Pattern reversal visual evoked potentials in migraine subjects without aura

Moreira Filho, Pedro F.; Dantas, Adalmir M.

doi:10.1590/S0004-282X1994000400005

Abstracts

Twenty seven patients with migraine without aura were investigated. The age was between 12 and 54 years; 5 were men and 22 women. The diagnosis of migraine was made according to the classification proposed by the International Headache Society. The method of visual evoked potential was performed with pattern reversal (VEP-PR), with monocular stimulation. The stimulation was performed with pattern reversal with 4x4 cm black and white and red and green squared screen placed 1 meter from the nasion at stimulus frequency 1/s; 128 individual trials were analysed. The VEP-PR with black/white and red/green study showed a significant increase of value of the P-100 latency in 10 migraine patients. In 8 cases the LP100 in VEP-PR black/white was normal but in VEP-PR red/green the LP100 showed increase. Specifically in 1 of our cases, LP100 were normal in VEP-PR black/white but in the red/green there were no reproductice waves. On basis of these observations we consider that the method of VEP-PR is an useful instrument for investigation of migraine patients without aura.

migraine; pattern reversal evoked potential

Foram submetidos a estudo por potencial evocado visual padrão reverso (PEV-PR), preto e branco e vermelho e verde, 27 pacientes com o diagnóstico de enxaqueca sem aura pelos critérios estabelecidos pela Sociedade Internacional de Cefaléia. O estímulo usado em nossos enfermos foi o estruturado produzido por aparelho de televisão de 20 polegadas. Utilizamos inicialmente o padrão reverso xadrez em preto e branco e a seguir o vermelho e verde. A frequência foi de 1 estímulo por segundo e o total de estímulos somados foi 128. Constatamos latências normais da onda P100 em 9 casos tanto no PEV-PR preto/branco quanto no vermelho/ verde. As latências da onda P100 estavam aumentadas em 10 casos tanto no PEV-PR preto/branco como no vermelho/verde. Em 8 casos nos quais as latências de onda P100 estavam normais no PEV-PR preto/branco, havia comprometimento na PEV-PR vermelho/verde . Em 1 dos nossos casos a latência da onda P100 estava normal no PEV-PR preto/branco; entretanto no vermelho/verde não se evidenciaram ondas P-100. Será necessário maior número de exames para que no futuro possamos obter dados que nos ajudem a melhor entender a fisiopatologia da enxaqueca.

enxaqueca; migrânea; potencial evocado visual padrão reverso

Pattern reversal visual evoked potentials in migraine subjects without aura

Potencial evocado visual por padrão reverso em pacientes com enxaqueca sem aura

Pedro F. Moreira Filho; Adalmir M. Dantas

Departament of Clinical Medicine (Neurology), Hospital Universitário Antônio Pedro, Universidade Federal Fluminense, Rio de Janeiro

SUMMARY

Twenty seven patients with migraine without aura were investigated. The age was between 12 and 54 years; 5 were men and 22 women. The diagnosis of migraine was made according to the classification proposed by the International Headache Society. The method of visual evoked potential was performed with pattern reversal (VEP-PR), with monocular stimulation. The stimulation was performed with pattern reversal with 4x4 cm black and white and red and green squared screen placed 1 meter from the nasion at stimulus frequency 1/s; 128 individual trials were analysed. The VEP-PR with black/white and red/green study showed a significant increase of value of the P-100 latency in 10 migraine patients. In 8 cases the LP100 in VEP-PR black/white was normal but in VEP-PR red/green the LP100 showed increase. Specifically in 1 of our cases, LP100 were normal in VEP-PR black/white but in the red/green there were no reproductice waves. On basis of these observations we consider that the method of VEP-PR is an useful instrument for investigation of migraine patients without aura.

Key words: migraine, pattern reversal evoked potential.

RESUMO

Foram submetidos a estudo por potencial evocado visual padrão reverso (PEV-PR), preto e branco e vermelho e verde, 27 pacientes com o diagnóstico de enxaqueca sem aura pelos critérios estabelecidos pela Sociedade Internacional de Cefaléia. O estímulo usado em nossos enfermos foi o estruturado produzido por aparelho de televisão de 20 polegadas. Utilizamos inicialmente o padrão reverso xadrez em preto e branco e a seguir o vermelho e verde. A frequência foi de 1 estímulo por segundo e o total de estímulos somados foi 128. Constatamos latências normais da onda P100 em 9 casos tanto no PEV-PR preto/branco quanto no vermelho/ verde. As latências da onda P100 estavam aumentadas em 10 casos tanto no PEV-PR preto/branco como no vermelho/verde. Em 8 casos nos quais as latências de onda P100 estavam normais no PEV-PR preto/branco, havia comprometimento na PEV-PR vermelho/verde . Em 1 dos nossos casos a latência da onda P100 estava normal no PEV-PR preto/branco; entretanto no vermelho/verde não se evidenciaram ondas P-100. Será necessário maior número de exames para que no futuro possamos obter dados que nos ajudem a melhor entender a fisiopatologia da enxaqueca.

Palavras-chave: enxaqueca, migrânea, potencial evocado visual padrão reverso.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite: 1-junho-1994.

Dr. Pedro Ferreira Moreira Filho - Av. N.Sra. de Copacabana 540/606 - 22.020-000 Rio de Janeiro RJ - Brasil.

1. Connolly JF, Gawel M, Clifford Rose F. Migraine patients exhibit abnormalities in the visual evoked potential. J Neurol Neurosurg Psychiatry 1982, 45: 464-467.
2. Dalla Volta G, Anzola GP. Are there objective critteria to follow up migranous patients ? A prospective study with termography and evoked potentials. Headache 1988, 28: 423-425.
3. Diener H-C, Scholz E, Dichgans J, Gerber W-D, Jack A, Bille A, Niederberger U. Central effects of drugs used in migraine prophylaxis evaluated by visual evoked potentials. Ann Neurol 1989, 25: 125-130.
4. Golla FL, Winter AL. Analysis of cerebral responses to flicker in patients complaining of episodic headache. Electroencephalogr Clin Neurophysiol 1959, 11: 539-549.
5. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988, 8: 1-96.
6. Jasper HH. Report of the committee on methods of clinical examination in electroencephalography. Electroencephalogr. Clin Neurophysiol 1958, 10: 370-375.
7. Lehtonen JB. Visual evoked cortical potentials in man: studies on recording and stimulation technique, and findings in migraine patients.Thesis. University of Turku, 1972.
8. Mariani E, Moschini V, Pastorino G, Rizzi F, Severgnini A, Tiengo M. Pattern-reversal visual evoked potentials and EEG correlations in common migraine patients. Headache 1988, 28: 269-271.
9. Mariani E, Moschini V, Pastorino G, Rizzi F, Severgnini A, Tiengo M. Pattern reversal visual evoked potentials (VEP-PR) in migraine subjects with visual aura. Headache 1990, 30: 435-438.
10. Marsters JB, Good PA, Mortimer MJ. A diagnostic test for migraine using the visual evoked potential. Headache 1988, 28: 526-530.
11. Mortimer MJ, Good PA, Marsters JB, Addy DP. Visual evoked resposes in children with migraine: a diagnostic test. Lancet 1990, 335: 75-77.
12. Peatfield R. Visual evoked responses in children with migraine. Lancet 1990, 335: 480.
13. Raudino F. Visual evoked potential in patients with migraine. Headache 1988, 28: 531-533.
14. Richey ET, Kooi KA, Waggoner RW. Visually evoked responses in migraine. Electroencephalogr Clin Neurophysiol 1966, 21: 23-27.
15. Van Dijck JG, Dorresteijn M, Haan J, Ferrari MD. Visual evoked responses in children with migraine. Lancet 1991, 337: 517-518.

Publication Dates

Publication in this collection
19 Jan 2011
Date of issue
Dec 1994

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Connolly JF, Gawel M, Clifford Rose F. Migraine patients exhibit abnormalities in the visual evoked potential. J Neurol Neurosurg Psychiatry 1982, 45: 464-467.

[2] 2. Dalla Volta G, Anzola GP. Are there objective critteria to follow up migranous patients ? A prospective study with termography and evoked potentials. Headache 1988, 28: 423-425.

[3] 3. Diener H-C, Scholz E, Dichgans J, Gerber W-D, Jack A, Bille A, Niederberger U. Central effects of drugs used in migraine prophylaxis evaluated by visual evoked potentials. Ann Neurol 1989, 25: 125-130.

[4] 4. Golla FL, Winter AL. Analysis of cerebral responses to flicker in patients complaining of episodic headache. Electroencephalogr Clin Neurophysiol 1959, 11: 539-549.

[5] 5. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988, 8: 1-96.

[6] 6. Jasper HH. Report of the committee on methods of clinical examination in electroencephalography. Electroencephalogr. Clin Neurophysiol 1958, 10: 370-375.

[7] 7. Lehtonen JB. Visual evoked cortical potentials in man: studies on recording and stimulation technique, and findings in migraine patients.Thesis. University of Turku, 1972.

[8] 8. Mariani E, Moschini V, Pastorino G, Rizzi F, Severgnini A, Tiengo M. Pattern-reversal visual evoked potentials and EEG correlations in common migraine patients. Headache 1988, 28: 269-271.

[9] 9. Mariani E, Moschini V, Pastorino G, Rizzi F, Severgnini A, Tiengo M. Pattern reversal visual evoked potentials (VEP-PR) in migraine subjects with visual aura. Headache 1990, 30: 435-438.

[10] 10. Marsters JB, Good PA, Mortimer MJ. A diagnostic test for migraine using the visual evoked potential. Headache 1988, 28: 526-530.

[11] 11. Mortimer MJ, Good PA, Marsters JB, Addy DP. Visual evoked resposes in children with migraine: a diagnostic test. Lancet 1990, 335: 75-77.

[12] 12. Peatfield R. Visual evoked responses in children with migraine. Lancet 1990, 335: 480.

[13] 13. Raudino F. Visual evoked potential in patients with migraine. Headache 1988, 28: 531-533.

[14] 14. Richey ET, Kooi KA, Waggoner RW. Visually evoked responses in migraine. Electroencephalogr Clin Neurophysiol 1966, 21: 23-27.

[15] 15. Van Dijck JG, Dorresteijn M, Haan J, Ferrari MD. Visual evoked responses in children with migraine. Lancet 1991, 337: 517-518.