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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.53 no.4 São Paulo Dec. 1995

https://doi.org/10.1590/S0004-282X1995000500010 

HTLV-I Associated myelopathy in porto alegre (southern Brazil)

 

Mielopatia associada ao HTLV-I em Porto Alegre (Sul do Brasil)

 

 

Márcio Menna-BarretoI; Alexandre DovalI; Giorgio RabolinII; Otomar BianchiniI, II

IUnidade de Neuroretrovirologia do HTLV (Clínica Virion) do Hospital Porto Alegre
IILaboratório Bianchini & Jardim de Análises Clínicas

 

 


SUMMARY

HTLV-I associated myelopathy/tropical spastic paraparesis (TSP/HAM) have been increasingly described in practically all regions of Brazil. Five confirmed and documented cases of patients with TSP/HAM in Rio Grande do Sul are reported; in all of them spastic paraparesis, neurogenic bladder and superficial and/or profound sensitive disorders were observed in variable degrees. One patient presented a relapsing-remitting course with a cerebellar ataxia (multiple sclerosis-like pattern). Everyone was submitted to clinical, serological, urodynamic, neurophysiologic and neuroradiologic investigation. The aim of this study was to present the southern region of Brazil as an area with significant endemicity for HTLV-I/II infection (prevalence of 0.42% between blood donors), and also to show the existence of patients with neurologic disease associated with this retrovirus.

Key words:HTLV-I, myelopathy, tropical spastic paraparesis, neurogenic bladder, TSP/HAM, multiple sclerosis, Brazil.


RESUMO

Mielopatia associada ao HTLV-I/paraparesia espástica tropical (TSP/HAM) tem sido descrita de forma crescente em praticamente todas as regiões do Brasil. Relatam-se cinco casos confirmados e documentados de pacientes com TSP/HAM no Rio Grande do Sul, observando-se em todos paraparesia espástica, bexiga neurogênica e distúrbios sensitivos superficiais e/ou profundos de graus variáveis. Em um caso denotou-se padrão em surto e remissão, caracterizado por ataxia cerebelar (sugestivo de esclerose múltipla). Os cinco pacientes foram submetidos a investigação clínica, laboratorial, urodinâmica, neurofisiológicae de neuroimagem. O objetivo do presente trabalho foi apresentar a região sul do Brasil como uma área de significativa endemicidade de infecção por HTLV-I/II (0,42% de prevalência entre doadores de sangue), bem como evidenciar a existência de pacientes com doença neurológica associada a este retrovirus.

Palavras-chave: HTLV-I, mielopatia, paraparesia espástica tropical, bexiga neurogênica, PET/ MAH, esclerose múltipla, Brasil.


 

 

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Aceite: 27-junho-1995.

 

 

Dr. Márcio Menna-Barreto - Rua Felipe Nery 296 sala 201 - 90440-150 Porto Alegre RS - Brasil .FAX 55 51 331 1085.

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