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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.54 no.2 São Paulo June 1996

http://dx.doi.org/10.1590/S0004-282X1996000200012 

Corpos de inclusão citoplasmática: estudo em diversas doenças e revisão da literatura

 

Inclusion cytoplasmic bodies: a study in several diseases and a literature review

 

 

Rosana Herminia ScolaI; Lineu Cesar WerneckII; Célia Regina Cavichiolo FrancoIII

IProfessora Assistente
IIProfessor Titular
IIIAuxiliar de Ensino de Biologia

 

 


RESUMO

Estudamos 16 casos entre 1400 biópsias musculares que apresentavam vacúolos marginados, cujo aspecto histológico sugeria corpos de inclusão citoplasmáticos. Procuramos correlacionar os dados clínicos, laboratoriais e histopatológicos, a fim de determinar a especificidade dos corpos de inclusão citoplasmáticos para determinadas doenças. A creatinaquinase mostrou-se elevada em 10 casos. A eletromiografia foi anormal em todos os casos. A histoquímica muscular em 5 casos revelou uma miopatia, em 7 padrão misto, em dois desinervação e em 2 casos miopatia inflamatória. A microscopia eletrônica demonstrou a presença de filamentos em 8 casos (nucleares, dispersos no citoplasma ou na região subsarcolemal). Os pacientes foram classificados conforme a história clínica, hereditariedade, dados laboratoriais, eletrofisiológicos, histoquímicos e microscopia eletrônica Encontramos miosite com corpos de inclusão citoplasmática (4 casos), atrofia muscular espinhal juvenil (6 casos), miopatias distais (3 casos), distrofia de cinturas pélvica e escapular (2 casos) e polineuropatia periférica (1 caso). Apresentamos revisão sobre a patogenia, formação e possível etiologia dos vacúolos marginados e sua relação com as diversas entidades em que foram detectados, sugerindo que não são específicos para uma única doença.

Palavras-chave: corpos de inclusão citoplasmática, vacúolos marginados, miosite com corpos de inclusão citoplasmática, atrofia muscular espinhal juvenil, miopatias distais, distrofias de cinturas pélvica e escapular.


ABSTRACT

Among 1400 muscle biopsies, we studied 16 cases with rimmed vacuoles, whose histology suggests cytoplasm inclusion bodies. We tried to correlate the clinical, laboratory and histopatological data in order to verify the specificity of cytoplasm inclusion bodies to certain diseases. The creatinekinase was increased in 10 cases. In all cases electromyography was abnormal. Muscle histochemistry revealed myopathy in 5 cases, mixed pattern in 7, denervation in 2 and in 2 cases, inflammatory myopathy. Electron microscopy showed the presence of filaments in 8 cases (nuclear, disseminated in cytoplasm or in the subsarcolemmal region). The patients were classified according to history, heredity, laboratory, electrophysiologic, histochemistry data and electron microscopy: in myositis with inclusion cytoplasmic bodies (4 cases), juvenile spinal muscular atrophy (6 cases), distal myopathies (3 cases), limb-girdle dystrophy (2 cases) and peripheral neuropathy (1 case). We present a revision on the pathogenesis and possible etiology of rimmed vacuoles and their relationship with several diseases.

Key words: cytoplasmic inclusion bodies; rimmed vacuoles, inclusion body myositis, juvenile spinal muscular atrophy, distal myopathies, limb-girdle muscular dystrophy.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

Agradecimentos - Agradecemos ao Dr. Guilberto Minghetti pelo auxílio na interpretação das microscopias eletrônicas e às Sitas. Sumico Nakagawa e Angela Chiquito pela colaboração técnica.

 

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Aceite: 12-janeiro-1996.

 

 

Estudo realizado no Serviço de Doenças Neuromusculares, Especialidade de Neurologia e Propedêutica Médica do Hospital de Clínicas e Departamento de Morfologia da Universidade Federal do Paraná, Curitiba
Dra. Rosana Herminia Scola - Serviço de Doenças Neuromusculares, Hospital de Clínicas da UFPR - Rua General Carneiro 181 3º andar - 80069-155 Curitiba PR - Brasil.

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