paraparesis in northeastern Brazil. Arq Neuropsiquiat 1989, 47:134-138.

[4] 4. Lee H, Anderson E. Alain JP, Gonzaga, A. HTLV-1 infection in Brazil. Blood 1989, 73:1742.

[5] 5. Moreira ED Jr, Harrington W Jr, Ribeiro T, Brites C, Melo A, Swanson P, Lee H, Badaro R. HTLV-II and a new endemic area for HTLV-I in Brazil (in press).

[6] 6. Osame M, Igata A, Matsumoto, M. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986, 1:1031-1032.

[7] 7. Roman GC, Roman LN, Spencer PS, Schoenberg BS. Tropical spastic paraparesis: a neuroepidemiological study in Colombia. Ann Neurol 1985, 17:361-365.

[8] 8. Roman GC. The neuroepidemiology of tropical spastic paraparesis. Ann Neurol 1988, 23 (Suppl): 113-130.

[9] 9. Sheremata WA, Quencer R, Gatti E, Freitas E, Harper M, Koprowski H. Magnetic resonance imaging of tropical spastic paraplegia. Neurology 1987, 374 (Suppl 1) :322.

[10] 10. Spina-França A, Livramento JA, Machado LR, Gomes HR, Vianna LS, Castro LHM, No-brega JPS, Bacheschi LA. HTLV-1 antibodies in serum and cerebrospinal fluid in tropical spastic paraparesis in Brazil, Arq Neuropsiquiat 1990,48:441-447.