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Esclerodermia, tireoidite e miastenia grave: estudo de um caso

Scleroderma, thyroiditis and myasthenia gravis: case report

Resumos

Uma paciente de 36 anos com miastenia grave desenvolveu após dois anos intolerância ao frio, o que conduziu ao diagnóstico de tireoidite de Hashimoto. Quatro anos mais tarde apresentou pele espessada nas mãos (esclerodermia limitada). O quadro clínico e os exames complementares encaminharam o diagnóstico para a forma CREST de esclerodermia sistêmica progressiva. Discute-se a dificuldade diagnóstica da esclerodermia, assim como suas síndromes de superposição. Doença de Hashimoto e miastenia grave constituem associação pouco frequente. A presença de esclerodermia e miastenia grave é rara. Não encontramos na literatura a coincidência destas três doenças.

miastenia grave; tireoidite; esclerodermia


A thirty-six years old woman with myasthenia gravis developed cold intolerance after two years, and Hashimoto's thryroiditis diagnosis was established. Four years later she exhibited skin thickening (limited scleroderma). Laboratory and clinical findings suggested the CREST type of systemic sclerosis. Difficulty in scleroderma diagnosis is discussed, as overlap of syndromes. Hashimoto's thyroiditis and myasthenia gravis are infrequently associated. Occurrence of scleroderma and myasthenia gravis in the same patient is rare. The coincidence of these three disorders was not found in literature.

myasthenia gravis; thyroiditis; scleroderma


Antonio L. dos Santos Werneck; Tamara Checcacci-Balod; Graça Tuma

Estudo realizado no Serviço de Neurologia do Hospital Central do Instituto de Assistência aos Servidores do Estado do Rio de Janeiro (HC/IASERJ)

RESUMO

Uma paciente de 36 anos com miastenia grave desenvolveu após dois anos intolerância ao frio, o que conduziu ao diagnóstico de tireoidite de Hashimoto. Quatro anos mais tarde apresentou pele espessada nas mãos (esclerodermia limitada). O quadro clínico e os exames complementares encaminharam o diagnóstico para a forma CREST de esclerodermia sistêmica progressiva. Discute-se a dificuldade diagnóstica da esclerodermia, assim como suas síndromes de superposição. Doença de Hashimoto e miastenia grave constituem associação pouco frequente. A presença de esclerodermia e miastenia grave é rara. Não encontramos na literatura a coincidência destas três doenças.

Palavras-chave: miastenia grave, tireoidite, esclerodermia.

SUMMARY

A thirty-six years old woman with myasthenia gravis developed cold intolerance after two years, and Hashimoto's thryroiditis diagnosis was established. Four years later she exhibited skin thickening (limited scleroderma). Laboratory and clinical findings suggested the CREST type of systemic sclerosis. Difficulty in scleroderma diagnosis is discussed, as overlap of syndromes. Hashimoto's thyroiditis and myasthenia gravis are infrequently associated. Occurrence of scleroderma and myasthenia gravis in the same patient is rare. The coincidence of these three disorders was not found in literature.

Key words: myasthenia gravis, thyroiditis, scleroderma.

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Agradecimento — Nossos agradecimentos à Dra. Eliane Francine Simon, do Serviço de Anatomia Patológica do HC/IASERJ.

Aceite: 17-março-1993.

Dr. Antonio Luiz dos Santos Werneck — Rua João de Barros 137 apto. 601 - 22441-100 Rio de Janeiro RJ - Brasil.

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  • Esclerodermia, tireoidite e miastenia grave: estudo de um caso

    Scleroderma, thyroiditis and myasthenia gravis: case report
  • Datas de Publicação

    • Publicação nesta coleção
      19 Jan 2011
    • Data do Fascículo
      Nov 1993
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