Tumores pediátricos primários do sistema nervoso central: estudo anatomopatológico de 623 casos

Torres, Luiz Fernando Bleggi; Jacob, Graciela Vanessa Vicelli; Reis-Filho, Jorge Sérgio; Noronha, Lúcia de

doi:10.1590/S0004-282X1997000500017

Resumos

Tumores primários do sistema nervoso central (SNC) representam a segunda mais freqüente forma de neoplasia em crianças abaixo dos 15 anos, entretanto são as principais neoplasias responsáveis pelo óbito. Os autores relatam a análise epidemiológica e histopatológica de 623 tumores primários do SNC que acometeram pacientes pediátricos no período de 1990 a 1996 na cidade de Curitiba- PR. Neste período foram analisadas 3318 biópsias de SNC. Do total, 623 eram provenientes de neoplasias acometendo pacientes pediátricos (18,7%). As idades dos pacientes variaram de S meses a 15 anos, sendo que 325 tumores ocorreram no sexo masculino e 298 no sexo feminino. Grande parte dos tumores localizava-se na fossa posterior. Dos 623 tumores, 277 eram de origem glial. As mais freqüentes foram: astrocitoma (27,9%), meduloblastoma (9,95%), craniofaringioma (5,93%), ependimoma (4,97%) e glioblastoma (3,37%).

tumores cerebrais; infância; sistema nervoso central; imuno-histoquímica

Tumours of central nervous system (CNS) represent the second most frequent malignancy in children under 15 years of age but are the commonest cause of death. The authors present the epidemiologic and histopathologic analysis of 623 primary tumours of CNS occurring during the period 1990 to 1996 in paediatric patients. In this period 3318 biopsies of CNS were analyzed. In this total were included 623 paediatric tumours (18.7%). The age of patients ranged from 5 months to 15 years, 325 tumours occurred in males and 298 in females. The majority affected the posterior fossa. The majority of paediatric neoplasias were of glial origin (n=277). The most frequent tumours were: astrocytoma (27.9%), medulloblastoma (9.95%), craniopharyngioma (5.93%), ependymoma (4.97%) and glioblastoma (3.37%).

brain tumours; infancy; central nervous system; immunohistochemistry

Tumores pediátricos primários do sistema nervoso central: Estudo anatomopatológico de 623 casos

Primary paediatric tumours of the central nervous system: pathological study of 623 cases

Luiz Fernando Bleggi Torres^I; Graciela Vanessa Vicelli Jacob^II; Jorge Sérgio Reis-Filho^II; Lúcia de Noronha^III

^ISeção de Microscopia Eletrônica e Neuropatologia do Serviço de Anatomia Patológica do Hospital de Clínicas da Universidade Federal do Paraná (HC/UFPR), Curitiba: Professor Adjunto e Chefe do Serviço de Anatomia Patológica do HC/UFPR

^IISeção de Microscopia Eletrônica e Neuropatologia do Serviço de Anatomia Patológica do Hospital de Clínicas da Universidade Federal do Paraná (HC/UFPR), Curitiba: Estagiário da Seção de Microscopia Eletrônica e Neuropatologia do Serviço de Anatomia Patológica do HC/UFPR

^IIISeção de Microscopia Eletrônica e Neuropatologia do Serviço de Anatomia Patológica do Hospital de Clínicas da Universidade Federal do Paraná (HC/UFPR), Curitiba: Médica do Serviço de Anatomia Patológica e Mestranda em Medicina Interna HC/UFPR

RESUMO

Tumores primários do sistema nervoso central (SNC) representam a segunda mais freqüente forma de neoplasia em crianças abaixo dos 15 anos, entretanto são as principais neoplasias responsáveis pelo óbito. Os autores relatam a análise epidemiológica e histopatológica de 623 tumores primários do SNC que acometeram pacientes pediátricos no período de 1990 a 1996 na cidade de Curitiba- PR. Neste período foram analisadas 3318 biópsias de SNC. Do total, 623 eram provenientes de neoplasias acometendo pacientes pediátricos (18,7%). As idades dos pacientes variaram de S meses a 15 anos, sendo que 325 tumores ocorreram no sexo masculino e 298 no sexo feminino. Grande parte dos tumores localizava-se na fossa posterior. Dos 623 tumores, 277 eram de origem glial. As mais freqüentes foram: astrocitoma (27,9%), meduloblastoma (9,95%), craniofaringioma (5,93%), ependimoma (4,97%) e glioblastoma (3,37%).

Palavras-chave: tumores cerebrais, infância, sistema nervoso central, imuno-histoquímica.

ABSTRACT

Tumours of central nervous system (CNS) represent the second most frequent malignancy in children under 15 years of age but are the commonest cause of death. The authors present the epidemiologic and histopathologic analysis of 623 primary tumours of CNS occurring during the period 1990 to 1996 in paediatric patients. In this period 3318 biopsies of CNS were analyzed. In this total were included 623 paediatric tumours (18.7%). The age of patients ranged from 5 months to 15 years, 325 tumours occurred in males and 298 in females. The majority affected the posterior fossa. The majority of paediatric neoplasias were of glial origin (n=277). The most frequent tumours were: astrocytoma (27.9%), medulloblastoma (9.95%), craniopharyngioma (5.93%), ependymoma (4.97%) and glioblastoma (3.37%).

Key words: brain tumours, infancy, central nervous system, immunohistochemistry.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Aceite: 16-agosto-1997.

Dr. Luiz Fernando Bleggi Torres, M.D., Ph.D - Seção de Microscopia Eletrônica e Neuropatologia, Serviço de Anatomia Patológica - Hospital de Clínicas UFPR - Rua General Carneiro 181 - 80060-900 Curitiba PR - Brasil. FAX 041 264 2513.

1. Bancroft JD, Stevens A. Theory and practice of histological techniques. Ed 2. New York: Churchill Livingstone, 1982.
2. Honing PJ, Charney EB. Children with brain tumor headaches. Am J Dis Child 1982;136:121-124.
3. Lauressen TC, Siegel KR, Packer RJ, et al. Long prodromal presentation of pediatric brain tumors. Abstract. Proc Am Assn Neurol Surg (Sect Ped Neurol) 1984.
4. Lesser GJ, Grossman S. The chemotherapy of hight-grade astrocytomas. Semin Oncol 1994;21:220-235.
5. Livesey EA, Hindmash PC, Brook CGD, et al. Endocrine disorders following treatment of chilhood brain tumours. Br J Cancer 1990;61:622-625.
6. Marchese MJ, Chang CH. Malignant astrocytic gliomas in children. Cancer 1990;65:2771-2778.
7. Mostow EN, Byrne J, Connelly RR, Mulvihill JJ. Quality of life in long-term survivors of CNS tumours in childhood and adolescence. J Clin Oncol 1991;9:592-599.
8. Nishio SH, Takeshita I, Fuji I, Fukui M. Supratentorial astrocytic tumours of childhood: a clinicopathologic study of 41 cases. Acta Neurochir (Wien) 1989;101:3-8.
9. Packer RJ, Sutton LN, Atkins TE, et al. A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemoterapy: 2-year results. J Neurosurg 1989;70:107-173.
10. Packer RJ, Vezina G. Pediatric glial neoplasms including brain-stem gliomas. Semin Oncol 1994;21:260-272.
11. Preston-Martin S, Navidi W, Thomas D, Lee PJ, Pogoda J. Los Angeles study of residential magnetic fields and childhood brain tumors. Am J Epidemiol 1996;143:105-119.
12. Schiff D, Wen PY. Uncommon brain tumors. Neurol Clin 1995;13:953-975.
13. Schofield DE. Diagnostic histopathology, cytogenetics and molecular markers of pediatric brain tumors. Neurosurg Clin North Am 1992;3:723-738.
14. Schwartz RB. Neuroradiology of brain tumors. Neurol Clin 1995;13:723- 753.
15. Segall MD, Batnizky S, Zee CS, et al. Computed tomography in the diagnosis of intracranial neoplasm in children. Cancer 1985;56:1748-1755.
16. Shiminski-Maher T, Shields M. Pediatric brain tumors: diagnosis and management. J Pediatr Oncol Nurs (United States) 1995;12:188-198.
17. Torres LFB, Almeida R, Ávila S, Alessi S, Freitas R. Brain tumours in South Brazil: a retrospective study of 438 cases. Arq Neuropsiquiatr 1990;48(3):279-285.
18. Torres LFB, Noronha L, Telles JEQ. A importância da imunohistoqüímica no diagnóstico anátomo-patológico em hospital geral: análise de 885 casos. J Bras Patol 1995;31:65-71.

Datas de Publicação

Publicação nesta coleção
21 Out 2010
Data do Fascículo
1997

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. Bancroft JD, Stevens A. Theory and practice of histological techniques. Ed 2. New York: Churchill Livingstone, 1982.

[2] 2. Honing PJ, Charney EB. Children with brain tumor headaches. Am J Dis Child 1982;136:121-124.

[3] 3. Lauressen TC, Siegel KR, Packer RJ, et al. Long prodromal presentation of pediatric brain tumors. Abstract. Proc Am Assn Neurol Surg (Sect Ped Neurol) 1984.

[4] 4. Lesser GJ, Grossman S. The chemotherapy of hight-grade astrocytomas. Semin Oncol 1994;21:220-235.

[5] 5. Livesey EA, Hindmash PC, Brook CGD, et al. Endocrine disorders following treatment of chilhood brain tumours. Br J Cancer 1990;61:622-625.

[6] 6. Marchese MJ, Chang CH. Malignant astrocytic gliomas in children. Cancer 1990;65:2771-2778.

[7] 7. Mostow EN, Byrne J, Connelly RR, Mulvihill JJ. Quality of life in long-term survivors of CNS tumours in childhood and adolescence. J Clin Oncol 1991;9:592-599.

[8] 8. Nishio SH, Takeshita I, Fuji I, Fukui M. Supratentorial astrocytic tumours of childhood: a clinicopathologic study of 41 cases. Acta Neurochir (Wien) 1989;101:3-8.

[9] 9. Packer RJ, Sutton LN, Atkins TE, et al. A prospective study of cognitive function in children receiving whole-brain radiotherapy and chemoterapy: 2-year results. J Neurosurg 1989;70:107-173.

[10] 10. Packer RJ, Vezina G. Pediatric glial neoplasms including brain-stem gliomas. Semin Oncol 1994;21:260-272.

[11] 11. Preston-Martin S, Navidi W, Thomas D, Lee PJ, Pogoda J. Los Angeles study of residential magnetic fields and childhood brain tumors. Am J Epidemiol 1996;143:105-119.

[12] 12. Schiff D, Wen PY. Uncommon brain tumors. Neurol Clin 1995;13:953-975.

[13] 13. Schofield DE. Diagnostic histopathology, cytogenetics and molecular markers of pediatric brain tumors. Neurosurg Clin North Am 1992;3:723-738.

[14] 14. Schwartz RB. Neuroradiology of brain tumors. Neurol Clin 1995;13:723- 753.

[15] 15. Segall MD, Batnizky S, Zee CS, et al. Computed tomography in the diagnosis of intracranial neoplasm in children. Cancer 1985;56:1748-1755.

[16] 16. Shiminski-Maher T, Shields M. Pediatric brain tumors: diagnosis and management. J Pediatr Oncol Nurs (United States) 1995;12:188-198.

[17] 17. Torres LFB, Almeida R, Ávila S, Alessi S, Freitas R. Brain tumours in South Brazil: a retrospective study of 438 cases. Arq Neuropsiquiatr 1990;48(3):279-285.

[18] 18. Torres LFB, Noronha L, Telles JEQ. A importância da imunohistoqüímica no diagnóstico anátomo-patológico em hospital geral: análise de 885 casos. J Bras Patol 1995;31:65-71.