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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.54 no.1 São Paulo Mar. 1996

http://dx.doi.org/10.1590/S0004-282X1996000100006 

Rural or urban living and Parkinson's disease

 

Antecedente de vida rural ou de vida urbana e doença de Parkinson

 

 

Henrique B. FerrazI; Luiz A. F. AndradeI; Vítor TumasII; Leandro C. CaliaI; Vanderci BorgesI

IMovement Disorders Unit, Department of Neurology and Neurosurgery, Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), São Paulo - Brazil
IIDepartment of Neurology, Psychiatry and Medical Psychology, Faculdade de Medicina da Universidade de São Paulo -Ribeirão Preto (FMUSP-RP), Ribeirão Preto - Brazil

 

 


ABSTRACT

Although the precise etiology of Parkinson's disease (PD) is as yet unknown, it appears that certain environmental factors are involved. Prior living in a rural area has been implicated as a possible risk factor for PD, particularly in the early onset type. We evaluated the role of previous living conditions in the clinical correlates and outcome characteristics of 118 PD patients. All of them were seen from January 1987 to October 1992. The Rural Group (RG) comprised 71 patients (60.2%) who had lived in the rural area for at least 10 years (mainly in early phase of life) and the Urban Group (UG) consisted of 47 patients (39.8%) who had lived their entire life in an urban environment. The average age at the beginning of the symptoms was 58.8 in the RG and 54.1 in the UG. The mixed form of the disease (tremor, rigidity and akinesia) was the most frequent in both groups. A minimum 6-month follow-up period was undertaken with 63 patients (average 20 months) and no difference in response to treatment or in progression of the illness was detected between the two groups. Our data show that the previous living environment does not appear to be a determining factor in either the clinical or outcome characteristics of PD.

Key words:Parkinson's disease epidemiology, Parkinson's disease etiology, environmental factors.


RESUMO

A etiologia da doença de Parkinson (DP) é ainda desconhecida mas parece que fatores ambientais podem estar envolvidos. A incidência da DP, particularmente a de início precoce, parece ser maior em indivíduos com antecedente de moradia na zona rural. Avaliamos as características clínicas e a progressão da DP em 118 pacientes segundo os antecedentes de área de moradia pregressa. Havia 71 pacientes (60,2%) com antecedente de no mínimo 10 anos na zona rural (especialmente nas fases iniciais da vida), o chamado Grupo Rural (GR), e 47 pacientes (39,8%) que tiveram antecedente de vida exclusivamente urbana, o chamado Grupo Urbano (GU). A média de idade de início dos sintomas foi 58,8 anos no GR e de 54,1 anos no GU. A forma mista da DP (com tremor, bradicinesia e rigidez) foi a mais frequente em ambos os grupos. Um período de acompanhamento de no mínimo 6 meses foi obtido em 63 pacientes (média de 20 meses de acompanhamento) e a progressão da sintomatologia foi semelhante nos dois grupos (GR e GU). Nossos dados indicam que o antecedente de moradia não parece ser determinante para o padrão de manifestação clínica e de evolução da DP.

Palavras-chave: doença de Parkinson, epidemiologia; doença de Parkinson, etiologia; fatores ambientais.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Aceite: 17-outubro-1995.

 

 

Dr. Henrique B. Ferraz - Al. Casa Branca 799 apto 72 - 01408-001 São Paulo SP - Brasil.