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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.52 no.3 São Paulo Sept. 1994

https://doi.org/10.1590/S0004-282X1994000300003 

Medidas quantitativas clínicas e eletrencefalográficas de epileptogênese na epilepsia do lobo temporal

 

Quantitative clinical and EEG measures of epileptogenesis in temporal lobe epilepsy

 

 

P.R.M. de BittencourtI; A.C. GabardoII; T. MarcourakisIII

IUnidades de Neurologia Clínica do Hospital Nossa Senhora das Graças, Curitiba
IITomografia Computadorizada do Hospital Nossa Senhora das Graças, Curitiba
IIICentro de Investigações em Neurologia da Faculdade de Medicina da Universidade de São Paulo

 

 


RESUMO

Neste estudo controlado, prospectivo e parcialmente cego foram avaliados dois grupos de 10 portadores de epilepsia do lobo temporal, respectivamente de bom e mau prognóstico. Foram definidas medidas de epileptogênese baseadas nas freqüências de crises e na quantificação de atividade epileptogênica nas derivações eletrencefalográficas de lobo temporal. Os grupos de estudo foram semelhantes a no mínimo um dos grupos de controle em idade, sexo, nível educacional e social, regime terapêutico, idade de início e tempo de evolução da epilepsia. Houve uma diferença global do grupo de epilepsia do lobo temporal com mau prognóstico das outras populações, atingindo significação estatística em epileptogênese clínica, e uma tendência dos dados sugerindo maior epileptogênese eletrencefalográfica na mesma população. Os resultados indicam a utilidade experimental de algumas das medidas introduzidas, mas também seus problemas. Revisão da literatura pertinente é realizada.

Palavras-chave: epilepsia do lobo temporal, epileptogênese, EEG.


SUMMARY

In this controlled, prospective and partially blind study two groups of patients with temporal lobe epilepsy were evaluated, respectively with good and bad prognosis. Measurements of epileptogenesis were based on frequency of seizures, and on epiletogenic eletroencephalographic abnormalities obtained from scalp electrodes over the temporal lobes. The results were analised by non-parametric analysis of variance, comparison of groups and analysis of correlation. The results indicated the temporal lobe groups were similar to at least one of the control groups in age, sex, educational and social level, therapeutic regime, age at onset and length of history of epilepsy. The quantitative measurements showed a global difference between the group of temporal lobe with bad and good prognosis, reaching statistical significance in clinical epileptogenesis, and a trend towards greater epileptogenesis on the eletroencephalogram, in the same group of patients. The results indicate the experimental usefulness of some of the original measurements used in the study, but also their problems. A review of the literature is carried out.

Key words: temporal lobe epilepsy, epileptogenesis, EEG.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

Agradecimento - Os autores reconhecem o auxílio durante a execução deste estudo dos Drs. P.A. Kowacs, R.R. Seixas e A.F. Seixas, então médicos do Centro Diagnóstico de Curitiba.

 

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Aceite: 12-dezembro-1994.

 

 

Estudo apresentado em parte como Tese (PRMB) aprovada em Concurso para Professor Titular de Doenças do Sistema Nervoso na Universidade Federal do Paraná (UFPR) em 1991.
Dr. Paulo Rogério Mudrovitsch de Bittencourt - Unidade de Neurologia Clínica S/C Ltda - Rua Padre Anchieta 155 80410-030 Curitiba PR - Brasil.

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