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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.4 São Paulo Dec. 1995 

Hepatic enzymes' level during chronic use of anticonvulsant drugs


Dosagens de enzimas hepáticas em pacientes em uso crônico de drogas antiepiléticas



Mauricio HoshinoI; Carlos Otto HeiseI; Paulo PugliaI; Arlete B.B. AlmeidaI; Arthur CukiertII

IM.D., Resident. Department of Neurology and Neurosurgery, University of São Paulo School of Medicine, São Paulo, Brazil
IIM.D., Assistant. Department of Neurology and Neurosurgery, University of São Paulo School of Medicine, São Paulo, Brazil




We studied retrospectively 894 adult epileptic patients treated during the period from 1983 to 1992. Hepatic enzymes abnormal values were seen in 49%(n=438). In 22.3%(n=200), at least 2 enzyme levels in different moments were altered. They were divided in three groups: GI with alterations at transaminases (3%, n=6), GII with alterations at GGT and AP enzymes (72%,n=144) and GIII with alterations in both groups (25%, n=50). No patient developed clinical symptoms of liver disease. The increase of gamma-glutamil-transferase (GGT) and alkaline phosphatase (AP) levels is frequent and not necessarily pathological. Slight increase of transaminases can occur with no clinical correlation. The routine screening of hepatic enzymes level during the chronic use of anticonvulsivant drugs in adults has a questionable value.

Key words:hepatic enzymes, epilepsy, anticonvulsant drugs.


Oitocentos e noventa e quatro pacientes epiléticos adultos tratados no período de 1983 a 1992 foram estudados retrospectivamente. Valores anormais de enzimas hepáticas foram detectados em 49% (n=438) dos casos. Em 200 pacientes (22,3%), ao menos duas dosagens obtidas em momentos diferentes estavam alteradas. Estes últimos foram divididos em 3 grupos: GI, com alterações de transaminases (3%, n=6); GII com alterações de gama-glutamil-transferase (GGT) e fosfatase alcalina (AP) (72%, n=144) e GIII com alterações nos dois grupos de enzimas (25%, n=50). Nenhum paciente desenvolveu sinais ou sintomas de doença hepática. O aumento de GGT e AP em pacientes em uso de drogas antiepiléticas é frequente e pode não ter significado patológico. Pequenos aumentos de transaminases também podem ocorrer sem correlação clínica.

Palavras-chave: enzimas hepáticas, epilepsia, drogas antiepiléticas.



Texto completo disponível apenas em PDF.

Full text available only in PDF format.




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Aceite: 15-maio-1995.

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