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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.54 no.1 São Paulo Mar. 1996

https://doi.org/10.1590/S0004-282X1996000100016 

Local IgG synthesis in three pediatric patients with cuban epidemic neuropathy

 

Sintesis local de IgG en tres pacientes pediátricos com neuropatía epidêmica cubana

 

 

Alberto Dorta-ContrerasI; Eric Martínez TorresII; Carlos Dotres-MartínezII

ILaboratório Inmunología, Hospital Pediátrico San Miguel, Ciudad de La Habana, Cuba
IIHospital Wiliam Soler, Ciudad de La Habana, Cuba

 

 


ABSTRACT

Three pediatric patients with Cuban epidemic neuropathy were studied. Cerebrospinal fluid and sera were simultaneously obtained. Albumin and IgG were quantified by immunodifusion. Albumin quotient and local synthesis of IgG were calculated by Reiber/Felgenhauer formula. A patient with optic neuritis had a dysfunction of the blood-cerebrospinal fluid barrier. All the group had local synthesis of IgG.

Key words:Cuban epidemic neuropathy, optic neuritis, peripheral neuropathy, cerebrospinal fluid, intrathecal synthesis.


RESUMEN

Se estudiaron tres pacientes pediátricos con neuropatia epidêmica cubana. Se obtuvieron suero y liquido cefalorraquídeo simultaneamente. Se cuantificaran los niveles de albúmina e IgG por inmunodifusion radial. Se calculo la razón albúmina y la fórmula de Reiber/Felgenhauer. Un paciente con neuritis óptica tuvo una disfunción de la barrera sangre-líquido cefaloraquídeo. Todo el grupo tuvo síntesis local de IgG.

Palabras Claves: neuropatía epidêmica cubana, neuritis óptica, neuropatía periférica, líquido cefalorraquídeo, IgG, albúmina, síntesis intratecal.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

REFERENCES

1. Dorta-Contreras AJ, Garcia-Fernandez L, Gil Chaviano M. Neuroimunolab: sistema para la evaluación de la respuesta inmune en el sistema nervioso central. Rev Cubana Invest Biomed 1991; 10:155.         [ Links ]

2. Hernandez A, León E, San Martin M, Alfonso A. Relations between the results of the immunologic and electrophysiologic studies on a group of patients with epidemic optic neuropathy (Abstract). Habana: Round table on the development of neuroscience in the Caribbean, 1993:3.         [ Links ]

3. Krajewski S, Szablowska-Krajewska M. Disseminated vasculomyelopathy in the peripheral nervous system mediated by immune complexes (ICs). Neurol Sci 1986; 72:131-136.         [ Links ]

4. Llanes G, Asher D, Brown P, Gadjdusek DC, Marquez M, Muci-Mendonza R, Roman GC, Silva JC, Spencer PS, Thylefors B. Neuropatia epidêmica en Cuba. Bol Epidemiol OPS 1993; 14:1-4.         [ Links ]

5. OPS. Neuropatia epidêmica cubana: una actualización. Bol Epidemiol OPS 1994; 15:7.         [ Links ]

6. Prange H, Moskophidis M, Schipper HI, Mueller F. Relationship between neurological features and intrathecal synthesis of IgG antibodies to Treponema pallidum in untreated and treated human neurosyphilis. J Neurol 1994; 230:241-252.         [ Links ]

7. Reiber H. Flow rate of cerebrospinal fluid (CSF): a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases. J Neurol Sci 1994; 122:189-203.         [ Links ]

8. Reiber H, Felgenhauer K. Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chem Acta 1987; 163:319-328.         [ Links ]

 

 

Aceite: 16-setembro-1995.

 

 

Dr. Alberto Dorta-Contreras - Laboratório Inmunologia, Hospital Pediátrico San Miguel - Apartado 10049 -11000 Ciudad de La Habana - Cuba.

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