Esclerose múltipla: análise clínica e evolutiva de 214 casos

Tilbery, Charles Peter; Felipe, Eduardo; Baldauf, Cristine Mella; Peres, Mário Fernando P.

doi:10.1590/S0004-282X1995000200003

Resumos

Os autores apresentam uma série de 214 casos de esclerose múltipla provenientes de levantamento retrospectivo de prontuários na Disciplina de Neurologia da Faculdade de Ciências Médicas da Santa Casa de São Paulo e da clínica privada, no período de 1980 a 1993. Os dados encontrados foram analisados quanto a sexo, raça, média de idade de início dos sintomas, sintomas iniciais e sintomas evolutivos da doença. Os resultados foram analisados comparativamente aos encontrados em outras séries nacionais e estrangeiras.

esclerose múltipla; casuísticas nacionais; casuísticas estrangeiras

The authors report on a series of 214 cases of defined multiple sclerosis according to Poser et al.criteria. These cases were retrospectively selected by medical reports analysed from Santa Casa Medical School (São Paulo) and the private practive, from 1980 to 1993. The data were analysed as for sex, race, onset ageof symptoms, onset symptoms, and evolutive symptoms. The results were compared to those found in other Brazilian series and in foreign series. This comparative analysis allows to verify similarities and differences among the several series, and the authors emphasize the necessity of multicentric studies in Brazil to assert with more details the multiple sclerosis profile in our country.

multiple sclerosis; national (Brazilian) series; foreign series

Esclerose múltipla: análise clínica e evolutiva de 214 casos

Multiple sclerosis: clinical and evolutive study of 214 cases

Charles Peter Tilbery^I; Eduardo Felipe^II; Cristine Mella Baldauf^III; Mário Fernando P. Peres^IV

^IProfessor Adjunto

^IIInstrutor de Ensino

^IIIResidente de terceiro ano

^IVAcadêmico de medicina

RESUMO

Os autores apresentam uma série de 214 casos de esclerose múltipla provenientes de levantamento retrospectivo de prontuários na Disciplina de Neurologia da Faculdade de Ciências Médicas da Santa Casa de São Paulo e da clínica privada, no período de 1980 a 1993. Os dados encontrados foram analisados quanto a sexo, raça, média de idade de início dos sintomas, sintomas iniciais e sintomas evolutivos da doença. Os resultados foram analisados comparativamente aos encontrados em outras séries nacionais e estrangeiras.

Palavras-chave: esclerose múltipla, casuísticas nacionais, casuísticas estrangeiras.

SUMMARY

The authors report on a series of 214 cases of defined multiple sclerosis according to Poser et al.criteria. These cases were retrospectively selected by medical reports analysed from Santa Casa Medical School (São Paulo) and the private practive, from 1980 to 1993. The data were analysed as for sex, race, onset ageof symptoms, onset symptoms, and evolutive symptoms. The results were compared to those found in other Brazilian series and in foreign series. This comparative analysis allows to verify similarities and differences among the several series, and the authors emphasize the necessity of multicentric studies in Brazil to assert with more details the multiple sclerosis profile in our country.

Key-words: multiple sclerosis, national (Brazilian) series, foreign series.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite: 5-dezembro-1994.

Setor de Investigações em Neuroimunologia da Disciplina de Neurologia da Faculdade de Ciências Médicas da Santa Casa de São Paulo:

Dr. Charles Peter Tilbery - Rua Sampaio Vidal 855 - 01443-001 São Paulo SP - Brasil.

1. Allison RS. Survival in disseminated sclerosis: a clinical study of a series of cases first seen twenty years ago. Brain 1950, 73:103-115.
2. Alter M, Halpern L, Kurland L, Bornstein B, Leibowitz U, Silberstein J. Multiple sclerosis in Israel: prevalence among immigrants and native inhabitants. Arch Neurol 1962, 7:253-263.
3. Bauer HJ. Problems of symptomatic therapy of multiple sclerosis. Neurology 1978, 28:8-20.
4. Bernardi S, Buttinelli C, Grasso MG, Millefiorni E, Pace A, Prencipe M, Fieschi C. Evolution and severity markers in 233 multiple sclerosis patients. Riv Neurol 1987, 57:197-200.
5. Callegaro D. Contribuiçăo do estudo clínico evolutivo da esclerose múltipla: análise de 120 pacientes. Tese de Doutorado, Faculdade de Medicina da Universidade de Săo Paulo. Săo Paulo 1989.
6. Callegaro D, Lolio CA, Radvany J, Tilbery CP, Mendonça RA, Melo ACP. Prevalence of multiple sclerosis in the city of Săo Paulo, Brazil, in 1990. Neuroepidemiology 1992, 11:11-14.
7. Confavreux C, Aimard G, Devic M. Course and prognosis of multiple sclerosis: computerized data processing of 349 patients. Brain 1980, 103:281-300.
8. Dean G. Epidemiology of multiple sclerosis. Neuroepidemiology 1984, 3:58-73.
9. Detels R, Visscher BR, Malmgren RM, Coulson AM, Lucia MV, Dudley JP. Evidence for lower susceptibility to multiple sclerosis in Japanese-Americans. Am J Epidemiol 1977, 106:303-310.
10. Detels R, Clark VA, Valdiviezo NL, Visscher BR, Malmgren RM, Dudley JP. Factors associated with a rapid course of multiple sclerosis. Arch Neurol 1982, 39:337-341.
11. Granieri E, Tola R, Paolino E, Rosati G, Carreras M, Moneti VC. The frequency of multiple sclerosis in Italy: a descriptive study in Fevrana. Ann Neurol 1985, 1:80-84.
12. Kuroiwa Y. Nationwide survery of MS in Japan. Neurology 1975, 25:845-851.
13. Kurtzke JF, Beebe GW, Dagler B, Auth TL, Kurland LT, Defzger MD. Studies on the natural history of multiple sclerosis: clinical and laboratory findings at first diagnoses. Acta Neurol Scand 1972, 48:19-46.
14. Lana-Peixoto MA, Lana-Peixoto MI. Is multiple sclerosis in Brazil and Asia alike? Arq Neuropsiquiatr 1992, 50:419-425.
15. Lauer K, Firnhaber W, Reining R, Leuchtweis B. Epidemiological investigations into multiple sclerosis in southern Hesse: I. Methodological problems and basic epidemiologic characteristics. Acta Neurol Scand 1984, 70:257-265.
16. Leibowitz V, Antonovski H, Katz R, Alter M. Does pregnancy increase the risk of multiple sclerosis? J Neurol Neurosurg Psychiatry 1967, 30:354-357.
17. Leite ACCB, Andrade C, Novis S. Esclerose múltipla no Rio de Janeiro: apresentaçăo clínica em 51 casos. Arq Neuropsiquiatr 1990, 48 (Supl): 66 A.
18. Mackay RP, Hirano A. Forms of benign multiple sclerosis: report of two "clinical silent cases" discovery at autopsy. Arch Neurol 1967, 17:588-600.
19. Papaiz-Alvarenga RM, Santos CMM, Bernardini JSA, Camargo SMGG. Esclerose múltipla: perfil clínico e epidemiológico no Rio de Janeiro. Arq Neuropsiquiatr 1990, 48 (Supl): 63 A.
20. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Silberg DH, Tourtellote WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983, 227-231.
21. Tan CT. Multiple sclerosis in Malasia. Arch Neurol 1988, 45:624-627.
22. Visscher BR, Liu KS, Clarck VA, Detels R, Malmgren RM, Dudley JP. Onset symptoms as predictors of mortality and disability in multiple sclerosis. Acta Neurol Scand 1984, 70:321-328.

Datas de Publicação

Publicação nesta coleção
20 Jan 2011
Data do Fascículo
Jun 1995

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Allison RS. Survival in disseminated sclerosis: a clinical study of a series of cases first seen twenty years ago. Brain 1950, 73:103-115.

[2] 2. Alter M, Halpern L, Kurland L, Bornstein B, Leibowitz U, Silberstein J. Multiple sclerosis in Israel: prevalence among immigrants and native inhabitants. Arch Neurol 1962, 7:253-263.

[3] 3. Bauer HJ. Problems of symptomatic therapy of multiple sclerosis. Neurology 1978, 28:8-20.

[4] 4. Bernardi S, Buttinelli C, Grasso MG, Millefiorni E, Pace A, Prencipe M, Fieschi C. Evolution and severity markers in 233 multiple sclerosis patients. Riv Neurol 1987, 57:197-200.

[5] 5. Callegaro D. Contribuiçăo do estudo clínico evolutivo da esclerose múltipla: análise de 120 pacientes. Tese de Doutorado, Faculdade de Medicina da Universidade de Săo Paulo. Săo Paulo 1989.

[6] 6. Callegaro D, Lolio CA, Radvany J, Tilbery CP, Mendonça RA, Melo ACP. Prevalence of multiple sclerosis in the city of Săo Paulo, Brazil, in 1990. Neuroepidemiology 1992, 11:11-14.

[7] 7. Confavreux C, Aimard G, Devic M. Course and prognosis of multiple sclerosis: computerized data processing of 349 patients. Brain 1980, 103:281-300.

[8] 8. Dean G. Epidemiology of multiple sclerosis. Neuroepidemiology 1984, 3:58-73.

[9] 9. Detels R, Visscher BR, Malmgren RM, Coulson AM, Lucia MV, Dudley JP. Evidence for lower susceptibility to multiple sclerosis in Japanese-Americans. Am J Epidemiol 1977, 106:303-310.

[10] 10. Detels R, Clark VA, Valdiviezo NL, Visscher BR, Malmgren RM, Dudley JP. Factors associated with a rapid course of multiple sclerosis. Arch Neurol 1982, 39:337-341.

[11] 11. Granieri E, Tola R, Paolino E, Rosati G, Carreras M, Moneti VC. The frequency of multiple sclerosis in Italy: a descriptive study in Fevrana. Ann Neurol 1985, 1:80-84.

[12] 12. Kuroiwa Y. Nationwide survery of MS in Japan. Neurology 1975, 25:845-851.

[13] 13. Kurtzke JF, Beebe GW, Dagler B, Auth TL, Kurland LT, Defzger MD. Studies on the natural history of multiple sclerosis: clinical and laboratory findings at first diagnoses. Acta Neurol Scand 1972, 48:19-46.

[14] 14. Lana-Peixoto MA, Lana-Peixoto MI. Is multiple sclerosis in Brazil and Asia alike? Arq Neuropsiquiatr 1992, 50:419-425.

[15] 15. Lauer K, Firnhaber W, Reining R, Leuchtweis B. Epidemiological investigations into multiple sclerosis in southern Hesse: I. Methodological problems and basic epidemiologic characteristics. Acta Neurol Scand 1984, 70:257-265.

[16] 16. Leibowitz V, Antonovski H, Katz R, Alter M. Does pregnancy increase the risk of multiple sclerosis? J Neurol Neurosurg Psychiatry 1967, 30:354-357.

[17] 17. Leite ACCB, Andrade C, Novis S. Esclerose múltipla no Rio de Janeiro: apresentaçăo clínica em 51 casos. Arq Neuropsiquiatr 1990, 48 (Supl): 66 A.

[18] 18. Mackay RP, Hirano A. Forms of benign multiple sclerosis: report of two "clinical silent cases" discovery at autopsy. Arch Neurol 1967, 17:588-600.

[19] 19. Papaiz-Alvarenga RM, Santos CMM, Bernardini JSA, Camargo SMGG. Esclerose múltipla: perfil clínico e epidemiológico no Rio de Janeiro. Arq Neuropsiquiatr 1990, 48 (Supl): 63 A.

[20] 20. Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC, Johnson KP, Silberg DH, Tourtellote WW. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983, 227-231.

[21] 21. Tan CT. Multiple sclerosis in Malasia. Arch Neurol 1988, 45:624-627.

[22] 22. Visscher BR, Liu KS, Clarck VA, Detels R, Malmgren RM, Dudley JP. Onset symptoms as predictors of mortality and disability in multiple sclerosis. Acta Neurol Scand 1984, 70:321-328.