Genetics in multiple sclerosis: twin studies

Rezende, Patrícia Almeida De; Arruda, Walter Oleschko

doi:10.1590/S0004-282X1996000300012

Abstracts

The authors make a review and critical analysis of twin studies in multiple sclerosis (MS). The concordance rate among homozygotic twins is significantly greater than in heterozygotic twins. The average herdability in MS is about 28%; no single gene was identified as a sole risk factor for the development of the disease. MS may be considered a poligenic disease triggered by environmental factors in a genetically predisposed individual.

multiple sclerosis; twin studies; genetics

Foi feita análise crítica dos estudos em gêmeos realizados na esclerose múltipla (EM). A taxa de concordância em gêmeos monozigóticos é significativamente maior do que em gêmeos dizigóticos. A média da herdabilidade da EM foi estimada em aproximadamente 28%; porém ainda não foram identificados os genes que constituem fator de risco para o desenvolvimento da EM. A EM pode ser considerada uma doença poligênica desencadeada por fatores ambientais em indivíduo geneticamente suscetível.

esclerose múltipla; gêmeos; genética

Aspectos genéticos da esclerose múltipla: I. estudos em gêmeos

Genetics in multiple sclerosis: twin studies

Patrícia Almeida De Rezende^I; Walter Oleschko Arruda^II

^IMestre em Genética, Universidade Federal do Paraná (UFPR)

^IINeurologista

RESUMO

Foi feita análise crítica dos estudos em gêmeos realizados na esclerose múltipla (EM). A taxa de concordância em gêmeos monozigóticos é significativamente maior do que em gêmeos dizigóticos. A média da herdabilidade da EM foi estimada em aproximadamente 28%; porém ainda não foram identificados os genes que constituem fator de risco para o desenvolvimento da EM. A EM pode ser considerada uma doença poligênica desencadeada por fatores ambientais em indivíduo geneticamente suscetível.

Palavras-chave: esclerose múltipla, gêmeos, genética.

ABSTRACT

The authors make a review and critical analysis of twin studies in multiple sclerosis (MS). The concordance rate among homozygotic twins is significantly greater than in heterozygotic twins. The average herdability in MS is about 28%; no single gene was identified as a sole risk factor for the development of the disease. MS may be considered a poligenic disease triggered by environmental factors in a genetically predisposed individual.

Key words: multiple sclerosis, twin studies, genetics.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite:14-março-1996.

Dr. Walter O. Arruda - Rua Gonçalves Dias 713 - 80240-340 Curitiba PR - Brasil.

1. Beiguelman B. Dinâmica dos genes nas famílias e nas populações. Ribeirão Preto: SBG 1994.
2. Bobowick A, Kurtzke JF, Brody A, Hrubec Z, Gillespie M. Twin study of multiple sclerosis: an epidemiologic inquiry. Neurology 1978;28:978-987.
3. Cavalli-Sforza LL, Bodmer WF. The genetics of human populations. São Francisco:Freeman, 1971.
4. Cendrowski WS. Multiple sclerosis: discordance in three pairs of dyzigotic twins. J Med Genet 1968;5:266-268.
5. Currier RD, Eldridge R. Possible risk factors in multiple sclerosis as found in a national twin study. Arch Neurol 1982;39:140-144.
6. Ebers GC, Bulman DE, Sadovnick AD, Paty DW, Warren S, Hade W, Murray TJ, Seland TP, Duquete P, Grey T, Nelson R, Nicolle M, Brunet D. A population-based study of multple sclerosis in twins. N Engl J Med 1986,315:1638-1642.
7. French Research Group on Multiple Sclerosis. Multiple sclerosis in 54 twinships: concordance rate is independent of zygosity. Ann Neurol 1992;32:724-727.
8. Heltberg A, Holm NV. Concordance in twins and recurrence in sibships in multiple sclerosis. Lancet 1982; 1:1068.
9. Kinnunen E, Juntunen J, Ketonen L, Koskimies S, Konttinen YT, Salmi T, Koskenvuo M, Kaprio J. Genetic susceptibility to multiple sclerosis: a co-twin study of a nation-wide series. Arch Neurol 1988;45:1108-1 111.
10. MacKay RP, Myrianthopoulos NC. Multiple sclerosis in twins and their relatives. Arch Neurol 1966;15:449-462.
11. Matthews HB, Compston A, Allen IV, Martyn CN. McAlpine's multiple sclerosis. Ed2. New York: Churchill Livingstone, 1991.
12. Mumford CJ, Wood NW, Kellar-Wood H, Thorpe JW, Miller DH, Comston DAS. The Biritish isles survey of multiple sclerosis in twins. Neurology 1994;44:11-15.
13. Poser CM. Multiple sclerosis: diagnosis and treatment. Med Principles Pract 1992;3:1-16.
14. Sadovnick AD, Armstrong H, Rice GPA, Bulman D, Hashimoto L, Paty DW, Hashimoto SA, Warren S, Hader W, Murray TJ, Seland TP, Metz L, Bell R, Duqette P, Gray T, Nelson R, Weinshenker B, Brunet D, Ebers GC. A population-based study of multiple sclerosis in twins: update. Ann Neurol 1993;33:281-285.
15. Short S. Statistics for health professionals. Philadelphia: Saunders, 1990.
16. Williams A, Eldridge R, McFarland H, Houff S, Krebs H, McFarlin D. Multiple sclerosis in twins. Neurology 1980;30:1139-1147.

Publication Dates

Publication in this collection
10 Nov 2010
Date of issue
Sept 1996

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Beiguelman B. Dinâmica dos genes nas famílias e nas populações. Ribeirão Preto: SBG 1994.

[2] 2. Bobowick A, Kurtzke JF, Brody A, Hrubec Z, Gillespie M. Twin study of multiple sclerosis: an epidemiologic inquiry. Neurology 1978;28:978-987.

[3] 3. Cavalli-Sforza LL, Bodmer WF. The genetics of human populations. São Francisco:Freeman, 1971.

[4] 4. Cendrowski WS. Multiple sclerosis: discordance in three pairs of dyzigotic twins. J Med Genet 1968;5:266-268.

[5] 5. Currier RD, Eldridge R. Possible risk factors in multiple sclerosis as found in a national twin study. Arch Neurol 1982;39:140-144.

[6] 6. Ebers GC, Bulman DE, Sadovnick AD, Paty DW, Warren S, Hade W, Murray TJ, Seland TP, Duquete P, Grey T, Nelson R, Nicolle M, Brunet D. A population-based study of multple sclerosis in twins. N Engl J Med 1986,315:1638-1642.

[7] 7. French Research Group on Multiple Sclerosis. Multiple sclerosis in 54 twinships: concordance rate is independent of zygosity. Ann Neurol 1992;32:724-727.

[8] 8. Heltberg A, Holm NV. Concordance in twins and recurrence in sibships in multiple sclerosis. Lancet 1982; 1:1068.

[9] 9. Kinnunen E, Juntunen J, Ketonen L, Koskimies S, Konttinen YT, Salmi T, Koskenvuo M, Kaprio J. Genetic susceptibility to multiple sclerosis: a co-twin study of a nation-wide series. Arch Neurol 1988;45:1108-1 111.

[10] 10. MacKay RP, Myrianthopoulos NC. Multiple sclerosis in twins and their relatives. Arch Neurol 1966;15:449-462.

[11] 11. Matthews HB, Compston A, Allen IV, Martyn CN. McAlpine's multiple sclerosis. Ed2. New York: Churchill Livingstone, 1991.

[12] 12. Mumford CJ, Wood NW, Kellar-Wood H, Thorpe JW, Miller DH, Comston DAS. The Biritish isles survey of multiple sclerosis in twins. Neurology 1994;44:11-15.

[13] 13. Poser CM. Multiple sclerosis: diagnosis and treatment. Med Principles Pract 1992;3:1-16.

[14] 14. Sadovnick AD, Armstrong H, Rice GPA, Bulman D, Hashimoto L, Paty DW, Hashimoto SA, Warren S, Hader W, Murray TJ, Seland TP, Metz L, Bell R, Duqette P, Gray T, Nelson R, Weinshenker B, Brunet D, Ebers GC. A population-based study of multiple sclerosis in twins: update. Ann Neurol 1993;33:281-285.

[15] 15. Short S. Statistics for health professionals. Philadelphia: Saunders, 1990.

[16] 16. Williams A, Eldridge R, McFarland H, Houff S, Krebs H, McFarlin D. Multiple sclerosis in twins. Neurology 1980;30:1139-1147.