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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.51 no.1 São Paulo Mar. 1993

http://dx.doi.org/10.1590/S0004-282X1993000100005 

Tratamento profilático da enxaqueca: estudo prospectivo aberto com a flunarizina em 100 pacientes

 

Prophylactic treatment of migraine with flunarizine: a prospective open study in one hundred patients

 

 

Wilson Luiz SanvitoI; Berenice Cataldo G. OliveiraII

IProfessor Pleno. Trabalho da Disciplina de Clínica Neurológica da Faculdade de Ciências Médicas da Santa Casa de São Paulo
IIProfessora Instrutora. Trabalho da Disciplina de Clínica Neurológica da Faculdade de Ciências Médicas da Santa Casa de São Paulo

 

 


RESUMO

A eficácia da flunarizina, rua dose de 10 mg/dia, no tratamento profilático da enxaqueca foi avaliada em 100 pacientes durante 120 dias, em um estudo aberto. Noventa e três pacientes completaram o período da terapia referido e em 7 pacientes fomos obrigados a suspender a droga pela presença de importantes efeitos colaterais. Os principais efeitos adversos observados foram ganho de peso, sonolência diurna excessiva, cansaço e depressão do humor. Oitenta e um enxaquecosos se beneficiaram do tratamento, pela abolição das crises ou redução significativa de sua incidência e/ou intensidade. Os resultados permitem concluir que a flunarizina é droga eficaz no tratamento profilático da enxaqueca.

Palavras chave: enxaqueca, bloqueadores dos canais de cálcio, flunarizina.


SUMMARY

The prophylactic value of a daily dose of 10 mg flunarizine, a calcium antagonist, was analysed in 100 migraineurs during 4-month in an open study. Ninety-three patients completed the full 16-week course of therapy, and seven patients presented important adverse reactions requiring discontinuation of the drug. However, the seven patients who dropped out during flunarizine treatment were not considered in the analysis. Side-effects included weight gain, sleepiness, humor depression, paresthesias and dry mouth. Eighty-one patients experienced abolition or significant reduction in headache incidence and/ or severity. We conclude that flunarizine may be an effective drug in migraine prophylaxis.

Key words: migraine, calcium channel blockers, flunarizine.


 

 

Full text available only in PDF format.

Texto completo disponível apenas em PDF.

 

 

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Aceite: 04-julho-1992.

 

 

Dr. Wilson Luiz Sanvito — Disciplina de Neurologia, Faculdade de Ciências Médicas da Santa Casa — Rua Cesário Motta Jr. 112 — 01221-020 São Paulo SP — Brasil