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Arq. Neuro-Psiquiatr. vol.67 no.1 São Paulo Mar. 2009
VIEWS AND REVIEWS
HTLV-1 and neurological conditions: when to suspect and when to order a diagnostic test for HTLV-1 infection?
Doenças neurológicas e infecção pelo HTLV-1: quando suspeitar e quando solicitar testes diagnósticos para a infecção pelo HTLV-1
Abelardo Q.C. Araújo; Ana Claudia C. Leite; Marco Antonio S.D. Lima; Marcus Tulius T. Silva
Laboratory of Clinical Research in Neuroinfections, Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ)
HTLV-1 is a retrovirus associated with a myriad of clinical conditions, especially hematological and neurological ones. Regarding nervous system diseases, it is of utmost importance to select those cases in which HTLV-1 infection could really be associated. This is particularly true for patients from endemic areas and for HIV-infected patients and drug users, since that these groups are at a higher risk for HTLV infection. This caution in selecting neurological patients for HTLV diagnostic tests is justified by the fact that in some circumstances the seropositivity may merely represent an epiphenomenon. In this paper we enroll some neurological conditions that have been associated with HTLV-1/2 infection in the literature and discuss the real need for HTLV-1/2 diagnostic tests in each one. Because HIV/HTLV-co-infected patients seem to be at an increased risk for neurological diseases development, a special consideration about this matter is also made.
Key words: HTLV, myelopathy, myopathy, peripheral neuropathy, HIV.
O HTLV-1 é um retrovírus associado tanto a doenças hematológicas quanto a doenças neurológicas. Em relação às doenças neurológicas, é fundamental que selecionemos aquelas em que de fato a infecção pelo HTLV-1 possa ser a causa. Isto é particularmente verdadeiro nos pacientes oriundos de áreas endêmicas e nos pacientes infectados pelo HIV e usuários de drogas, haja vista que estes grupos são de risco para infecção pelo HTLV. Este cuidado ao selecionarmos aquelas condições neurológicas que merecem ser investigadas com sorologia para o HTLV se justifica pelo fato de que nem sempre podemos afastar uma associação fortuita entre a infecção e a referida doença. Neste artigo, comentaremos sobre algumas condições neurológicas que podem estar associadas com a infecção pelo HTLV-1/2, discutindo a real necessidade de solicitar testes para o diagnóstico da infecção pelo HTLV-1/2 frente a elas. Uma breve consideração sobre a co-infecção HIV/HTLV será feita no final deste artigo tendo em vista que estes pacientes apresentam um risco aumentado para o desenvolvimento de doenças neurológicas.
Palavras-chave: HTLV, mielopatia, miopatia, neuropatia periférica, HIV.
The human T cell lymphotropic virus type 1 (HTLV-1) is a retrovirus and the etiologic agent of both a group of hematological disorders known as Adult T cell leukemia/lymphoma (ATLL)1 and a group of neurological conditions known altogether as the HTLV-1 neurological complex2, of which the most common is the HTLV-1 associated myelopathy/Tropical spastic paraparesis (HAM/TSP)3. Endemic infection with HTLV-1 is now recognized to be worldwide, and is also common in Brazil4. The number of people around the world infected with HTLV-1 is estimated as being between 10 to 20 million. There are areas in Japan, sub-Saharan Africa, the Caribbean, and South America where more than 1% of the general population is infected. The overall HTLV-1 seroprevalence among blood donors in Brazil is approximately 0.45%. However, these rates vary, from 0 to 1.8%, depending on the region5.
Although the majority of HTLV-1 carriers remain asymptomatic for the rest of their lives, the cumulative lifetime risk of developing ATLL or HAM/TSP is around 5%6. HTLV-1 can be transmitted from mother to child, during sexual intercourse, and through contaminated blood products7. HTLV-1 has a special tropism for CD4+ lymphocytes and uses GLUT-1, the ubiquitous vertebrate glucose transporter, as the main receptor to infect cells8. It is transmitted from cell to cell through a viral synapse and enters target cells via interaction with GLUT-1 in association with Neuropilin-1 (NRP1), the receptor for semaphorin-3A, and VEGF-A165, a member of the immune synapse. GLUT1, NRP1, and the HTLV-1 envelope protein form ternary complexes in transfected cells9.
The diagnosis of HTLV-1 infection can be made either by serological tests (ELISA and Western Blot [WB], Immunofluorescence, Particle Agglutination), by detection of the HTLV-1 genome (Polymerase Chain Reaction - PCR) or by virus isolation. The sensitivity for diagnosis of HTLV-1 is higher with ELISA than with WB10. Some serologic tests yield high rates of false-positive results. Therefore, a few authors believe that PCR can be more sensitive than serology for this diagnosis. PCR should therefore be considered for selected HTLV-I antibody-negative patients with unexplained spastic myelopathy or T-cell neoplasia11. Although a positive ELISA requires a further confirmation by WB, this test still gives a high percentage of indeterminate results10. In the cerebrospinal fluid (CSF) diagnosis can be made either by ELISA/WB alone or by a combination of PCR in the CSF and the intrathecal synthesis of antibodies to HTLV-1 by the antibody index (AI). Cases of HAM/TSP may have increased AI for HTLV-1 and the presence of HTLV-1 proviral sequences in CSF by PCR12.
The present review aims to provide neurologists with data that can assist them to choose those clinical neurological circumstances that could be most probably due to HTLV-1 infection. In these instances, HTLV-1 testing should be ordered to clarify the diagnosis.
ACUTE DISSEMINATED ENCEPHALOMYELITIS
Generally speaking, acute disseminated encephalomyelitis (ADEM) is a monophasic demyelinating disease of the central nervous system that commonly follows immunization or infections. Several pathogens have been implicated in this condition such as enteroviruses, herpes simplex viruses, hepatitis A virus, Epstein Barr virus, influenza, measles, mycoplasma, rubella, and varicella zoster. There are only a few reports of ADEM in HTLV-I infected patients13 and it is not clear if the virus is directly implicated in the demyelinating process or if HTLV infection is only a epiphenomenon. So, to date there is no hard evidence for proposing routine HTLV-1 tests in ADEM patients.
ENCEPHALOPATHY AND COGNITIVE DEFICITS
The first reports of brain MRI lesions in HAM/TSP patients appeared shortly after the initial HAM/TSP descriptions14. The prevalence of these lesions is said to be around 50% to 80%, suggesting that the inflammatory response against HTLV-1 may not be restricted to the spinal cord15.
The interest for cognitive disturbances in HTLV-1 infection started after a number of reports describing these brain MRI abnormalities in patients with HAM/TSP. Because the white matter lesions of HAM/TSP are somehow similar to those observed in patients with multiple sclerosis or in HIV infected people (both conditions with well known cognitive impairment), cognitive deficits in HAM/TSP patients were also suspected. Most of the published papers about cognitive disturbances in HAM/TSP describe psychomotor slowing, attention deficits as well as visual and working memory deficits16,17. In the only controlled study using an extensive neuropsychological battery, HTLV-1 infection was associated with mild cognitive deficits characterized by impairments in psychomotor speed, verbal fluency, verbal and visual memory, selective and alternate attention (flexibility), and visuoconstructive abilities18.
We suggest that in endemic areas HTLV-1 testing should be performed in patients with myelopathic symptoms and signs, brain white matter abnormalities on MRI, and mild, subcortical cognitive deficits.
Subacute meningitis can be rarely seen in patients with HTLV-I infection19-23. Most patients presented a decreased level of consciousness and a stiff neck. The proposed mechanism is meningeal lymphomatous infiltration, similar to that found in ATLL. Hence, HTLV-I testing should be considered in patients with subacute meningitis with mononuclear predominance in areas with a high prevalence of HTLV-I infection, particularly in those individuals with leukemia or lymphoma.
ACUTE SPASTIC PARAPARESIS
HAM/TSP is classically described as a chronic myelopathy with insidious onset and a slow evolution over years. Nevertheless, patients with acute or subacute evolution over days to weeks have been described24-28. The prevalence of subacute evolution was estimated in 7.9% in a reference center for HTLV in Rio de Janeiro, Brazil28. The factors related to such aggressive course are not completely understood, but recently we have demonstrated that patients with subacute evolution have HTLV-1 proviral load quantification similar to patients with typical evolution28. We believe that patients with acute, non-compressive myelitis should be tested for HTLV-1, especially if tests for other causes are inconclusive.
PROGRESSIVE SPASTIC PARAPARESIS
HTLV-1 is the main cause of chronic progressive spastic paraparesis in Brazil5. The first Brazilian nationwide study on the disease concluded that (1) HAM/TSP was more prevalent among women and whites, (2) the most important risk factors for infection were sexual promiscuity and blood transfusion, and (3) although a remarkably uniform disease throughout the country is observed, some statistically significant differences were detected such as a higher proportion of females over males in the Northeast region, a higher proportion of whites in the Southeast and in the South while in the Northeast infection predominates in the mulattos, and a high rate of venereal diseases in the Southeast region and of intravenous drug use in the South29.
The typical patient in whom a search for HTLV-1 infection should be sought is the one with a slowly progressive and non-compressive paraparesis in the lower limbs, widespread pyramidal signs (i.e., in upper and lower limbs), urinary urgency or incontinence, constipation, and subtle objective sensory signs (mainly decreased vibration sense)30. A clear-cut sensory level may occur but is exceedingly rare3. Some patients complain of lumbar pain, sometimes with radicular radiation down to the legs. This pain, which occasionally can be very disabling, has a combination of neuropathic and mechanical features31. For a more detailed account of clinical features and diagnostic guidelines for HAM/TSP the reader is referred to other sources2,32 .
CONUS MEDULLARIS SYNDROME
Conus medullaris lesions lead to early sphincter disturbances (flaccid bladder, constipation), impotence, and saddle anesthesia with mild motor disturbances. Common causes include disc herniation, tumors, and fractures at L2 level. In HAM/TSP patients, thoracic spinal cord is the most affected site by the inflammatory process33 and a complete conus medullaris syndrome is not usually seen in these patients. However, patients may present with bowel or bladder symptoms as first manifestations of HAM/TSP in the absence of motor complaints, which can sometimes suggest involvement of the conus34,35. Thus, we recommend HTLV-1 testing in patients with conus medullaris syndrome and no apparent lesion on the lumbar spine MRI.
AMYOTROPHIC LATERAL SCLEROSIS (ALS) SYNDROME
ALS syndrome in HTLV-1 infection has been described since 1991, but in some cases an epiphenomenon cannot be excluded36. Typically, HTLV-1-infected patients with symptoms and signs suggestive of ALS have a high HTLV proviral load and present symptoms and sings suggestive of HAM/TSP jointly with symptoms and signs typical of ALS, i.e. muscle atrophy, fasciculation, and cramps. In general, these patients tend to evolve more slowly than typical, non-infected ALS patients37,38. Thus, we suggest that patients from endemic areas with symptoms and signs suggestive of both upper and lower motor neuron disorder jointly with sensory symptoms and/or bladder dysfunction should be routinely tested for HTLV antibodies.
Although the most frequent site of nervous system lesion in the HTLV-1 infection is the thoracic spinal cord, which leads to the development of HAM/TSP, the virus may affect all components of the neuroaxis, including muscles. Muscle damage is not related to direct invasion of muscle fibers by the virus, but to an immune-mediated process39. Classically, both polymyositis (PM)40 and inclusion body myositis (IBM)41 have been associated with HTLV-1 infection. Furthermore, clinicians may also consider ordering HTLV-1 testing in the context of isolated cramps without other features of myopathy and in patients with persistent serum creatine phosphokinase (CK) elevation.
The clinical presentation of HTLV-1-related PM is similar to that of idiopathic PM. Symmetrical and proximal weakness and varying degrees of myalgia are usually seen early in the disease. Bulbar muscles are clinically affected in one third of the cases. Deep tendon reflexes are diminished or abolished but may be normal or even brisk in patients with concomitant HAM/TSP. Other manifestations such as rheumatologic (arthritis, Raynaud's phenomenon), cardiac (myocarditis), and respiratory (pneumonitis) complications are present in HTLV-1-related PM, but they are less frequent than in HTLV-I-seronegative PM40,41.
IBM occurs predominantly in males over 50 years of age. Onset is insidious and slowly progressive, which can delay diagnosis. Proximal and distal muscles are affected asymetrically. Quadriceps, volar, and ankle dorsiflexors muscles are affected early. Extraocular muscles tend to be spared. One third of patients have a mild sensory neuropathy. CK levels are minimally elevated or normal in most affected individuals41.
Persistent cramps may be found in several metabolic, genetic, and inflammatory myopathies. Occasionally, isolated muscle cramps are the first sign of HAM/TSP and may be present years before the development of overt myelopathy. Though there is no hard evidence, clinicians may consider ordering HTLV-I testing in patients with muscle cramps from endemic areas after exclusion of other etiologies.
Persistently increased serum CK levels usually reflect the presence of neuromuscular disease42. Chronic elevation of serum CK is occasionally encountered in apparently healthy individuals with no evidence of muscle disease on clinical and laboratory evaluation. In large series of patients with CK elevation, HTLV-1 infection was not observed in none of the patients, but these studies came from areas with a low prevalence of HTLV-1 infection. Glynn et al. have demonstrated higher serum CK levels in HTLV-1/2 infected blood donors when compared with non-infected individuals43. CK elevation in HTLV-1 carriers is usually associated with clinical evidence of myopathy, but in a setting of endemic infection is reasonable to consider HTLV-1 testing in individuals with persistent serum CK elevation.
In summary, while there is large evidence for advice HTLV-1 testing in patients with PM and IBM, one may consider investigation in individuals with persistent cramps or serum CK elevation in areas with high prevalence of HTLV-1 infection.
PERIPHERAL NERVOUS SYSTEM DISEASES
The reported prevalence of peripheral neuropathy (PN) in HTLV-1 infection has varied from negligible to 32%44,45. Majority of cases are presently seen in association with HAM/TSP, but isolated PN has been reported46. Furthermore, a higher prevalence of PN in HIV/HTLV-2 co-infection was described, suggesting that HTLV-2 could be a predisposing cofactor for development of PN in HIV-infected patients. Since HTLV-1 and HTLV-2 share genetic homology the same could be expected in HIV/HTLV-1 co-infection47.
At present there is no evidence of direct viral infection of the peripheral nervous system. In addition, previous studies demonstrated that spinal nerve roots are also involved in the inflammatory process that causes HAM/TSP48. Therefore, either a proximal or a distal inflammatory mechanism may be responsible for PN associated with HAM/TSP. Lymphocytic infiltrates have been observed in both spinal cord and muscle tissues in patients with HTLV-I-associated polymyositis. Axonal atrophy demyelination, remyelination, and perineural fibrosis in sural nerve biopsy specimens from HAM/TSP patients with PN has been reported49. More recently, Kiwai et al. described 9 biopsy-proven cases of PN in association with TSP/HAM48. Sural nerve pathology of these individuals revealed a combination of demyelination and remyelination, and axonal degeneration and regeneration. They also failed to demonstrate inflammatory infiltrates in these samples.
PN associated with HTLV-1 is characterized by paresthesiae, burning sensations, and abnormal superficial sensation distally in a stock-and-glove distribution, coupled with abolished ankle jerks. Cases of acute or chronic polyradiculoneuropathy and chronic sensory neuropathy presenting as severe impairment of proprioceptive and kinesthetic sensation associated with HTLV-1 have been described, but there is uncertainty about the role of the infection in the pathogenesis of these neurological conditions.
In summary, according to the aforementioned evidences we strongly suggest that patients from endemic areas with PN symptoms or signs should be routinely investigated for HTLV-1 infection.
Even in HTLV endemic areas there are no sufficient data to advice a routinely HTLV antibodies tests in isolated cranial neuropathies. Although a few reports have showed peripheral facial palsy in HTLV infected patients, an epiphenomenon could not be excluded50,51. The only exception seems to be a simultaneous involvement of optic nerve and spinal cord such as the one observed in Devic's disease52. In this situation we recommend HTLV-1/2 antibodies testing (ELISA/WB) both in serum and in CSF.
Although some extrapiramidal syndromes such as Parkinsonism, essential tremor, and myoclonus have been described in a few infected patients, a causal relationship between HTLV infection and these movement disorders is presently obscure53,54. So, even in endemic areas HTLV antibodies tests would not be necessarily done in patients with movement disorders and lack of evidence of other neurological abnormality definitely associated with HTLV-1/2.
There are strong evidences supporting autonomic dysfunction in HTLV-1/2 infection. Reports have showed orthostatic hypotension, lack of sweat control, and neurogenic bladder dysfunction, the majority of them in association with HAM/TSP55-59. Neurogenic bladder dysfunction has also been showed in HTLV-1-infected patients without HAM/TSP34 . So, in endemic areas we advice HTLV-1 antibodies tests in patients exhibiting autonomic dysfunction of unknown cause.
MULTIPLE SCLEROSIS PATIENTS
To rule out HTLV-1 infection is mandatory in any patient with symptoms and signs suggestive of multiple sclerosis (MS). The question here is if the clinical picture is due to MS or due to HAM/TSP in an HTLV-1-infected patient. This differentiation is quite difficult especially if we consider the myelopathic, primary progressive form of MS60. Maybe in these patients HTLV-1 proviral load measurements could be useful, since HAM/TSP patients exhibit higher level of proviral loads than MS patients seropositive to HTLV-161.
In addition to the fact that HTLV and HIV share a common tropism for T cells and exhibit similarity on modes of transmission, both have the potential to affect the nervous system. However, HTLV-1 is cell proliferative, poorly replicative, and genetically stable, whereas HIV-1 has the opposite behaviour62.
Since the beginning of the HIV epidemic, neurological disorders have been reported as very frequent and disabling among AIDS patients63. For example, the nervous system is affected in 26% to 94% of HIV-infected individuals in Brazil64. As a result, since both HTLV and HIV are associated with neurological disorders, there is a reasonable concern about an increased risk of neurological diseases among HIV/HTLV-coinfected individuals.
Regarding neurologic diseases in coinfected individuals, there are some papers pointing to a higher prevalence of myelopathy in coinfected individuals when compared to monoinfected HIV patients. In 9 coinfected individuals authors described 2 HIV/HTLV-1 and one HIV/HTLV-2-coinfected patients with a slowly progressive myelopathy resembling HAM/TSP65. In other transversal study, 73% of 15 coinfected subjects had evidences of myelopathy versus 16% of 62 HIV monoinfected individuals (OR=13.0)66. Peripheral neuropathy was also more prevalent among coinfected than monoinfected individuals. More recently, in a large cohort (62 HIV/HTLV-1 and 141 HIV/HTLV-2 coinfected patients) followed for many years, Beilke et al. verified that coinfected patients were more likely to presented neurologic complications than HIV-infected individuals, mainly peripheral neuropathy67. Similar results were reported by Zehender et al. who studied 30 HTLV-2/HIV-coinfected patients for 28 months. They reported an increased risk of developing peripheral neuropathy (OR 3.3), and during the period of observation one coinfected patient developed myelopathy.
So, since that both HIV and HTLV share similar infection routes and are prone to cause neurological diseases, HTLV antibodies should be investigated in every HIV infected patient and vice-versa.
Table summarizes the main conditions in which HTLV testing should be sought. HTLV-1/2 infection is associated with a variety of neurological disorders and can confuse a precise clinical judgment in some circumstances, particularly in MS patients and in patients with non-compressive chronic spastic paraparesis. Also, co-infection with HIV can increase the risk for neurological disease, namely myelopathy and peripheral neuropathy. Therefore, it is important for the neurologist to be aware of those neurological conditions in which HTLV-1/2 antibodies tests should be included in the neurological investigation, particularly in endemic regions.
1. Takatsuki K. Kenneth MacGredie Memorial Lectureship. Adult T-cell leukemia/lymphoma. Leukemia 1997;11(Suppl 3):S54-S6. [ Links ]
2. Araujo AQ, Silva MT. The HTLV-1 neurological complex. Lancet Neurol 2006;5:1068-1076. [ Links ]
3. Araujo AQ, Alfonso CR, Schor D, Leite AC, Andrada-Serpa MJ. Clinical and demographic features of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) in Rio de Janeiro, Brazil. Acta Neurol Scand 1993;88:59-62. [ Links ]
4. Carneiro-Proietti AB, Ribas JG, Catalan-Soares BC, et al. [Infection and disease caused by the human T cell lymphotropic viruses type I and II in Brazil]. Rev Soc Bras Med Trop 2002;35:499-508. [ Links ]
5. Araujo AQ, Andrada-Serpa MJ. Tropical spastic paraparesis/HTLV-I-associated myelopathy in Brazil. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13(Suppl 1):S33-S37. [ Links ]
6. de The G, Bomford R. An HTLV-I vaccine: why, how, for whom? AIDS Res Hum Retroviruses 1993;9:381-386. [ Links ]
7. Verdonck K, Gonzalez E, Van Dooren S, Vandamme AM, Vanham G, Gotuzzo E. Human T-lymphotropic virus 1: recent knowledge about an ancient infection. Lancet Infect Dis 2007;7:266-281. [ Links ]
8. Jin Q, Agrawal L, VanHorn-Ali Z, Alkhatib G. Infection of CD4+ T lymphocytes by the human T cell leukemia virus type 1 is mediated by the glucose transporter GLUT-1: evidence using antibodies specific to the receptor's large extracellular domain. Virology 2006;349:184-196. [ Links ]
9. Ghez D, Lepelletier Y, Lambert S, et al. Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry. J Virol 2006;80:6844-6854. [ Links ]
10. Thorstensson R, Albert J, Andersson S. Strategies for diagnosis of HTLV-I and -II. Transfusion 2002;42:780-791. [ Links ]
11. van der Ryst E, Smith MS, Visagie HM. Comparison of the polymerase chain reaction and serology for the diagnosis of HTLV-I infection. J Infect 1996;32:109-112. [ Links ]
12. Puccioni-Sohler M, Rios M, Carvalho SM, et al. Diagnosis of HAM/TSP based on CSF proviral HTLV-I DNA and HTLV-I antibody index. Neurology 2001;57:725-727. [ Links ]
13. Tachi N, Watanabe T, Wakai S, Sato T, Chiba S. Acute disseminated encephalomyelitis following HTLV-I associated myelopathy. J Neurol Sci 1992;110:234-235. [ Links ]
14. Tournier-Lasserve E, Gout O, Gessain A, et al. HTLV-I, brain abnormalities on magnetic resonance imaging, and relation with multiple sclerosis. Lancet 1987;2:49-50. [ Links ]
15. Kira J, Fujihara K, Itoyama Y, Goto I, Hasuo K. Leukoencephalopathy in HTLV-I-associated myelopathy/tropical spastic paraparesis: MRI analysis and a two year follow-up study after corticosteroid therapy. J Neurol Sci 1991;106:41-49. [ Links ]
16. Cartier L, Gormaz A. [Subcortical dementia in HTLV-I tropical spastic paraparesis. Study of 43 cases]. Rev Med Chil 1999;127:444-450. [ Links ]
17. Fukushima T, Ikeda T, Uyama E, Uchino M, Okabe H, Ando M. Cognitive event-related potentials and brain magnetic resonance imaging in HTLV-1 associated myelopathy (HAM). J Neurol Sci 1994;126:30-39. [ Links ]
18. Silva MT, Mattos P, Alfano A, Araujo AQ. Neuropsychological assessment in HTLV-1 infection: a comparative study among TSP/HAM, asymptomatic carriers, and healthy controls. J Neurol Neurosurg Psychiatry 2003;74:1085-1089. [ Links ]
19. Yokota T, Yamada M, Furukawa T, Tsukagoshi H. HTLV-I-associated meningitis. J Neurol 1988;235:129-130. [ Links ]
20. Araga S, Takahashi K, Ooi S. Subacute meningoencephalitis associated with human T-lymphotrophic virus type I (HTLV-I): report of a case. Acta Neurol Scand 1989;79:361-365. [ Links ]
21. Gomes I, Nascimento MH, Moreno-Carvalho OA, Melo A. Lymphomatous meningoencephalitis in a patient with HAM/TSP. Arq Neuropsiquiatr 1995;53:123-125. [ Links ]
22. Kawano Y, Kira J. Chronic hypertrophic cranial pachymeningitis associated with HTLV-I infection. J Neurol Neurosurg Psychiatry 1995;59: 435-437. [ Links ]
23. Kasahata N, Kawamura M, Shiota J, Miyazawa Y, Suzuki Y, Sugita K. [A case of acute type adult T cell leukemia and human T-lymphotropic virus type I associated myelopathy who presented meningitis and polyradiculoneuropathy and improved with steroid treatment]. No To Shinkei 2000;52:1003-1006. [ Links ]
24. Yoshida Y, Machigashira N, Wang SY, Osame M. A patient with acute-onset HAM/TSP after blood transfusion complicated with pseudopseudohypoparathyroidism. Intern Med 2002;41:899-900. [ Links ]
25. Shakudo M, Inoue Y, Tsutada T. HTLV-I-associated myelopathy: acute progression and atypical MR findings. AJNR Am J Neuroradiol 1999;20: 1417-1421. [ Links ]
26. Nakagawa M, Izumo S, Ijichi S, et al. HTLV-I-associated myelopathy: analysis of 213 patients based on clinical features and laboratory findings. J Neurovirol 1995;1:50-61. [ Links ]
27. Sato Y, Honda Y, Ohshima Y, Honda E, Oizumi K, Takeuchi N. Acute myelopathy and cerebellar signs associated with uveitis with positive serum and cerebrospinal fluid antibodies to HTLV-I. Kurume Med J 1994;41:193-197. [ Links ]
28. Lima MA, Harab RC, Schor D, Andrada-Serpa MJ, Araujo AQ. Subacute progression of human T-lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis. J Neurovirol 2007;13:468-473. [ Links ]
29. Araujo AQ, Andrade-Filho AS, Castro-Costa CM, Menna-Barreto M, Almeida SM. HTLV-I-associated myelopathy/tropical spastic paraparesis in Brazil: a nationwide survey. HAM/TSP Brazilian Study Group. J Acquir Immune Defic Syndr Hum Retrovirol 1998;19:536-541. [ Links ]
30. Araujo AC, Afonso CR, Schor D, Andrada-Serpa MJ. Spastic paraparesis of obscure origin. A case-control study of HTLV-I positive and negative patients from Rio de Janeiro, Brazil. J Neurol Sci 1993;116:165-169. [ Links ]
31. Franzoi AC, Araujo AQ. Disability profile of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis using the Functional Independence Measure (FIM). Spinal Cord 2005;43:236-240. [ Links ]
32. Castro-Costa CM, Araujo AQ, Barreto MM, et al. Proposal for diagnostic criteria of tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). AIDS Res Hum Retroviruses 2006;22:931-935. [ Links ]
33. Iwasaki Y. Pathology of chronic myelopathy associated with HTLV-I infection (HAM/TSP). J Neurol Sci 1990;96:103-123. [ Links ]
34. Silva MT, Coutinho F, Leite AC, Harab RC, Araújo A, Andrada-Serpa MJ. Isolated bladder dysfunction in Human T Lymphotropic Virus type 1 infection. Clin Infect Dis 2008; in press. [ Links ]
35. Walton GW, Kaplan SA. Urinary dysfunction in tropical spastic paraparesis: preliminary urodynamic survey. J Urol 1993;150:930-932. [ Links ]
36. Kuroda Y, Sugihara H. Autopsy report of HTLV-I-associated myelopathy presenting with ALS-like manifestations. J Neurol Sci 1991;106:199-205. [ Links ]
37. Silva MT, Leite AC, Alamy AH, Chimelli L, Andrada-Serpa MJ, Araujo AQ. ALS syndrome in HTLV-I infection. Neurology 2005;65:1332-1333. [ Links ]
38. Matsuzaki T, Nakagawa M, Nagai M, et al. HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP) with amyotrophic lateral sclerosis-like manifestations. J Neurovirol 2000;6:544-548. [ Links ]
39. Ozden S, Cochet M, Mikol J, Teixeira A, Gessain A, Pique C. Direct evidence for a chronic CD8+-T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositis. J Virol 2004;78: 10320-10327. [ Links ]
40. Gilbert DT, Morgan O, Smikle MF, Simeon D, Barton EN. HTLV-1 associated polymyositis in Jamaica. Acta Neurol Scand 2001;104:101-104. [ Links ]
41. Dalakas MC. Inflammatory, immune, and viral aspects of inclusion-body myositis. Neurology 2006;66(Suppl 1):S33-S38. [ Links ]
42. Walker RH, Jung HH, Danek A. Diagnostic evaluation of clinically normal subjects with chronic hyperCKemia. Neurology 2007;68:535. [ Links ]
43. Glynn SA, Murphy EL, Wright DJ, Sacher RA, Fridey J, Schreiber GB. Laboratory abnormalities in former blood donors seropositive for human T-lymphotropic virus types 1 and 2: a prospective analysis. Arch Pathol Lab Med 2000;124:550-555. [ Links ]
44. Barkhaus PE, Morgan O. Jamaican neuropathy: an electrophysiological study. Muscle Nerve 1988;11:380-385. [ Links ]
45. Roman GC, Roman LN. Tropical spastic paraparesis: a clinical study of 50 patients from Tumaco (Colombia) and review of the worldwide features of the syndrome. J Neurol Sci 1988;87:121-138. [ Links ]
46. Leite AC, Silva MT, Alamy AH, et al. Peripheral neuropathy in HTLV-I infected individuals without tropical spastic paraparesis/HTLV-I-associated myelopathy. J Neurol 2004;251:877-881. [ Links ]
47. Zehender G, De Maddalena C, Osio M, et al. High prevalence of human T cell lymphotropic virus type II infection in patients affected by human immunodeficiency virus type 1--associated predominantly sensory polyneuropathy. J Infect Dis 1995;172:1595-1598. [ Links ]
48. Kiwaki T, Umehara F, Arimura Y, et al. The clinical and pathological features of peripheral neuropathy accompanied with HTLV-I associated myelopathy. J Neurol Sci 2003;206:17-21. [ Links ]
49. Bhigjee AI, Bill PL, Wiley CA, et al. Peripheral nerve lesions in HTLV-I associated myelopathy (HAM/TSP). Muscle Nerve 1993;16:21-26. [ Links ]
50. Deligny C, Cabre P, Thevenot C, Dubreuil F, Arfi S. [Peripheral facial paralysis in a patient infected with HTLV-1 virus. 2 case reports]. Presse Med 2002;31:1746-1747. [ Links ]
51. Bartholomew C, Cleghorn F, Jack N, Edwards J, Blattner W. Human T-cell lymphotropic virus type I-associated facial nerve palsy in Trinidad and Tobago. Ann Neurol 1997;41:806-809. [ Links ]
52. Yoshida Y, Saiga T, Takahashi H, Hara A. Optic neuritis and human T-lymphotropic virus type 1-associated myelopathy: a case report. Ophthalmologica 1998;212:73-76. [ Links ]
53. Puccioni-Sohler M, Papais-Alvarenga R, Souza PM, de Franca SC, Goncalves RR, Jacobson S. Parkinsonism in the course of HTLV-I-associated myelopathy. Mov Disord 2005;20:613-615. [ Links ]
54. Gotuzzo E, Cabrera J, Deza L, et al. Clinical characteristics of patients in peru with human T cell lymphotropic virus type 1-associated tropical spastic paraparesis. Clin Infect Dis 2004;39:939-944. [ Links ]
55. Alamy AH, Menezes FB, Leite AC, Nascimento OM, Araujo AQ. Dysautonomia in human T-cell lymphotrophic virus type I-associated myelopathy/tropical spastic paraparesis. Ann Neurol 2001;50:681-685. [ Links ]
56. Raza SM, Pyatt JR. Nocturnal hypertension and autonomic dysfunction due to human T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Int J Cardiol 2006;107:424-426. [ Links ]
57. Ando Y, Ando E, Vchino M, Ando M. HTLV-1 associated pandysautonomia with adrenal dysfunction. Muscle Nerve 1995;18:928-929. [ Links ]
58. Yokota T, Miura Y, Yamada M, Kaneko K, Miyatake T. Multiple system atrophy with autonomic failure and human T-lymphotrophic virus type I infection. Ann Neurol 1994;35:244. [ Links ]
59. Kano M, Mitsuhata Y, Kishida S, Yano Y, Muro T. Shy-Drager syndrome and human T-lymphotropic virus type I infection. Ann Neurol 1989;25:420-421. [ Links ]
60. Oger J. HTLV-1 infection and the viral etiology of multiple sclerosis. J Neurol Sci 2007;262:100-104. [ Links ]
61. Puccioni-Sohler M, Yamano Y, Rios M, et al. Differentiation of HAM/TSP from patients with multiple sclerosis infected with HTLV-I. Neurology 2007;68:206-213. [ Links ]
62. Prince HE, Jensen ER, York J. Lymphocyte subsets in HTLV-II-infected former blood donors: relationship to spontaneous lymphocyte proliferation. Clin Immunol Immunopathol 1992;65:201-206. [ Links ]
63. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 1988;239:586-592. [ Links ]
64. Silva MT, Araujo A. Highly active antiretroviral therapy access and neurological complications of human immunodeficiency virus infection: impact versus resources in Brazil. J Neurovirol 2005;11(Suppl 3): S11-S15. [ Links ]
65. Berger JR, Svenningsson A, Raffanti S, Resnick L. Tropical spastic paraparesis-like illness occurring in a patient dually infected with HIV-1 and HTLV-II. Neurology 1991;41:85-87. [ Links ]
66. Harrison LH, Vaz B, Taveira DM, et al. Myelopathy among Brazilians coinfected with human T-cell lymphotropic virus type I and HIV. Neurology 1997;48:13-18. [ Links ]
67. Beilke MA, Theall KP, O'Brien M, et al. Clinical outcomes and disease progression among patients coinfected with HIV and human T lymphotropic virus types 1 and 2. Clin Infect Dis 2004;39:256-263. [ Links ]
Received 5 November 2008. Accepted 17 December 2008.
Financial support: Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Fundação Oswaldo Cruz (FIOCRUZ)
Dr. Abelardo Araújo Instituto de Pesquisa Clínica Evandro Chagas / FIOCRUZ - Avenida Brasil 4365 - 21040-900 Rio de Janeiro RJ - Brasil. E-mail: firstname.lastname@example.org