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Retrocollis, anterocollis or head tremor may predict the spreading of dystonic movements in primary cervical dystonia

Retrocolis, anterocolis ou tremor cefálico podem predizer a progressão dos movimentos distônicos em pacientes com distonia cervical primária

Abstracts

BACKGROUND AND PURPOSE: Few studies have attempted to develop clinical predictors for cervical dystonia (CD) aiming at progression of the dystonic movement. METHOD: We retrospectively evaluated 73 patients with primary CD who underwent treatment with Botulinum toxin type-A (BTX-A). The patients were assembled in two groups according to the spread of dystonia during follow-up: spreading and non-spreading CD. We performed a binary logistic regression model using spreading of cervical dystonia as dependent variable aiming to find covariates which increase the risk of spreading. RESULTS: Our logistic regression model found the following covariates and their respective risk ratios: time of disease >18.5 months=2.4, retrocollis=1.9, anterocollis=1.8, head tremor=1.6. CONCLUSION: Time of disease >18.5 months, retrocollis, anterocollis and head tremor may predict spreading of dystonic movement to other regions of the body in CD patients.

cervical dystonia; progression; retrocollis; anterocollis; head tremor


INTRODUÇÃO: Poucos estudos avaliam preditores clínicos de progressão dos movimentos distônicos, para além da região cervical, em pacientes com distonia cervical (DC) primária. MÉTODO: Avaliamos, retrospectivamente, 73 pacientes com DC primária, que tinham sido submetidos ao tratamento com a toxina botulínica tipo A (BTX-A). Estes pacientes foram divididos em dois grupos de acordo com a progressão ou não da DC para outras áreas do corpo. Aplicamos um modelo de regressão logística binária usando a progressão da distonia como variável dependente com o objetivo de identificar co-variáveis que aumentassem o risco de progressão. RESULTADOS: O modelo de regressão logístico identificou as seguintes co-variáveis como preditoras de progressão e seus respectivos índices de risco: tempo de doença >18,5 meses=2,4, retrocolis=1,9, anterocolis=1,8, tremor cefálico=1,6. CONCLUSÃO: Tempo de doença >18,5 meses, retrocolis, anterocolis, e tremor cefálico podem predizer a progressão do movimento distônico para outras regiões do corpo em pacientes com DC primária.

distonia cervical; progressão; retrocolis; anterocolis; tremor cefálico


ARTICLES

Retrocollis, anterocollis or head tremor may predict the spreading of dystonic movements in primary cervical dystonia

Retrocolis, anterocolis ou tremor cefálico podem predizer a progressão dos movimentos distônicos em pacientes com distonia cervical primária

Clecio Godeiro-Junior; Andre Carvalho Felício; Patrícia Maria de Carvalho Aguiar; Vanderci Borges, Sonia Maria Azevedo Silva; Henrique Ballalai Ferraz

Movement Disorders Unit, Department of Neurology and Neurosurgery, Federal University of São Paulo, São Paulo SP, Brazil

ABSTRACT

BACKGROUND AND PURPOSE: Few studies have attempted to develop clinical predictors for cervical dystonia (CD) aiming at progression of the dystonic movement.

METHOD: We retrospectively evaluated 73 patients with primary CD who underwent treatment with Botulinum toxin type-A (BTX-A). The patients were assembled in two groups according to the spread of dystonia during follow-up: spreading and non-spreading CD. We performed a binary logistic regression model using spreading of cervical dystonia as dependent variable aiming to find covariates which increase the risk of spreading.

RESULTS: Our logistic regression model found the following covariates and their respective risk ratios: time of disease >18.5 months=2.4, retrocollis=1.9, anterocollis=1.8, head tremor=1.6.

CONCLUSION: Time of disease >18.5 months, retrocollis, anterocollis and head tremor may predict spreading of dystonic movement to other regions of the body in CD patients.

Key words: cervical dystonia, progression, retrocollis, anterocollis, head tremor.

RESUMO

INTRODUÇÃO: Poucos estudos avaliam preditores clínicos de progressão dos movimentos distônicos, para além da região cervical, em pacientes com distonia cervical (DC) primária.

MÉTODO: Avaliamos, retrospectivamente, 73 pacientes com DC primária, que tinham sido submetidos ao tratamento com a toxina botulínica tipo A (BTX-A). Estes pacientes foram divididos em dois grupos de acordo com a progressão ou não da DC para outras áreas do corpo. Aplicamos um modelo de regressão logística binária usando a progressão da distonia como variável dependente com o objetivo de identificar co-variáveis que aumentassem o risco de progressão.

RESULTADOS: O modelo de regressão logístico identificou as seguintes co-variáveis como preditoras de progressão e seus respectivos índices de risco: tempo de doença >18,5 meses=2,4, retrocolis=1,9, anterocolis=1,8, tremor cefálico=1,6.

CONCLUSÃO: Tempo de doença >18,5 meses, retrocolis, anterocolis, e tremor cefálico podem predizer a progressão do movimento distônico para outras regiões do corpo em pacientes com DC primária.

Palavras-chave: distonia cervical, progressão, retrocolis, anterocolis, tremor cefálico.

Clinical studies of dystonia have recognized a relationship between the age at symptom onset, affected body region at onset, and disease progression1,2. The natural history of cervical dystonia (CD) is not clear. The majority of patients deteriorates during the first five years, become static for the next 5 years, and then tend to show slight improvement3. Therefore, an important concern is the spread of CD to other body parts. Previous studies that evaluated clinical and demographic characteristics of patients with CD were not able to demonstrate predictable variables for the risk of CD progression4-8.

The Tsui scale score has been the most widely used instrument developed to follow-up patients with CD who undergo treatment with Botulinum toxin type-A (BTX-A). The parameters evaluated through this scale are amplitude and duration of sustained movements, shoulder elevation, pain and head tremor. The score ranges from 0 to 259. Unfortunately, this instrument can not be used to predict the natural history of CD.

The aim of our study was to find clinical and epidemiological predictors for CD to spread to other parts of the body.

METHOD

We retrospectively analyzed 184 charts of patients with CD who underwent medical treatment with BTX-A at the Movement Disorders Unit of our institution between 1990 and 2007.

We defined CD as primary, when there was no evidence on history, clinical and neurological examination or laboratory investigation of any identifiable cause of the dystonia; and secondary, when the cause of dystonia was identifiable such as anoxia, central (brain and spinal cord) or peripheral trauma, peripheral neuropathy, infection, metabolic disorder, previous use of neuroleptic drugs or when associated to other neurodegenerative disease such as atypical parkinsonism or Huntington' disease.

We identified 73 patients with primary CD and reviewed their medical chart for various demographic and clinical characteristics. We classified the patients according to gender, age of onset, family history of CD and Tsui scale score at first medical evaluation. Details of the dystonic movement at the first medical evaluation were reviewed: torticollis, anterocollis, retrocollis, laterocollis, head tremor and pain. We considered only dystonic head tremor with positive antagonistic geste and not overlapping essential head tremor.

The patients were divided according to the spread of dystonia during follow-up into two groups: spreading and non-spreading CD. We considered CD spreading when the dystonic movement extended to a different body region outside the cervical region. The pattern of progression included the following dystonic subtypes: blepharospasm, Meige syndrome, lower or upper limb dystonia, hemidystonia, multifocal or generalized dystonia.

Statistical analysis for continuous variables and comparisons between subgroups were performed by Student t-test (or Mann-Whitney test, for non-parametric data); for categorical variables, comparisons between groups were performed using the Chi-square test. Significant values of p were set at <0.05. The statistical analyses were performed using software Prism 3.0. Parametric data is presented as mean ± standard deviation (SD) and non-parametric data as median ± percentile (25th and 75th percentiles).

We also performed a binary logistic regression model using spreading of cervical dystonia as dependent variable and the following variables were candidates for covariates: familial history, onset age <28 years, time of disease >18.5 months, score Tsui >7.5, head tremor, pain, rotation, laterocollis, retrocollis and anterocollis. Time of disease is defined as the period between the first clinical presentation and the first clinical evaluation in our department. We chose onset-age <28 years as a candidate variable because it defines an early onset dystonia and patients in this category present a higher risk of spreading9,10. We transformed continuous variables (time of disease and Tsui score) into categorical ones (time of disease >18.5 months and score Tsui >7.5) appling ROC (receiver operating characteristic) curve method to our own data: the value with highest specificity and sensitivity for each variable was used as cut-off in the categorization process. To select the covariates we used likelihood ratio with value of significance of p<0.2. Variables identified as covariates (p<0.2) were included in a binary logistic regression model. These statistical analyses were performed using software SPSS 13.0 for Windows.

This protocol was submitted and approved by the Ethical Committee of our institution.

RESULTS

In 25 patients (34.3%), dystonia spreaded from the cervical region to other body regions. The occurrence of disease spreading presented a median of 24 (12-38, 25th and 75th percentiles) months. Clinical and demographic data of both groups are presented in Table 1.

In the spreading group most of patients presented rotation associated to anterocollis, retrocollis or laterocollis. In the non-spreading group, rotation or rotation associated with laterocollis. The phenomenology of CD in both groups is presented in Table 2.

The pattern of dystonia spreading was: blepharospasm in 8 (32%); generalized in 7 (28%); oromandibular in 4 (16%); upper limb in 2 (8%); Meige' syndrome in 1(4%); hemidystonia in 1 (4%); trunk in 1(4%); multifocal in 1 (4%). We did not observe isolated spreading to the lower limb. Fig 1 shows the pattern of spreading found.


In our model of logistic regression, the variable elected as covariates: time of disease >18.5 months, score Tsui >7.5 at first clinical evaluation, rotation, retrocollis, anterocollis and head tremor (Table 3). These variables were included as covariates in a binary logistic regression model using spreading as dependent variable. Table 4 shows the variables identified as predictors of spreading and their respective risk ratio and confidence intervals.

DISCUSSION

Among 73 patients with primary CD, 34.3% (n=25) had progression beyond the neck region, and our model of logistic regression identified predictors of spreading: time of disease >18.5 months, retrocollis, anterocollis, and head tremor.

In previous reports, the clinical characteristics of CD such as head tremor, pain and direction of the movement (rotation, laterocollis, anterocollis and/or retrocollis) have been suggested as predictors of remission, but not of progression4,5. In some reports, those patients without head tremor, without pain and with a simple form of CD had more chances of remission5,11. Our data suggest that in our group of patients, the presence of anterocollis (risk ratio=1.8), retrocollis (risk ratio=1.9) or head tremor (risk ratio=1.6) predicts a higher chance of spreading. Interestingly, there is no significant difference in the percentage of patients with these characteristics between spreading and non-spreading groups in their first medical evaluation (Table 1). Tsui score is even higher in the spreading group, suggesting that these patients presented a severe disease in their first medical evaluation. However, we found that a higher Tsui in the first medical evaluation (Tsui score >7.5) is not a predictor of progression, although it has a good association with the spreading outcome (likelihood ratio=3.81, p= 0.02). We calculated our model for different subsets of candidate variables, but only those presented in Table 4 were significant. We did not expect that Tsui score >7.5 was not a good predictor. However, Tsui score depends of different variables (rotation, anterocollis, retrocollis, laterocollis, duration of sustained movements, shoulder elevation, and head tremor) and was not designed as prognostic score, but as follow-up one for the treatment with BTX-A9. We believe that Tsui score was ranked as candidate variable but did not become a reliable predictor, because it is influenced by the time of disease and other variables included in our model such as anterocollis, retrocollis and head tremor.

It is known that in patients with early-onset dystonia (age<28 years) the symptoms tend spread more than in those with late-onset dystonia1,10. Our patients presented a late-onset CD and when we compared onset-age between groups, we observed that patients in the spreading group were older than those in the non-spreading group (45.7 ± 3.6 years vs. 37.1 ± 1.9, p=0.02). In our model of logistic regression, we considered onset-age <28 years as a candidate variable, but it had a weak association with progression in our group of patients (likelihood ratio=0.09, p=0.7).

We also observed that patients with time of disease >18.5 months have a higher risk of spreading (risk ratio=2.4). In our group of patients, those who spreaded their disease, presented this event in 24 (12 -38, 25th and 75th percentiles) months. Our data are in line with a previous report3, which concluded that most patients with CD deteriorate during the first five years. Spontaneous remission of CD is also described4,11, but we did not observe it in any of our patients. However, we must report that our patients in the non-spreading group are younger and present similar period of follow-up, when compared to the spreading one. We do not know if these patients, in a longer follow-up, will also spread, once they present the predictors of the spreading group: time of disease >18 months, anterocollis, retrocollis and head tremor.

The pattern of CD spread in our group of patients was noteworthy and somewhat different from previous reports that showed a predilection for spread to the cranial segment or to the upper limb6,7,12. In fact, most of patients spreaded to cranial segment, but we found a high prevalence of generalized spreading (28% of patients). Unfortunately, we did not test them for DYT1 mutation; it is known that patients with CD who are DYT1 mutation carriers are more prone to spread to generalized dystonia1,13.

Our study presented some limitations, especially due to its retrospective nature. Although data were based on information obtained from medical charts with the participation of different physicians throughout the period of this study, the final diagnosis and Tsui scale score were always made concurrent at least with one of the authors (HBF, VB, SMAS, PMCA), and the same standard protocol was used for diagnostic purposes and follow-up. An information that we could not analyze was the influence of the treatment with BTX-A on spreading pattern. All patients received BTX-A (either Botox® or Dysport®), but in different doses and number of injections.

In conclusion, our retrospective study showed that time of disease >18.5 months, retrocollis, anterocollis and head tremor are good clinical correlates to predict spreading of movement to other regions of the body of CD patients. We think that further prospective studies with a long follow-up should address the time of CD spreading beyond the neck region and the influence of BTX-A on spreading.

Received 27 October 2008, received in final form 23 January 2009.

Accepted 18 April 2009.

Dr. Clecio Godeiro-Junior - Rua Monsenhor José Paulino 1061/101 - 59022-200 Natal RN - Brasil. E-mail: cleciojunior@yahoo.com.br

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Publication Dates

  • Publication in this collection
    13 July 2009
  • Date of issue
    June 2009

History

  • Accepted
    18 Apr 2009
  • Reviewed
    23 Jan 2009
  • Received
    27 Oct 2008
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