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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.50 no.4 São Paulo Dec. 1992 

Neurotoxoplasmosis and aids cerebrospinal, fluid analysis in 96 patients


Neurotoxoplasmose e AIDS: estudo do líquido cefalorraqueano em 96 pacientes



L. R. MachadoI; J. A. LivramentoI; A. Spina -FrançaII

IAssistant Professor. CIN (Neurology Investigation Center, Departament of Neurology, Faculty of Medicine, São Paulo University) / LSF (Neurodiagnostic Laboratory)
IIEmeritus Professor. CIN (Neurology Investigation Center, Departament of Neurology, Faculty of Medicine, São Paulo University) / LSF (Neurodiagnostic Laboratory)




The behavior of CSF inflammatory pattern in patients with AIDS and/or toxoplasmosis of the CNS is studied in 176 patients, divided in three groups. In the first group, 96 patients with toxoplasmosis and AIDS are considered; in the second group, 50 patients with toxoplasmosis without AIDS; in the third group, 30 AIDS patients without toxoplasmosis nor any other opportunistic infection. It is possible to conclude that patients with toxoplasmosis associated to AIDS exhibit CSF inflammatory pattern similar to patients with neurotoxoplasmosis without AIDS, except in respect to gamma globulin rates for which a cumulative effect can be detected.

Key words: toxoplasmosis, central nervous system, cerebrospinal fluid, acquired immunodeficiency syndrome.


Foram estudados 176 pacientes com o objetivo de avaliar o comportamento da reação inflamatória no líquido cefalorraqueano (LCR) de pacientes com toxoplasmose do sistema nervoso central (SNC). Foram considerados três grupos de pacientes: o primeiro com toxoplasmose do SNC associada à síndrome de imunodeficiência adquirida (AIDS), com 96 pacientes; o segundo, com toxoplasmose, sem AIDS, com 50 pacientes; o terceiro, apenas com AIDS, sem qualquer infecção oportunista, com 30 pacientes. Verificou-se que o comportamento da reação inflamatória da toxoplasmose do SNC estudada pelo exame de LCR predomina sobre as características de base da AIDS, excepto no que diz respeito aos teores de globulinas gama; para estas, parece haver efeito cumulativo das duas patologias.

Palavras-chave: toxoplasmose, sistema nervoso central, líquido cefalorraqueano, síndrome de imunodeficiência adquirida.



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