SciELO - Scientific Electronic Library Online

 
vol.52 issue3Pathways involved in thalamic ventrobasal stimulation for pain relief: evidence against the hypothesis VB stimulation -> rostroventral medulla excitation -> dorsal horn inhibitionStriatocapsular infarction in childhood: report of four cases author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.52 no.3 São Paulo Sept. 1994

https://doi.org/10.1590/S0004-282X1994000300017 

Tumor neuroectodérmico primitivo supratentorial: estudo de quatro casos

 

Primitive neuroectodermal tumor of the central nervous system: report of four cases

 

 

Thais S. CianciarulloI; Beatrice Maria J. NevesI; João N. StávaleII

IDepartamento de Anatomia Patológica, Escola Paulista de Medicina: Acadêmica de Medicina com Bolsa de Iniciação Científica do CNPq
IIDepartamento de Anatomia Patológica, Escola Paulista de Medicina: Professor Adjunto

 

 


RESUMO

As alterações clinicopatológicas e imuno-histoquímicas de quatro casos de tumores neuroectodérmicos primitivos do sistema nervoso central foram investigadas. Três pacientes morreram. Todos os casos mostraram células vimentina positivas com morfologia de células neoplásicas e um caso mostrou células neoplásicas com imunoexpressão para proteína glial fibrilar acídica, enolase neuro-específica e neurofilamento. O presente estudo indica que este grupo de tumores tem mau prognóstico e pode mostrar alterações imuno-histoquímicas que indicam diferenciação glial e/ou neuronal.

Palavras-chave: tumor neuroectodérmico primitivo, imuno-histoquímica, diferenciação.


SUMMARY

The clinicopathological and immunohistochemical features of four cases of primitive neuroectodermal tumors of the central nervous system were investigated. Three patients died. All cases showed vimentin-positive cells with the morphology of neoplastic cells and one case showed glial fibrillary acidic protein, neuron-specific enolase and neurofilament protein-positive cell. The present study indicates that this group of tumors have bad prognostics and may show immunocytochemical features indicating glial and/or neuronal differentiation.

Key words: primitive neuroectodermal tumor, immunohistochemistry, differentiation.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

REFERENCES

1. Armed Forces Institute of Pathology (AFIP). Neuropathology review. 29th Annual Course. Washington DC: February 4-8, 1991.         [ Links ]

2. Becker LE, Hinton D. Primitive neuroectodermal tumors of the central nervous system. Hum Pathol 1983, 14: 538-550.         [ Links ]

3. Becker LE, Hinton D. Primitive neuroepithelial tumors of the central nervous system. In Finegold M (ed). Pathology of neoplasia in children and adolescents. Philadelphia: Saunders, 1986, p 397-418.         [ Links ]

4. Bennett JP Jr, Rubinstein LJ. The biological behavior of primary cerebral neuroblastoma: a reappraisal of the clinical course in a series of 70 cases. Ann Neurol 1984, 16: 21-27.         [ Links ]

5. Cruz-Sanchez FF, Rossi ML, Hughes JT, Moss TH. Differentiation in embryonal neuroepithelial tumors of the central nervous system. Cancer 1991, 67: 965-976.         [ Links ]

6. Gould VE, Rorke LB, Jansson DS, Molenaar WM, Trojanowski JQ, Lee VMY, Packer RJ, Franke WW. Primitive neuroectodermal tumors of the central nervous system express neuroendocrine markers and may express all classes of intermediate filaments. Hum Pathol 1990, 21: 245-252.         [ Links ]

7. Hart MN, Earle KM. Primitive neuroectodermal tumors of the brain in children. Cancer 1973, 32: 890-897.         [ Links ]

8. Horten BC, Rubinstein LJ. Primary cerebral neuroblastoma: a clinicopathological study of 35 cases. Brain 1976, 99: 735-756.         [ Links ]

9. Kleihues P, Burger PC, Scheithauer BW. The New WHO classification of brain tumours. Brain Pathol 1993, 3: 255-268.         [ Links ]

10. Rorke LB. Presidential address: the cerebellar medulloblastoma and its relationship to primitive neuroectodermal tumors. J Neuropath Exp Neurol 1983, 42: 1-15.         [ Links ]

11. Rorke LB, Gilles FH, Davis RL, Becker LE. Revision of the World Health Organization classification of childhood brain tumors. Cancer 1985, 56(Suppl): 1869-1886.         [ Links ]

12. Rubinstein LJ. Presidential address: cytogenesis and differentiation of primitive central neuroepithelial tumors. J Neuropath Exp Neurol 1972, 31: 7-26.         [ Links ]

13. Rubinstein LJ. Embryonal central neuroepithelial tumors and their differentiating potential. J Neuurosurg 1985, 62:795-805.         [ Links ]

14. Russell DS, Rubinstein LJ. Pathology of tumours of the nervous system Ed.5, London: Edward Arnold, 1989.         [ Links ]

 

 

Aceite: 17-março-1994.

 

 

Dr. João Norberto Stávale - Departamento de Anatomia Patológica, Escola Paulista de Medicina - Rua Botucatu 740 - 04023-900 São Paulo SP - Brasil.

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License