SciELO - Scientific Electronic Library Online

 
vol.52 issue3The role of muscle biopsy in the diagnosis of neuromuscular diseasesPathways involved in thalamic ventrobasal stimulation for pain relief: evidence against the hypothesis VB stimulation -> rostroventral medulla excitation -> dorsal horn inhibition author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.52 no.3 São Paulo Sept. 1994

https://doi.org/10.1590/S0004-282X1994000300015 

História do estudo da miastenia grave na clínica neurológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

 

History of the study of myasthenia gravis at Neurology Clinics of Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo

 

 

 

José Lamartine de Assis

Clínica Neurológica (CN), Hospital das Clínicas (HC), Faculdade de Medicina da Universidade de São Paulo (FMUSP): Professor Associado, Departamento de Neurologia, FMUSP

 

 


RESUMO

É sintetizada a evolução histórica dos estudos sobre miastenia grave na Clínica Neurológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo no período 1950-1992. São relatados os principais resultados observados na terapêutica, na clínica e na fisiopatologia, sendo destacados os estudos imunológicos e os avanços em biologia molecular.

Palavras-chave: miastenia grave, timectomia, imunossupressão, plasmaférese, imunologia, biologia molecular.


SUMMARY

It is synthetized the evolution of the researches on myasthenia gravis at the Department of Neurology of the Hospital das Clínicas of the Faculty of Medicine, Medical School of the University of São Paulo (Brazil) between 1950 and 1992. The most important results observed about therapeutical, clinical and pathophysiological researches are reviewed. Immunologic studies and advances on molecular biology are emphasized.

Key words: myasthenia gravis, thymectomy, immunosuppression, plasmapheresis, immunology, molecular biology


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

REFERÊNCIAS

1. Assis JL. Tratamento dos casos graves de miastenia: ação do ACTH e cortisona. Considerações a propósito de três casos. Arq Neuropsiquiatr 1956, 14: 28-36.         [ Links ]

2. Assis JL. Tratamento das formas severas de miastenia pelo ACTH por via intravenosa. Arq Neuropsiquiatr 1960, 18: 359-382.         [ Links ]

3. Assis JL, Carvalho L. Radiologia contrastada do timo na miastenia grave. Arq Neuropsiquiatr 1964, 22: 33-43.         [ Links ]

4. Assis JL, Saraiva PAP. Repouso da junção neuromuscular no tratamento das crises miastênicas e colinérgicas. Arq Neuropsiquiatr 1968, 26: 93-104.         [ Links ]

5. Assis JL, Saraiva S. Myasthenia gravis: therapeutical immunological correlation. Rev Hosp Clin Fac Med S Paulo 1971, 26: 213-216.         [ Links ]

6. Assis JL, Curi N. Timectomia na miastenia grave: avaliação dos resultados em 78 pacientes. Arq Neuropsiquiatr 1978, 36: 16-26.         [ Links ]

7. Assis JL, Marchiori PE, Zambon AA, Filomeno LTE, Scaff M. Immunosuppression with corticosteroids and thymectomy in myasthenia gravis: an evaluation of immediate and short term results in 20 patients. Arq Neuropsiquiatr 1985, 43: 17-21.         [ Links ]

8. Assis JL. Miastenia grave: evolução das pesquisas na Clínica Neurológica do Hospital das Clínicas da Faculdade de Medicina da USP. Arq Neuropsiquiat 1986, 44: 406-414.         [ Links ]

9. Assis JL, Marchiori PE, Scaff M, Zambon AA. Tratamento da miastenia grave mediante imunossupressão medicamentosa não esteróide. Arq Neuropsiquiatr 1986, 44: 109-116.         [ Links ]

10. Assis JL, Marchiori PE, Zambon AA, Scaff M. Tratamento conservador e timectomia na miastenia grave: resultados observados em dois grupos de pacientes acompanhados a longo prazo. Arq Neuropsiquiat 1987, 45: 119-130.         [ Links ]

11. Assis JL. Miastenia grave. São Paulo: Sarvier, 1990.         [ Links ]

12. Assis JL. Miastenia grave: avaliação crítica dos tratamentos. Arq Neuropsiquiatr 1990, 48: 55-70.         [ Links ]

13. Assis JL, Marchiori PE, Zambon AA, Scaff M. Thymectomy for myasthenia gravis: evaluation of results in 282 patients. Rev Hosp Clin Fac Med S Paulo 1992, 47: 117-120.         [ Links ]

14. Assis JL, Marchiori PE, Zambon AA, Scaff M. Juvenile myasthenia gravis and thymectomy: report of ten cases. Rev Hosp Clin Fac Med S Paulo 1992, 47: 234-236.         [ Links ]

15. Assis JL, Marchiori PE., Zambon AA, Scaff M. Thymectomy in over 50 years-old patients with myasthenia gravis: long and short-term results in 21 patients. Rev Hosp Clin Fac Med S Paulo 1993, 48: 22-24.         [ Links ]

15a. Assis JL, Marchiori PE., Zambon AA, Scaff M. Atrophy of the tongue in myasthenia gravis: report of 8 patients. In Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 131.         [ Links ]

15b. Baeta AM, Haddad MS, Tinone G, Assis JL, Marchiori PE, Scaff M. Myasthenia gravis associated with a diffuse indifferenciated lymphoma, report of case. In: Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 134.         [ Links ]

16. Brentani MM, Marchiori PE, Martins VR. Glucocorticoid receptors of mononuclear leukocytes from myasthenia gravis patients. Acta Neurol Scand 1985, 72: 788-792.         [ Links ]

17. Eaton LM, Clagett OT. Present status of thymectomy in the treatment of myasthenia gravis. Am J Med 1955, 19: 703-717.         [ Links ]

18. Glaser GH, Merritt HH. Effects of corticotropin (ACTH) and cortisone on disorders of the nervous system. JAMA 1952, 148: 898-904.         [ Links ]

18a. Haddad MS, Baeta AM, Tinone G, Assis JL, Marchiori PE, Scaff M. Development of myasthenia gravis (MG) after splenectomy. In J Neuroimmunol 1991, Suppl 1 (Internat Congr of Neuroimmunol 3. Jerusalem 1991), p 196.         [ Links ]

18b. Haddad MS, Assis JL, Marchiori PE, Scaff M. Myasthenia gravis and uveitis. Report of two cases. In Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 133.         [ Links ]

19. Kane CA. The effect of certain endocrine glands on myasthenia gravis. Am J Med 1955, 19:729-733.         [ Links ]

20. Lazzari AA, Marchiori PE, Oliveira RM, Reis M, Scaff M, Assis JL, Cossermelli W. High prevalence of antibodies against collagen in patients with myasthenia gravis: preliminary note. Neurobiologia (Recife) 1984, 47: 63-64.         [ Links ]

21. Lusvarghi E, Brotto M. Testes eletrofisiológicos: eletromiografia no diagnóstico da miastenia grave. In: Assis JL. Miastenia Grave. São Paulo: Sarvier, 1990, p 53.         [ Links ]

22. Marchiori PE, Scaff M, Mello EP, Trindade VS, Assis JL. Plasmaférese sem imunossupressão concomitante em miastenia grave: registro de caso. Rev Hosp Clin Fac Med S Paulo 1981, 36: 278-281.         [ Links ]

23. Marchiori PE, Oliveira RM, Scaff M, Reis M, Cossermelli W, Assis JL. anti-acetylcholine receptor antibodies in patients with myasthenia gravis: preliminary note. Neurobiologia (Recife) 1984, 47: 61-62.         [ Links ]

24. Marchiori PE. Anticorpo anti-receptor de acetilcolina em miastenia grave. Tese. Fac Med Univ São Paulo. São Paulo, 1985.         [ Links ]

25. Marchiori PE, Oliveira RM, Trindade VS, Scaff M, Assis JL, Cossermelli W. Circulating immune complexes in myasthenia gravis. Rev Hosp Clin Fac Med S Paulo 1985, 40: 13-14.         [ Links ]

26. Marchiori PE. Identificação e significado de elementos imunológicos e morfológicos na miastenia grave: valor diagnóstico para o timoma. Tese. Fac Med Univ São Paulo. São Paulo, 1987.         [ Links ]

27. Marchiori PE, Scaff M, Assis JL. Failure of cyclosporin-A in myasthenia gravis. Arq Neuropsiquiatr 1989, 47: 91-93.         [ Links ]

28. Marchiori PE, Roela RA, Koike MA A, Frederico HH, Brentani MM. Phenotypic analyses of thymus lymphocytes from patients with myasthenia gravis. In: International Congress of Immunology 8. Budapest, 1992,  p 44.         [ Links ]

29. Marchiori PE, Roela RA, Koike MAA, Frederico HH, Haddad M, Brentani MM. Integrin receptors analyses of thymic lymphocytes from patients with myasthenia gravis. In: International Congress of Immunology 8. Budapest, 1992, p 45.         [ Links ]

30. Marchiori PE. Imunogenética. In: Assis JL. Miastenia grave. São Paulo: Sarvier, 1990, p 177.         [ Links ]

30a. Marchiori PE, Assis JL, Scaff M. Use of cytolytic drugs in myasthenia gravis. In: J Neuroimmunol 1991, Suppl 1 (International Congress of Neuroimmunol 3,. Jerusalem, 1991) p 197.         [ Links ]

30b. Marchiori PE, Zambón A A, Assis JL, Scaff M. Myasthenia gravis: clinical and histopathological correlations in thymectomized patients. In J Neuroimmunol 1991 Suppl 1 (Internat Congr of Neuroimmunol 3. Jerusalem, 1991) p 197.         [ Links ]

30c. Marchiori PE, Scaff M, Assis JL, Saraiva PAP. Evaluation of the larynx muscle dysfunction in myasthenia gravis: an aid for diagnosis of MG using the respiratory function analysis. In Can J Neurol Sci, 1993,20, Suppl 4. (World Congr Neurol 15, Vancouver 1993) p S99.         [ Links ]

30d. Marchiori PE, Scaff M, Assis JL, Brentani MM, Martino VR. Neuroendocrinological evaluation on myasthenia gravis. In: Can J Neurol Sci 1993, 20, Suppl 4 (World Congr Neurol 15, Vancouver 1993) p S135.         [ Links ] 30e. Marchiori PE, Scaff M, Assis JL, TumaMF. The clinical and electrophysiological correlation of the blocking effect of antiacetylcholine receptor antibody in a vivo neuromuscular preparation of rats. In Can J Neurol Sci 1993,  20, Suppl 4 (World Congr Neurol 15, Vancouver 1993) p S99.         [ Links ]

31. Maria DA, Marchiori PE, Gauditano G, Pozzi DHB, Assis JL. Antibody-dependent citotoxicity (ADCC) patients with myasthenia gravis. In: Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 127.         [ Links ]

32. Marshal AEH, White RG. Experimental thymic lesions resembling those of myasthenia gravis. Lancet 1961, 1: 1030-1031.         [ Links ]

33. Mendes N, Koperstych S, Saraiva S, Assis JL. Imunidade celular na miastenia grave. Rev Hosp Clin Fac Med S Paulo 1978, 33:272-276.         [ Links ]

34. Millikan CH, Eaton LM. Clinical evaluation of ACTH in myasthenia gravis. Neurology 1951,1:145-152.         [ Links ]

35. Nastuk WL, Strauss AJL, Osserman KE. Search of a neuromuscular blocking agent in the blood of patients with myasthenia gravis. Am J Med 1959, 26: 394-409.         [ Links ]

36. Nastuk WL, Plescia OJ, Osserman KE. Changes in serum complement activity in patients with myasthenia gravis. Proc Soc Exp Biol Med 1960, 105: 177-184.         [ Links ]

37. Oliveira RM, Marchiori PE, Reis M, Zambón A A, Cossermelli W, Scaff M, Assis JL. Antibodies against an extractable muscle antigen in patients with myasthenia gravis: preliminary note. Neurobiologia (Recife) 1984, 47: 65-66.         [ Links ]

38. Reis M, Quevedo MEZ, Brentani MM, Oliveira RM, Assis JL, Scaff M, Marchiori PE. Anti-laminin antibody in myasthenia gravis. In International Symposium of Immunology 7. Berlin, 1989.         [ Links ]

39. Reis M, Oliveira RM, Quevedo ME, Scaff M, Marchiori PE. Acetylcholine receptor antibody in myasthenia gravis: the scatchard plot evaluation. In: Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 132.         [ Links ]

40. Saraiva S, Assis Jl, Camargo EM, Marlet JM. Myasthenia gravis: aspects of the clinical immunological correlation. Rev Hosp Clin Fac Med S Paulo 1971, 26: 111-114.         [ Links ]

41. Saraiva PAP, Assis Jl, Marchiori PE. Evaluation of the respiratory function in myasthenia gravis: an innovative diagnostic tool. In: Journées Internacionales de Pathologie Neuromusculaire 11. Marseille, 1992.         [ Links ]

42. Saraiva PAP, Assis JL, Marchiori PE. Evaluation of the respiratory function in myasthenia gravis: an innovative diagnostic tool. Trabalho para publicação.         [ Links ]

43. Savoy CV. Miastenia grave. Tese. Fac Med Univ São Paulo. São Paulo, 1945.         [ Links ]

44. Schlesinger NS. Present status of therapy in myasthenia gravis. JAMA 1952, 148: 508-513.         [ Links ]

45. Simpson JA. Evaluation of thymectomy in myasthenia gravis. Brain 1958, 81: 112-144.         [ Links ]

46. Simpson JA. Myasthenia gravis: a new hypothesis. Scot Med J 1960, 5: 419-456.         [ Links ]

47. Strauss AJL, Seegal BC, HSU KC, Burkholder PM, Nastuk WL, Osserman KE. Immunofluorescence demonstration of a muscule-binding complement-fixing serum globulin fraction in myasthenia gravis. Proc Soc Exp Biol 1960, 105: 184-191.         [ Links ]

48. Stump XMGRG. Tomografia axial computadorizada do mediastino anterior. In Assis JL. Miastenia grave. São Paulo: Sarvier, 1990, p 47.         [ Links ]

49. Tinone G, Haddad MS, Baeta AM, Marchiori PE, Assis JL, Scaff M. Myasthenia gravis and psoriasis: a case report. In: J Neuroimmunol 1991, Suppl 1. (Internat Congr Neuroimmunol 3, Jerusalem, 1991) p 196.         [ Links ]

50. Turna MFF. Miastenia grave induzida em animais por gamaglobulina de pacientes miastênicos: estudo clínico e eletrofisiologia em preparação neuromuscular. Tese. Fac Med Univ São Paulo. São Paulo, 1990.         [ Links ] 50a. Tuma MFF, Marchiori PE, Iaria CT. Experimental autoimmune myasthenia gravis by immunoglobulin of myasthenic patients: clinical and mechanical evaluation in a vivo neuromuscular system. Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 128.         [ Links ]

51. Vampré E. Moléstia de Erb-Goldfram. Comunicação feita na Sociedade de Medicina e Cirurgia de São Paulo em 08/09/1915. In Livro de Atas 8, p 2.         [ Links ]

52. Viana VST, Bueno C, Oliveira RM, Marchiori PE, Cossermelli W, Scaff M, Assis JL. Enzyme-linked immunosorbent assay for detection of antibodies in myasthenia gravis. First IUIS/Conference on Clinical Immunology (July, 1986). In: International Congress of Immunology 6. Toronto, 1986.         [ Links ]

53. Viana VST, Bueno C, Oliveira RM, Marchiori PE, Cossermelli W, Scaff M, Assis JL. Enzyme-linked immunosorbent assay for detection of antibodies to extractable muscle antigens in myasthenia gravis. Acta Neurol Scand 1986, 75: 599-601.         [ Links ]

54. Weltman E, Marchiori PE, Assis JL, Zambón AA, Tinone G. Failure of the total body irradiation in polymyositis and myasthenia gravis: report of 4 cases. In Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 19.         [ Links ]

55. Wendel SN. Métodos que removem anticorpos e células imunoagressivas: tratamento das crises miastênica e colinérgica. In Assis JL. Miastenia grave. São Paulo: Sarvier, 1990, p 253.         [ Links ]

56. Zambón AA. Timectomia na miastenia grave: avaliação de 150 pacientes em estudo histopatológico do timo. Tese. Fac Med Univ São Paulo. São Paulo 1991.         [ Links ]

56a. Zambón AA, Marchiori PE, Assis JL, Schultz R, Scaff M. Evaluation of demographic factors in MG: clinical and histopathological changes of the prednisone previous administration. In Congreso Panamericano de Neurologia 8. Montevideo, 1991, p 128.         [ Links ]

 

 

Aceite: 27-janeiro-1994.

 

 

Dr. José Lamartine de Assis - Rua Votuporanga, 243 - 01256-000 São Paulo SP - Brasil.

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License