Hemorragia intratumoral em esclerose tuberosa: relato de caso

Hamamoto, Osmi; Honorato, Donizete César; Brito, Hugo L. F.; Souza-Queiróz, Luciano

doi:10.1590/S0004-282X1994000300026

Resumos

Os autores relatam o caso de uma paciente de 19 anos de idade, com quadro característico de esclerose tuberosa, que evoluiu com hemorragia maciça em astrocitoma subependimário de células gigantes e óbito súbito. Aspectos da fisiopatologia do sangramento são discutidos.

esclerose tuberosa; astrocitoma de células gigantes; hemorragia intratumoral

The authors report the case of 19 year-old patient with features of tuberous sclerosis that developed a massive hemorrhage in a subependymal giant-cell astrocytoma causing sudden death. Aspects of the pathophysiological bleeding are discussed.

tuberous sclerosis; giat-cell astrocytoma; intratumoral hemorrhage

Hemorragia intratumoral em esclerose tuberosa: relato de caso

Intratumoral hemorrhage in tuberous sclerosis: case report

Osmi Hamamoto^I; Donizete César Honorato^I; Hugo L. F. Brito^II; Luciano Souza-Queiróz^II

^ITrabalho realizado na Faculdade de Ciências Médicas (FCM) da Universidade Estadual de Campinas (UNICAMP): Departamento de Neurologia; Disciplina de Neurocirurgia

^IITrabalho realizado na Faculdade de Ciências Médicas (FCM) da Universidade Estadual de Campinas (UNICAMP): Departamento de Anatomia Patológica

RESUMO

Os autores relatam o caso de uma paciente de 19 anos de idade, com quadro característico de esclerose tuberosa, que evoluiu com hemorragia maciça em astrocitoma subependimário de células gigantes e óbito súbito. Aspectos da fisiopatologia do sangramento são discutidos.

Palavras-chave: esclerose tuberosa, astrocitoma de células gigantes, hemorragia intratumoral

SUMMARY

The authors report the case of 19 year-old patient with features of tuberous sclerosis that developed a massive hemorrhage in a subependymal giant-cell astrocytoma causing sudden death. Aspects of the pathophysiological bleeding are discussed.

Key words: tuberous sclerosis, giat-cell astrocytoma, intratumoral hemorrhage.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite: 25-março-1994.

Dr. Osmi Hamamoto - Departamento de Neurologia, Hospital das Clínicas da UNICAMP - Caixa Postal 6111 -13081-970 Campinas SP - Brasil.

1. Chow WC, Klug GL, Lewis EA. Subependymal giant-cell astrocytoma in children. J Neurosurg 1988, 68: 880-883.
2. Cozen M, Oppel F. Tuberous sclerosis in neurosurgery: an analysis of 18 patients. Acta Neurochir (Wien) 1990, 106: 106 - 109.
3. Barbosa-Coutinho LM, Lima EL, Gadret RO, Ferreira NP. Hemorragia maciça intratumoral em esclerose tuberosa Arq Neuropsiquiatr 1991, 49: 465 - 470.
4. Eizenberg HM. Supratentorial astrocytoma. American Association of Neurological Surgeons (eds). In Pediatric neurosurgery: summary of the developing nervous system. New York: Grune & Stratton, 1982, p 429 - 432.
5. Fitz CC. Tuberous sclerosis. In Hoffman HJ, Epstein F (eds). Disorders of the developing system: diagnosis and treatment. Boston MA: Blackwell, 1986.
6. Fryer AE. Tuberous sclerosis (Editorial). J Soc of Med 1991, 84: 699 - 701.
7. Globus JH, Sapirstein M. Massive hemorrhage in brain tumor. JAMA 1942, 120: 348 - 352.
8. Hahn JS, Bejar R, Gladson CL. Neonatal subependymal giant-cell astrocytoma associated with tuberous sclerosis: MRI, CT and ultrasound correlation. Neurology 1991, 41: 124 - 128.
9. Manganiello LOJ. Massive spontaneous hemorrhage in gliomas (a report of seven verified cases). J Nerv MentDis 1949, 110: 277 -298.
10. Mc Coyd K, Barron KD, Cassidy RJ. Acoustic neurinoma presenting as subarachnoid hemorrhage. J Neurosurg 1974,41: 391 -393.
11. Morimoto K, Mogami H. Sequential CT study of subependymal giant-cell astrocytoma associated with tuberous sclerosis. J Neurosurg 1986, 65: 874 - 877.
12. Osborne JP. Diagnosis of tuberous sclerosis (Annotations). Arch Dis Child 1988, 63: 1423 - 1425.
13. Russel DS, Rubinstein LJ. Pathology of tumors of the nervous system, Ed.5 New York: Williams and Wilkins, 1989, p 115 - 120.
14. Shepherd CW, Gomes MR, Lie JT, Crowson CS. Causes of death in patients with tuberous sclerosis. Mayo Clin Procl991,66: 792-796.
15. Shepherd CW, Scheithauer BW, Gomes MR, Altermatt HJ, Katzmann J A. Subependymal giant-cell astrocytoma: a clinical, pathological and flow cytometric study. Neurosurgery 1991, 28: 864 - 868.
16. Waga S, Yamamoto Y, Kojima T, Sakakura M. Massive hemorrhage in tumor of tuberous sclerosis. Surg Neurol 1977, 8: 99- 101.

Datas de Publicação

Publicação nesta coleção
19 Jan 2011
Data do Fascículo
Set 1994

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Chow WC, Klug GL, Lewis EA. Subependymal giant-cell astrocytoma in children. J Neurosurg 1988, 68: 880-883.

[2] 2. Cozen M, Oppel F. Tuberous sclerosis in neurosurgery: an analysis of 18 patients. Acta Neurochir (Wien) 1990, 106: 106 - 109.

[3] 3. Barbosa-Coutinho LM, Lima EL, Gadret RO, Ferreira NP. Hemorragia maciça intratumoral em esclerose tuberosa Arq Neuropsiquiatr 1991, 49: 465 - 470.

[4] 4. Eizenberg HM. Supratentorial astrocytoma. American Association of Neurological Surgeons (eds). In Pediatric neurosurgery: summary of the developing nervous system. New York: Grune & Stratton, 1982, p 429 - 432.

[5] 5. Fitz CC. Tuberous sclerosis. In Hoffman HJ, Epstein F (eds). Disorders of the developing system: diagnosis and treatment. Boston MA: Blackwell, 1986.

[6] 6. Fryer AE. Tuberous sclerosis (Editorial). J Soc of Med 1991, 84: 699 - 701.

[7] 7. Globus JH, Sapirstein M. Massive hemorrhage in brain tumor. JAMA 1942, 120: 348 - 352.

[8] 8. Hahn JS, Bejar R, Gladson CL. Neonatal subependymal giant-cell astrocytoma associated with tuberous sclerosis: MRI, CT and ultrasound correlation. Neurology 1991, 41: 124 - 128.

[9] 9. Manganiello LOJ. Massive spontaneous hemorrhage in gliomas (a report of seven verified cases). J Nerv MentDis 1949, 110: 277 -298.

[10] 10. Mc Coyd K, Barron KD, Cassidy RJ. Acoustic neurinoma presenting as subarachnoid hemorrhage. J Neurosurg 1974,41: 391 -393.

[11] 11. Morimoto K, Mogami H. Sequential CT study of subependymal giant-cell astrocytoma associated with tuberous sclerosis. J Neurosurg 1986, 65: 874 - 877.

[12] 12. Osborne JP. Diagnosis of tuberous sclerosis (Annotations). Arch Dis Child 1988, 63: 1423 - 1425.

[13] 13. Russel DS, Rubinstein LJ. Pathology of tumors of the nervous system, Ed.5 New York: Williams and Wilkins, 1989, p 115 - 120.

[14] 14. Shepherd CW, Gomes MR, Lie JT, Crowson CS. Causes of death in patients with tuberous sclerosis. Mayo Clin Procl991,66: 792-796.

[15] 15. Shepherd CW, Scheithauer BW, Gomes MR, Altermatt HJ, Katzmann J A. Subependymal giant-cell astrocytoma: a clinical, pathological and flow cytometric study. Neurosurgery 1991, 28: 864 - 868.

[16] 16. Waga S, Yamamoto Y, Kojima T, Sakakura M. Massive hemorrhage in tumor of tuberous sclerosis. Surg Neurol 1977, 8: 99- 101.