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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.54 no.4 São Paulo Dec. 1996

http://dx.doi.org/10.1590/S0004-282X1996000400006 

Anticorpos antifosfolípides em 66 pacientes com infarto cerebral entre 15 e 40 anos

 

Antiphospholipid antibodies in 66 patients with cerebral infarction between 15 and 40 years old

 

 

José Ibiapina Siqueira NetoI; Antonio C. SantosII; Soraia R. Cabette FábioIII; Américo C. SakamotoIV

IM.D., Professor Adjunto Doutor do Departamento de Medicina Clínica da Universidade Federal do Ceará
IIM.D., Professor Assistente de Neurorradiologia do Departamento de Clínica Médica da Faculdade de Medicina de Ribeirão Preto (FMRP) da Universidade de São Paulo (USP)
IIIM.D., Médica Assistente do Departamento de Neurologia, Psiquiatria e Psicologia Médica da FMRP/USP
IVM.D., Professor Associado do Departamento de Neurologia, Psiquiatria e Psicologia Médica da FMRP/USP

 

 


RESUMO

Os anticorpos antifosfolípides (aFLs) constituem grupo heterogêneo de imunoglobulinas que tem sido relacionado com alterações na coagulabilidade. Indivíduos com títulos elevados teriam maior probabilidade de desenvolver tromboses de repetição, tanto arterial como venosa, e por conseguinte infarto cerebral (IC). Os testes para detecção mais utilizados em estudos clínicos são o inibidor lúpico e a anticardiolipina. Têm-se relatado maiores percentuais de positividade nesses testes em pacientes jovens com IC. Neste estudo procuramos investigar a prevalência desses anticorpos em pacientes com IC entre 15 e 40 anos em nosso Serviço. Examinamos 66 pacientes para presença de aFLs e obtivemos 16,65% de resultados positivos. Confirmamos diagnóstico de síndrome do anticorpo antifosfolípide primária em três (4,55%) casos. Concluímos que a pesquisa de rotina para aFLs em pacientes jovens com IC está indicada neste grupo de pacientes, mas correlacioná-los com o episódio isquêmico nem sempre é possível.

Palavras-chave: infarto cerebral, anticorpos antifosfolípides, hipercoagulabilidade.


ABSTRACT

The antiphospholipid antibodies (aPLs) are a heterogenous group of immunoglobulins that have been related with alterations in blood coagulability in recent years. Patients with elevated titers of these antibodies have a high probability to develop thrombotic events, including cerebral infarct (CI). The tests currently used to detect these antibodies are the lupus anticoagulant and ELISA for anticardiolipin antibodies which have a larger proportion of positivity among young patients with CI. In our study we tested 66 patients with cerebral infarcts whose ages ranged from 15 to 40 years for the presence of lupus anticoagulant and anticardiolipin antibodies. The results showed that eleven (16.65%) patients were positive for aPLs and three (4.55%) of them fulfilled the diagnostic criteria for primary antiphospholipid syndrome. These data point out to the importance of investigating aPLs in young patients with CI and its high prevalence in this group compared with healthy population.

Key words: antiphospholipid antibodies, cerebral infarcts, hypercoagulation states.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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Aceite: 13-maio-1996.

 

 

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