Calcificações dos gânglios da base na infância

Guerreiro, Marilisa M.; Scotoni, Anna Elisa

doi:10.1590/S0004-282X1992000400016

Resumos

Apresentamos o estudo de quatro crianças com calcificações dos gânglios da base (CGB) ao exame tomográfico. Epilepsia foi a manifestação clínica presente em três casos, cuja investigação laboratorial revelou haver distúrbio do metabolismo do cálcio, pseudo-hipoparatireoidismo em um dos casos com certeza e, provavelmente, também nos outros dois pacientes. A primeira finalidade deste estudo é divulgar entidade potencialmente tratável, como causa de síndrome epiléptica na infância. O segundo objetivo é rever o assunto (CGB) em face da literatura, relacionando-a com a quarta, criança que apresentou encefalopatia com CGB.

calcificação de gânglios da base; infância; epilepsia; distúrbios!; do metabolismo do cálcio; doença de Hallervorden-Spatz

We report the study of four children with bilateral basal ganglia calcifications (BGC) visualized on CT scan. Epilepsy was the clinical manifestation of three patients whose laboratory investigation revealed abnormal calcium metabolism. The first aim of this paper is to call attention to a treatable entity that can cause epileptic syndromes in infancy and childhood. The second purpose is to review the literature comparing with our fourth child who presented encephalopathy with BGC.

basal ganglia calcification; childhood; epilepsy; calcium metabolism disturbances; Hallervorden-Spatz disease

Marilisa M. Guerreiro^I; Anna Elisa Scotoni^II

^IProfessor Assistente. Disciplina de Neurologia Infantil, Departamento de Neurologia, Faculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (UNICAMP)

^IIPós-Graduanda. Disciplina de Neurologia Infantil, Departamento de Neurologia, Faculdade de Ciências Médicas (FCM), Universidade Estadual de Campinas (UNICAMP)

RESUMO

Apresentamos o estudo de quatro crianças com calcificações dos gânglios da base (CGB) ao exame tomográfico. Epilepsia foi a manifestação clínica presente em três casos, cuja investigação laboratorial revelou haver distúrbio do metabolismo do cálcio, pseudo-hipoparatireoidismo em um dos casos com certeza e, provavelmente, também nos outros dois pacientes. A primeira finalidade deste estudo é divulgar entidade potencialmente tratável, como causa de síndrome epiléptica na infância. O segundo objetivo é rever o assunto (CGB) em face da literatura, relacionando-a com a quarta, criança que apresentou encefalopatia com CGB.

Palavras-chave: calcificação de gânglios da base, infância, epilepsia, distúrbios! do metabolismo do cálcio, doença de Hallervorden-Spatz.

SUMMARY

We report the study of four children with bilateral basal ganglia calcifications (BGC) visualized on CT scan. Epilepsy was the clinical manifestation of three patients whose laboratory investigation revealed abnormal calcium metabolism. The first aim of this paper is to call attention to a treatable entity that can cause epileptic syndromes in infancy and childhood. The second purpose is to review the literature comparing with our fourth child who presented encephalopathy with BGC.

Key words: basal ganglia calcification, childhood, epilepsy, calcium metabolism disturbances, Hallervorden-Spatz disease

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Dra. Marilisa Mantovani Guerreiro Departamento de Neurologia, FCM/UNICAMP - Caixa Postal 6111 - 13081 Campinas SP - Brasil.

1. Aicardi J, Goutières F. A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis. Ann Neurol 1984, 15:49-54.
2. Belman AL, Lantos G, Horoupian D, Novick BE, Ultmann MH, Dickson DW, Rubinstein A. AIDS: calcification of the basal ganglia in infants and children. Neurology 1986, 36:1192-1199.
3. Ben Hamida M. Maladie de Fahr. Encyclopédie Médico-Chirurgicale (Paris) 17062 M10-7-1972. Paris: Ed. Techniques, 1972.
4. Billard C, Dulac O; Bouloche J, Echenne B, Lebon P, Motte J, Robain O, Santini J J. Encephalopathy with calcifications of the basal ganglia in children: a reappraisal of Fahr's syndrome with respect to 14 new cases. Neuropediatrics 1989, 20:12-19.
5. Boiler F, Boiler M, Gilbert J. Familial idiopathic cerebral calcifications. J Neurol Neurosurg Psychiatry 1977, 40:280-285.
6. Braga FM, Zukerman E, Ferraz FAP, Vittuzzo R. Calcificações intensas e simétricas dos gânglios da base e cerebelo visualizadas na tomografia computadorizada. Arq Bras Neu-rocirurg 1985, 4:115-122.
7. Brannan TS, Burger AA, Chaudhary MY. Bilateral basal ganglia calcifications visualised on CT scan. J Neurol Neurosurg Psychi/atry 1980, 43:403-406.
8. Delgado-Rodrigues RN. Neurocisticercose associada a hipoparatireoidismo e doença de Fahr (?): registro de um caso. Arq Neuro-Psiquiat (São Paulo) 1984, 42:388-391.
9. Diament AJ, Machado LR, Cypel S, Ramos JL#A. Síndrome de calcificações dos gânglios da base, leucodistrofiia e pleocitose linfomonocitária crônica do líquido cefalorraqueano. Arq Neuro-Psiquiat (Sao Paulo) 1986, 44:185-190.
10. Illum F, Dupont E. Prevalence of CT-detected calcification in the basal ganglia in idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neuroradiology 1985, 27:32-37.
11. Kobayashi S, Yamadori I, Miki H, Omori M. Idiopathic nonarteriosclerotic cerebral calcification (Fahr's disease):an electron microscopic study. Neuropathol (Berlin) 1987, 73:62-66.
12. Koller WC, Cochran JW, Klawans L. Calcification of the basal ganglia: computerized tomography and clinical correlation. Neurology 1979, 29:328-333.
13. Larsen TA, Dunn HG, Jan JE, Calne DB. Dystonia and calcification of the basal ganglia. Neurology 1985, 35:533-537.
14. Lowenthal A, Bruyn GW. Calcification of the striopallidodentate system. In Vinken PJ, Bruyn GW (eds) : Handbook of Clinical Neurology : Diseases of the Basal Ganglia. Amsterdam: North-Holland, 1968, Vol 6, p 703-725.
15. Margolin D, Hammersttad J, Orwoll E, McClung M, Calhoun D. Intracranial calcification in hyperparathyroidism associated with gait apraxia and parkinsonism. Neurology 1980, 30:1005-1007.
16. Menta L, Trounce JO, Moore JR, Young ID. Familial calcification of the basal ganglia with cerebrospinal fluid pleocytosis. J Med Genetics 1986, 23:157-160.
17. Morgante L, Vita G, Meduri M, Di Rosa AE, Galatioto S, Coraci MA, Di Perri R. Fahr's syndrome: local inflammatory factors in the pathogenesis of calcification. J Neurol 1986, 233:19-22.
18. Muenter MD, Whisnant JP. Basal ganglia calcification, hypoparathyroidism, and extrapyramidal motor manifestations. Neurology 1968, 18:1075-1083.
19. Ogata A, Ishida S, Wada T. A survey of 37 cases with basal ganglia calcification (BGC) : CT-scan findings of BGC and its relationship to underlying diseases and epilepsy. Acta Neurol Scand 1987, 75:117-124.
20. Puvanendran K, Low CH, Boey HK, Tan KP. Basal ganglia calcification on computer tomographic scan: a clinical and radiological correlation. Acta Neurol Scand 1982, 66:309-315.
21. Queiroz AC, Malbouisson AMB. Calcificação de núcleos da base do cérebro: estudo anatomopatológico de 4 casos. Arq Neuro-Psiquiat (São Paulo) 1981, 39:321-326.
22. Smeyers-Verbeke J, Michotte Y, Pelsmaeckers J, Lowenthal A, Massart DL, Dekegel D, Karcher D. The chemical composition of idiopathic nonarteriosclerotic cerebral calcifications. Neurology 1975, 25:48-57.
23. Trautner RJ, Cummings JL, Read SL, Benson DF. Idiopathic basal ganglia calcification and organic mood disorder. Am J Psychiatry 1988, 145:350-353.

Calcificações dos gânglios da base na infância

Basal ganglia calcifications in children

Datas de Publicação

Publicação nesta coleção
22 Fev 2011
Data do Fascículo
Dez 1992

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Aicardi J, Goutières F. A progressive familial encephalopathy in infancy with calcifications of the basal ganglia and chronic cerebrospinal fluid lymphocytosis. Ann Neurol 1984, 15:49-54.

[2] 2. Belman AL, Lantos G, Horoupian D, Novick BE, Ultmann MH, Dickson DW, Rubinstein A. AIDS: calcification of the basal ganglia in infants and children. Neurology 1986, 36:1192-1199.

[3] 3. Ben Hamida M. Maladie de Fahr. Encyclopédie Médico-Chirurgicale (Paris) 17062 M10-7-1972. Paris: Ed. Techniques, 1972.

[4] 4. Billard C, Dulac O; Bouloche J, Echenne B, Lebon P, Motte J, Robain O, Santini J J. Encephalopathy with calcifications of the basal ganglia in children: a reappraisal of Fahr's syndrome with respect to 14 new cases. Neuropediatrics 1989, 20:12-19.

[5] 5. Boiler F, Boiler M, Gilbert J. Familial idiopathic cerebral calcifications. J Neurol Neurosurg Psychiatry 1977, 40:280-285.

[6] 6. Braga FM, Zukerman E, Ferraz FAP, Vittuzzo R. Calcificações intensas e simétricas dos gânglios da base e cerebelo visualizadas na tomografia computadorizada. Arq Bras Neu-rocirurg 1985, 4:115-122.

[7] 7. Brannan TS, Burger AA, Chaudhary MY. Bilateral basal ganglia calcifications visualised on CT scan. J Neurol Neurosurg Psychi/atry 1980, 43:403-406.

[8] 8. Delgado-Rodrigues RN. Neurocisticercose associada a hipoparatireoidismo e doença de Fahr (?): registro de um caso. Arq Neuro-Psiquiat (São Paulo) 1984, 42:388-391.

[9] 9. Diament AJ, Machado LR, Cypel S, Ramos JL#A. Síndrome de calcificações dos gânglios da base, leucodistrofiia e pleocitose linfomonocitária crônica do líquido cefalorraqueano. Arq Neuro-Psiquiat (Sao Paulo) 1986, 44:185-190.

[10] 10. Illum F, Dupont E. Prevalence of CT-detected calcification in the basal ganglia in idiopathic hypoparathyroidism and pseudohypoparathyroidism. Neuroradiology 1985, 27:32-37.

[11] 11. Kobayashi S, Yamadori I, Miki H, Omori M. Idiopathic nonarteriosclerotic cerebral calcification (Fahr's disease):an electron microscopic study. Neuropathol (Berlin) 1987, 73:62-66.

[12] 12. Koller WC, Cochran JW, Klawans L. Calcification of the basal ganglia: computerized tomography and clinical correlation. Neurology 1979, 29:328-333.

[13] 13. Larsen TA, Dunn HG, Jan JE, Calne DB. Dystonia and calcification of the basal ganglia. Neurology 1985, 35:533-537.

[14] 14. Lowenthal A, Bruyn GW. Calcification of the striopallidodentate system. In Vinken PJ, Bruyn GW (eds) : Handbook of Clinical Neurology : Diseases of the Basal Ganglia. Amsterdam: North-Holland, 1968, Vol 6, p 703-725.

[15] 15. Margolin D, Hammersttad J, Orwoll E, McClung M, Calhoun D. Intracranial calcification in hyperparathyroidism associated with gait apraxia and parkinsonism. Neurology 1980, 30:1005-1007.

[16] 16. Menta L, Trounce JO, Moore JR, Young ID. Familial calcification of the basal ganglia with cerebrospinal fluid pleocytosis. J Med Genetics 1986, 23:157-160.

[17] 17. Morgante L, Vita G, Meduri M, Di Rosa AE, Galatioto S, Coraci MA, Di Perri R. Fahr's syndrome: local inflammatory factors in the pathogenesis of calcification. J Neurol 1986, 233:19-22.

[18] 18. Muenter MD, Whisnant JP. Basal ganglia calcification, hypoparathyroidism, and extrapyramidal motor manifestations. Neurology 1968, 18:1075-1083.

[19] 19. Ogata A, Ishida S, Wada T. A survey of 37 cases with basal ganglia calcification (BGC) : CT-scan findings of BGC and its relationship to underlying diseases and epilepsy. Acta Neurol Scand 1987, 75:117-124.

[20] 20. Puvanendran K, Low CH, Boey HK, Tan KP. Basal ganglia calcification on computer tomographic scan: a clinical and radiological correlation. Acta Neurol Scand 1982, 66:309-315.

[21] 21. Queiroz AC, Malbouisson AMB. Calcificação de núcleos da base do cérebro: estudo anatomopatológico de 4 casos. Arq Neuro-Psiquiat (São Paulo) 1981, 39:321-326.

[22] 22. Smeyers-Verbeke J, Michotte Y, Pelsmaeckers J, Lowenthal A, Massart DL, Dekegel D, Karcher D. The chemical composition of idiopathic nonarteriosclerotic cerebral calcifications. Neurology 1975, 25:48-57.

[23] 23. Trautner RJ, Cummings JL, Read SL, Benson DF. Idiopathic basal ganglia calcification and organic mood disorder. Am J Psychiatry 1988, 145:350-353.