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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.52 no.4 São Paulo Dec. 1994

https://doi.org/10.1590/S0004-282X1994000400021 

Síndrome cerebeloso por amiodarona

 

Cerebellar syndrome by amiodarone

 

 

Neuda S. Garretto; Roberto D. Rey; Guillermo Kohler; Silvia Cocorullo; David A. Monteverde; Blanca I. Ravera; Roberto E.P. Sica

Division Neurologia, Hospital Jose Maria Ramos Mejia, Buenos Aires. Argentina

 

 


RESUMEN

La amiodarona (AMD) es una droga antiarritmica cuyos efectos adversos pueden comprometer el sistema nervioso central y periferico. La aparición de un síndrome cerebeloso es infrecuente. Se presenta un paciente masculino de 56 anos de edad que desarolla un síndrome pancerebeloso de 4 meses de evolución, que revierte luego de la suspension de la AMD. El cuadro reaparece meses mas tarde luego de un periodo de automedicacion con la droga. Los mecanismos tóxicos por los cuales la AMD afecta al cerebelo permanecen inciertos. Esta droga de amplia difusión en nuestro medio, como otros antiarritmicos, posee efectos sobre el sistema nervioso que deben ser tenidos en cuenta a fin de poder detectarlos precozmente.

Palabras-llave: síndrome cerebeloso, amiodarona.


SUMMARY

Amidarone (AMD) is an antiarrhytmic drug with side effects on the nervous system. Cerebellum is seldom involved. We describe the case of a 56 years old male patient with a history of 4 month of cerebellar involvement characterized by gait unstadiness, ataxia, nistagmus and vertigo. He was on treatment with AMD because of ventricular arrythmia. The cerebellar syndrom progressively disappeared after drug whitdrawal and he was symptoms-free 4 months later. Similar symptoms appeared after another one month of automedication with the same drug. Structural lesions, metabolic, nutritional deficiencies or toxics were excluded. Mechanisms of cerebellar toxicity of AMD are yet unknown. The knowledge of the toxic effects of this drug, widely used in our country, would allow its early recognition.

Key words: cerebellar syndrome, amiodarone.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

REFERÊNCIAS

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Aceite: 11-junho-1994.

 

 

Dra. Nelida S. Garretto - Division Neurologia Hospital Ramos Mejia - Urquiza 609 - 1221 - Buenos Aires -Argentina.

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