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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.1 São Paulo Mar. 1995

http://dx.doi.org/10.1590/S0004-282X1995000100002 

Distúrbios cognitivos na doença de Parkinson. Correlações eletrencefalográficas

 

Mental impairment in Parkinson disease: clinical and electroencephalographic correlations

 

 

João Santos PereiraI; Maria Lúcia Vellutini PimentelII; Paulo Luciano H. GomesIII

IProfessor Adjunto da FCM-UERJ, Doutor em Neurologia pela Escola Paulista de Medicina
IIMédica Neurologista
IIIProfessor Auxiliar-Ensino da FCM-UERJ, responsável pelo setor de eletrencefalografia

 

 


RESUMO

62 pacientes com diagnóstico de doença de Parkinson idiopática e 30 pacientes controle foram avaliados quanto a distúrbios mnemônicos e psíquicos, utilizando-se os critérios do DSM III-R, o mini-mental e a escala de Hamilton para depressão. Todos foram submetidos a eletrencefalograma (EEG) com fotoestimulação intermitente. Dos pacientes parkinsonianos, 24,2% apresentavam depressão psíquica, 14,5% ansiedade, 12,9% distimia, 3,2% demência e 45,2% não apresentavam quaisquer alterações de acordo com os critérios dos DSM III-R. Nos EEG evidenciavam-se ondas teta bilaterais com predomínio fronto-temporal ou temporal, com maior comprometimento à esquerda, em 58,1% desses pacientes. Em apenas 16 (7%) dos pacientes controle tais achados foram observados, porém, em nenhum dos dois grupos ocorreram alterações no EEG pela fotoestimulação. As alterações do EEG foram estatisticamente significantes quando se compararam pacientes parkinsonianos com pacientes controle (p<0,001); o mesmo não ocorreu quando se compararam pacientes parkinsonianos que apresentavam distúrbio psíquico com aqueles que não o apresentavam.

Palavras-chave: doença de Parkinson, depressão, distúrbios cognitivos, alterações eletrencefalográficas.


SUMMARY - Sixty-two patients with idiopathic Parkinson disease and 30 patients of a control group were clinically evaluated in the light of cognitive and/or psychic impairments according to DSM III-R, mini-mental state examination and Hamilton rating scale for depression. These patients were also submitted to electroencephalogram registration (EEG) with photic stimulation. From the parkinsonian group, 45.2% did not have mental manifestations as classified in the DSM III-R. Other 24.2% had depression, 14.5% had anxiety, 12,9% had dysthymic disorder and 3.2% had dementia. Considering the EEG, 58.1% of the parkinsonian patients had theta waves bilaterally, with predominance in frontal temporal or temporal areas, though more frequent on the left hemisphere than on the right one. Only 16.7% of the patients from the control group had these same findings in the EEG but neither of the two groups had their EEG modified by photic stimulation. The EEG findings were statistically significant when both groups were compared. However, these findings were not significant comparing parkinsonian patients with psychic impairment with the ones who did not have such impairments.

Key words: Parkinson disease, depression, cognitive impairment, electroencephalographic findings.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

Agradecimento

Ao professor Adriano Caldeira de Araújo, Professor Adjunto do Instituto de Biologia da UERJ, por sua colaboração na análise estatística. 

 

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Aceite: 8-julho-1994.

 

 

Dr. João Santos Pereira - Serviço de Neurologia, Hospital Universitário Pedro Ernesto - Rua 28 de setembro 77/ 2° andar - 20551-030 Rio de Janeiro RJ - Brasil.