Infecção citomegálica importância da citomegalia congênita na gênese da paralisia cerebral

Fontenelle, Lucia M. C.

doi:10.1590/S0004-282X1992000200011

Resumos

A citomegalia é considerada a mais frequente das infecções congênitas, sendo responsável por numerosos casos de deficiência mental e surdez. No Brasil, as publicações sobre este assunto prendem-se, mais especificamente, aos aspectos patológico e epidemiológico. Este estudo preocupa-se em mostrar a importância desta infecção na origem da paralisia cerebral, dando ênfase aos aspectos clínico e laboratorial.

citomegalovírus; infecção congênita; paralisia cerebral

In developed countries the congenital cytomegalovirus inclusion disease is considered to be nowadays an important problem of public health due to the great number of mental deficiency and deafness caused by it. In Brazil, publications related to the subject are rare, and more specifically they treat about pathologic and epidemiological aspects of the infection. In this study it is intended to show in our country the importance of the infection in the genesis of chronic encephalopathies. Emphasis is given to the clinical and serologic aspects.

cytomegalovirus; congenital infection; cerebral palsy

Lucia M. C. Fontenelle

Professora Assistente de Neurologia da Universidade Federal do Rio de Janeiro (UFRJ); Chefe do Setor de Neurologia Infantil do Instituto de Neurologia Deolindo Couto da UFRJ; Neuropediatra do Hospital Municipal Miguel Couto

RESUMO

A citomegalia é considerada a mais frequente das infecções congênitas, sendo responsável por numerosos casos de deficiência mental e surdez. No Brasil, as publicações sobre este assunto prendem-se, mais especificamente, aos aspectos patológico e epidemiológico. Este estudo preocupa-se em mostrar a importância desta infecção na origem da paralisia cerebral, dando ênfase aos aspectos clínico e laboratorial.

Palavras-chave: citomegalovírus, infecção congênita, paralisia cerebral.

SUMMARY

In developed countries the congenital cytomegalovirus inclusion disease is considered to be nowadays an important problem of public health due to the great number of mental deficiency and deafness caused by it. In Brazil, publications related to the subject are rare, and more specifically they treat about pathologic and epidemiological aspects of the infection. In this study it is intended to show in our country the importance of the infection in the genesis of chronic encephalopathies. Emphasis is given to the clinical and serologic aspects.

Key words: cytomegalovirus, congenital infection, cerebral palsy.

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Agradecimento Agradecemos à Professora Rita Maria Ribeiro Nogueira, do Departamento de Virologia da Fundação Oswaldo Cruz, a investigação sorológica e virológica.

Dra. Lucia M. C. Fontenelle Rua Sorocaba 464, Grupo 302 - 22271 Rio de Janeiro RJ - Brasil.

1. Bale JF Jr. Human cytomegalovirus infection and disorders of the nervous system. Arch Neurol 1984, 41:310-318.
2. Bray PF, Bale JF, Anderson RB, Kern ER. Progressive neurological disease associated with cytomegalovirus infection. Ann Neurol 1981, 9:499-502.
3. Elek SD, Stern H. Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero. Lancet 1974, 1:1-5.
4. Hanshaw JB. Cytomegalovirus complement-fixing antibody in microcephaly. N Engl J Med 1966, 275:476-479.
5. Hanshaw JB. Congenital cytomegalovirus infection: a fifteen year perspective. J Infect Dis 1971, 123:555-561.
6. Herrmann KL, Stewart JA. Serological diagnosis of perinatal infections. Am J Med Tech 1983, 49:149-154.
7. McCracken GH Jr, Shinefield HR, Cobb K, Rausen AR, Dische MR, Eichenwald HF. Congenital cytomegalic inclusion disease: a longitudinal study of 20 patients. Am J Dis Child 1969, 117:522-539.
8. Medearis DN Jr. Observations concerning human cytomegalovirus infection and disease. Bull Johns Hopk Hosp 1964, 114:181-211.
9. Nogueira RMR, Schatzmayr HG, Assis CER, Pinhão AT. Infecções pelo citomegalovírus e herpes simples tipo 2: amostragem em crianças de baixa idade no município do Rio de Janeiro. Clínica Pediátrica 1986, 10:22-28.
10. Pass RF, Stagno S, Myers GT, Alford CA. Outcome of syntomatic cytomegalovirus infection: results of long-term longitudinal follow-up. Pediatrics 1980, 66:758-762.
11. Saigal S, Lunik O, Larke RPB, Chernesky MA. The outcome in children whit congenital cytomegalovirus infection. Am J Dis Child 1982, 136:896-901.
12. Stagno S, Whitley RJ. Herpesvirus infections of pregnancy. Part I: Cytomegalovirus and Epstein Barr virus infections. N Engl J Med 1985, 313:1270-1274.
13. Strauss M, Davis GL. Viral disease of the labyrinth: I. Review of the literature and discussion of the role of cytomegalovirus in congenital deafness. Ann Otol 1973, 82:577-583.
14. Virnig NL, Balfour HH. Hemiatrophy and hemiparesis in a patient with congenital cytomegalovirus infection. Am J Dis Child 1975, 129:1359-1360.

Infecção citomegálica importância da citomegalia congênita na gênese da paralisia cerebral

The importance of congenital cytomegalovirus infection in the genesis of cerebral palsy.

Datas de Publicação

Publicação nesta coleção
22 Fev 2011
Data do Fascículo
Jun 1992

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Bale JF Jr. Human cytomegalovirus infection and disorders of the nervous system. Arch Neurol 1984, 41:310-318.

[2] 2. Bray PF, Bale JF, Anderson RB, Kern ER. Progressive neurological disease associated with cytomegalovirus infection. Ann Neurol 1981, 9:499-502.

[3] 3. Elek SD, Stern H. Development of a vaccine against mental retardation caused by cytomegalovirus infection in utero. Lancet 1974, 1:1-5.

[4] 4. Hanshaw JB. Cytomegalovirus complement-fixing antibody in microcephaly. N Engl J Med 1966, 275:476-479.

[5] 5. Hanshaw JB. Congenital cytomegalovirus infection: a fifteen year perspective. J Infect Dis 1971, 123:555-561.

[6] 6. Herrmann KL, Stewart JA. Serological diagnosis of perinatal infections. Am J Med Tech 1983, 49:149-154.

[7] 7. McCracken GH Jr, Shinefield HR, Cobb K, Rausen AR, Dische MR, Eichenwald HF. Congenital cytomegalic inclusion disease: a longitudinal study of 20 patients. Am J Dis Child 1969, 117:522-539.

[8] 8. Medearis DN Jr. Observations concerning human cytomegalovirus infection and disease. Bull Johns Hopk Hosp 1964, 114:181-211.

[9] 9. Nogueira RMR, Schatzmayr HG, Assis CER, Pinhão AT. Infecções pelo citomegalovírus e herpes simples tipo 2: amostragem em crianças de baixa idade no município do Rio de Janeiro. Clínica Pediátrica 1986, 10:22-28.

[10] 10. Pass RF, Stagno S, Myers GT, Alford CA. Outcome of syntomatic cytomegalovirus infection: results of long-term longitudinal follow-up. Pediatrics 1980, 66:758-762.

[11] 11. Saigal S, Lunik O, Larke RPB, Chernesky MA. The outcome in children whit congenital cytomegalovirus infection. Am J Dis Child 1982, 136:896-901.

[12] 12. Stagno S, Whitley RJ. Herpesvirus infections of pregnancy. Part I: Cytomegalovirus and Epstein Barr virus infections. N Engl J Med 1985, 313:1270-1274.

[13] 13. Strauss M, Davis GL. Viral disease of the labyrinth: I. Review of the literature and discussion of the role of cytomegalovirus in congenital deafness. Ann Otol 1973, 82:577-583.

[14] 14. Virnig NL, Balfour HH. Hemiatrophy and hemiparesis in a patient with congenital cytomegalovirus infection. Am J Dis Child 1975, 129:1359-1360.