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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.4 São Paulo Dec. 1995

https://doi.org/10.1590/S0004-282X1995000500007 

Adenosino-deaminase no líquido celalorraqueano de pacientes com a síndrome da imunodeficiência adquirida

 

Adenosine-deaminase in the cerebrospinal fluid of patients with the acquired immunodeficiency syndrome

 

 

Luís Dos Ramos MachadoI; José Antonio LivramentoII; Antonio Spina-FrançaIII

IProfessor Assistente do Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo
IIProfessor Docente-Livre do Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo
III
Professor Titular Emérito do Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo

 

 


RESUMO

A determinação da atividade enzimática da adenosino-deaminase (ADA) no líquido cefalorraqueano (LCR) de pacientes com síndrome da imunodeficiência adquirida (AIDS) pode sinalizar, ainda que de modo inespecífico, a atividade de patologias associadas. Os níveis de atividade de ADA, estudados no LCR de 263 pacientes, estavam aumentados naqueles com patologias associadas em relação aos controles normais e em relação aos pacientes com AIDS que não apresentam alterações ao exame de LCR. No entanto, os níveis de ADA detectados no LCR não apresentaram diferença estatística ao se considerarem os seguintes grupos de pacientes distribuídos segundo os achados no próprio LCR: com anticorpos para toxoplasmose, sífilis ou citomegalovírus; com C. neoformans ou seus antígenos; com bacilos álcool-ácido-resistentes; com linfomas.

Palavras-chave:adenosino-deaminase, líquido cefalorraqueano, AIDS (SIDA), citomegalovírus, criptococose, sífilis, toxoplasmose, tuberculose, linfoma.


SUMMARY

The adenosine-deaminase (ADA) activity was evaluated in CSF samples from 263 patients with AIDS. An elevated ADA activity in CSF was found in patients with: antibodies to toxoplasmosis, syphilis or cytomegalovirus; Cryptococcus neoformans or their antigens; tuberculous meningitis; lymphoma. There was no statistical difference among all these groups in respect to ADA activity. However, the ADA activity in CSF from AIDS patients without CSF changes other than HIV antibodies, even unspecific changes, was not elevated. This may suggest that ADA is related to AIDS associated pathologies activity rather than to HIV infection itself.

Key-words: adenosine-deaminase, cerebrospinal fluid, AIDS, cytomegalovirus, cryptococosis, toxoplasmosis, tuberculous meningitis, syphilis, lymphoma.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Aceite: 27-julho-1995

 

 

Dr. Luís dos Ramos Machado - Praça Amadeu Amaral 47 conj 33 - 01327-010 São Paulo SP - Brasil. FAX 011 289 8879

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