Epidemiological and laboratory analysis of patients coinfected with HTLV-1 and HCV

THESES

Epidemiological and laboratory analysis of patients coinfected with HTLV-1 and HCV (Abstract)^*. Dissertation. Rio de Janeiro, 2010.

Alexandre Gomes Vizzoni^**

ABSTRACT: HTLV-1 is associated with adult T-cell leukemia and HTLV-1-associated myelopathy. HCV infection causes chronic hepatitis, cirrhosis, hepatocellular carcinoma and several extrahepatic diseases. Due to the role of cellular immunity in the development and progression of HCV-associated diseases, one could expect that interaction between HTLV-1 and HCV might modify the natural course of these infections.

OBJECTIVE: To evaluate the epidemiological and laboratory aspects of these infections.

METHOD: A cross-sectional study was conducted, 50 HTLV-1/HCV coinfected, 46 HCV and 50 HTLV-1 infected patients were randomly selected. Individuals with HBV and/or HIV infection were excluded.

RESULTS: Socio-demographic characteristics were similar in all groups. Alcohol drinking was more frequent in HCV group (p<0.001). Viral transmission by blood transfusion occurred in 80.6% of HCV group and in 39% of coinfected, and by drug addiction in 26.8% of coinfected. Sexual transmission (55.6%) was more frequent in HTLV-1 group (p<0.001). Neurological involvement was more frequent in coinfected and occurred in 72% of patients (p=0.001). Thrombocytopenia was more frequent in HCV group (p<0.001). Transaminase (ALT/TGO), alkaline phosphatase and total bilirubins levels were higher in HCV group when compared to HTLV-1/HCV group. No difference in HCV genotypes and viral load in HCV groups were observed. HTLV-1 proviral load were similar in HTLV-1 groups. Cryoglobulinemia was higher in HTLV-1/HCV patients, but no significant difference was observed when compared to other groups.

CONCLUSION: Our results suggest that coinfected patients were associated with a higher frequency of neurological involvement, and a less advanced degree of hepatic involvement, being necessary to follow-up these patients for a better evaluation of the interaction between the two viruses.

Key words: HTLV-1, HCV, peripheral neuropathy.

*

Análise epidemiológica e laboratorial de indivíduos coinfectados pelo HTLV-1 e HCV (Resumo). Dissertação de Mestrado. Instituto de Pesquisa Clínica Evandro Chagas - IPEC/FIOCRUZ (Área de concentração: Pesquisa Clínica em Doenças Infecciosas) Rio de Janeiro, RJ. Orientadores: Ana Claudia Celestino Bezerra Leite e Maria José de Andrada-Serpa.

Publication Dates

• Publication in this collection
  06 Jan 2011
• Date of issue
  Dec 2010