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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.4 São Paulo Dec. 1995

http://dx.doi.org/10.1590/S0004-282X1995000500003 

Comparação das frações HDL e LDL colesterol como fatores de risco para a aterosclerose carotídea

 

Comparative study of HDL and LDL cholesterol as risk factors for carotid atherosclerosis

 

 

Rubens José GagliardiI; Marsal SanchesII; Zied RasslanIII; Marilda Lauretti S. GuedesIV

IProfessor Adjunto- Doutor, responsável pela Liga da Aterosclerose
IIInterno (6 ano)
IIIProfessor Instrutor do Departamento de Clínica Médica
IVProfessora Adjunta, chefe da Disciplina de Bioestatística (Departamento de Medicina Social)

 

 


RESUMO

Estudo prospectivo com o objetivo de verificar qual das frações do colesterol sanguíneo, HDL ou LDL, é mais significativa para o desenvolvimento da aterosclerose das artérias carótidas (AC). Constou de 125 indivíduos de ambos os sexos, com idade entre 45 a 75 anos, incluídos aleatoriamente. Em todos foi procedida a dosagem sanguínea do colesterol total e das frações HDL e LDL e estudo ultrassonográfico (através de ultrassonografia modo B) das AC. Os resultados mostraram que a presença de placa de ateroma, com ou sem estenose nas AC, é inversamente proporcional aos níveis de HDL. Estes achados foram estatisticamente significantes (x2=6,57 e x2=9,24, respectivamente para placa sem estenose e com estenose; x2 crítico = 5,99 para α=5%) . Foi também constatada associação entre a presença de placa aterosclerótica na AC e níveis sangüíneos elevados de LDL: quanto maiores os níveis de LDL, maior a proporção de indivíduos com placas, porém este achado não foi estatisticamente significante (x2=0,97, x2 crítico 5,99 para α =5%). Não foi encontrada nesta casuística relação entre níveis elevados de LDL e presença de estenose nas AC. Estes resultados, ainda que iniciais, sugerem que níveis baixos de HDL são mais aterogênicos para as AC comparativamente a níveis elevados de LDL.

Palavras Chave: aterosclerose, estenose, colesterol, artéria carótida.


SUMMARY

In order to find out whether there exists a relationship between HDL and LDL serum levels and atherosclerotic plaques in the carotid artery (CA), a prospective study was carried out involving 125 patients. They were aleatorily included, of both sexes and age between 45-75 years old. HDL and LDL serum levels were measured as well CA ultrasonographic mode B investigated. It was verified that the number of patients having atherosclerotic plaques in CA was inversely proportional to the HDL levels. We came up with the same ratio when the HDL levels were compared to the number of patients having CA stenosis. These results were statistically signifcant (x2=6.57 and x2=9.24 respectively; critical x2=5.99 to α =5%). A direct ratio was also found out in the relationship between the presence of atherosclerotic plaques in the CA and the LDL serum levels (greater in patients with plaques). However no relationship between LDL levels and the occurrence or not of CA stenosis in patients having plaques was demonstrated. The results were not statistically significant (x2=0.97 and x2=0.41, respectively, critical x2=5.99 to α =5%). The obtained results seem to be at least in part in agreement with literature findings. Statistically significative results in the comparison of HDL and LDL levels with the grade of stenosis of the CA were not found out (x2=11.78 and x2=4.03, respectively; critical x2=12.59 to α =5%).

Key words:atherosclerosis, stenosis, cholesterol, carotid artery.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Dr. Rubens José Gagliardi - Disciplina de Neurologia, Faculdade de Ciências Médicas da Santa Casa de São Paulo - Rua Cesário Morta Jr. 122 - 01222-001 São Paulo SP - Brasil. Fax 001 8261288.

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