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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.52 no.2 São Paulo June 1994

http://dx.doi.org/10.1590/S0004-282X1994000200010 

Carbamazepine kinetics in cardiac patients before and during amiodarone

 

Cinética da carbamazepina em pacientes cardíacos antes e durante amiodarona

 

 

Silmara A.O. LeiteI; Paulo J.M. LeiteI; Gilberto A. RochaII; Philip A. RoutledgeIII; Paulo Rogério M. BittencourtI

IServiço de Neurologia, Hospital Nossa Senhora das Graças, Curitiba, Brasil
IIServiço de Cardiologia, Hospital Nossa Senhora das Graças, Curitiba, Brasil
IIIDepartamento de Farmacologia e Terapêutica, Universidade de País de Gales, Faculdade de Medicina, Heath Park, Cardiff, País de Gales

 

 


SUMMARY

Carbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy with amiodarone, 400 mg daily. The kinetic profile of carbamazepine, its free fraction, and serum amiodarone, were measured at the two occasions. There was no statistically significant change in carbamazepine kinetics or free fraction, before and after the introduction of amiodarone. The concentrations of amidarone after one month of therapy were low. It is sugested that the possible interaction in the hepatic metabolism was not demonstrated because amiodarone concentrations were not enough to inhibit carbamazepine metabolism.

Key words: amiodarone, carbamazepine, epilepsy, antiepileptic drags, arrythmia.


RESUMO

Carbamazepina e amiodarona podem frequentemente ser usadas em conjunto, especialmente em países em que as cardiomiopatias são comuns. Neste estudo doses de carbamazepina (400 mg) foram administradas a pacientes com doenças cardíacas antes e depois de um mês de terapia com amiodarona, 400 mg ao dia. O perfil cinético da carbamazepina, sua fração livre e o nível sérico da amiodarona, foram avaliados nas duas ocasiões. Não foram observadas diferenças estatisticamente significantes na cinética da carbamazepina ou mesmo em sua fração livre, antes e depois da introdução da amiodarona. A concentração da amiodarona após um mês de terapia foi baixa. Conclui-se que a possível interação no metabolismo hepático não foi demonstrada devido as baixas concentrações de amiodarona, que provavelmente tenham sido insuficientes para inibir o metabolismo da carbamazepina.

Palavras chave: amiodarona, carbamazepina, drogas antiepilépticas, arritmias.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

Acknowledgement - The authors would like to thank nursing staff at Hospital N.S. das Graças in Curitiba for their cooperation, and Ms Maristela G. Calderari and Ms Marli Osna for word processing. The study was supported by an internal grants of the Unidade de Neurologia Clínica S/C, Curitiba and of the Department of Pharmacology and Therapeutics, University of Wales College of Medicine.

 

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Aceite: 4-novembro-1993.

 

 

Dr. Paulo R.M. de Bittencourt - Unidade de Neurologia Clínica, Hospital Nossa Senhora das Graças - Rua Alcides Munhoz 433 - 80810-040 Curitiba PR - Brasil.