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Tumor neuroectodérmico primitivo supratentorial: estudo de quatro casos

Primitive neuroectodermal tumor of the central nervous system: report of four cases

Resumos

As alterações clinicopatológicas e imuno-histoquímicas de quatro casos de tumores neuroectodérmicos primitivos do sistema nervoso central foram investigadas. Três pacientes morreram. Todos os casos mostraram células vimentina positivas com morfologia de células neoplásicas e um caso mostrou células neoplásicas com imunoexpressão para proteína glial fibrilar acídica, enolase neuro-específica e neurofilamento. O presente estudo indica que este grupo de tumores tem mau prognóstico e pode mostrar alterações imuno-histoquímicas que indicam diferenciação glial e/ou neuronal.

tumor neuroectodérmico primitivo; imuno-histoquímica; diferenciação


The clinicopathological and immunohistochemical features of four cases of primitive neuroectodermal tumors of the central nervous system were investigated. Three patients died. All cases showed vimentin-positive cells with the morphology of neoplastic cells and one case showed glial fibrillary acidic protein, neuron-specific enolase and neurofilament protein-positive cell. The present study indicates that this group of tumors have bad prognostics and may show immunocytochemical features indicating glial and/or neuronal differentiation.

primitive neuroectodermal tumor; immunohistochemistry; differentiation


Tumor neuroectodérmico primitivo supratentorial: estudo de quatro casos

Primitive neuroectodermal tumor of the central nervous system: report of four cases

Thais S. CianciarulloI; Beatrice Maria J. NevesI; João N. StávaleII

IDepartamento de Anatomia Patológica, Escola Paulista de Medicina: Acadêmica de Medicina com Bolsa de Iniciação Científica do CNPq

IIDepartamento de Anatomia Patológica, Escola Paulista de Medicina: Professor Adjunto

RESUMO

As alterações clinicopatológicas e imuno-histoquímicas de quatro casos de tumores neuroectodérmicos primitivos do sistema nervoso central foram investigadas. Três pacientes morreram. Todos os casos mostraram células vimentina positivas com morfologia de células neoplásicas e um caso mostrou células neoplásicas com imunoexpressão para proteína glial fibrilar acídica, enolase neuro-específica e neurofilamento. O presente estudo indica que este grupo de tumores tem mau prognóstico e pode mostrar alterações imuno-histoquímicas que indicam diferenciação glial e/ou neuronal.

Palavras-chave: tumor neuroectodérmico primitivo, imuno-histoquímica, diferenciação.

SUMMARY

The clinicopathological and immunohistochemical features of four cases of primitive neuroectodermal tumors of the central nervous system were investigated. Three patients died. All cases showed vimentin-positive cells with the morphology of neoplastic cells and one case showed glial fibrillary acidic protein, neuron-specific enolase and neurofilament protein-positive cell. The present study indicates that this group of tumors have bad prognostics and may show immunocytochemical features indicating glial and/or neuronal differentiation.

Key words: primitive neuroectodermal tumor, immunohistochemistry, differentiation.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite: 17-março-1994.

Dr. João Norberto Stávale - Departamento de Anatomia Patológica, Escola Paulista de Medicina - Rua Botucatu 740 - 04023-900 São Paulo SP - Brasil.

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Datas de Publicação

  • Publicação nesta coleção
    19 Jan 2011
  • Data do Fascículo
    Set 1994
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