IMAGES IN NEUROLOGY
Primary dural lymphoma: a rare subtype of primary central nervous system lymphoma (PCNSL)
Linfoma primário dural: um raro subtipo de linfoma primário de sistema nervoso central (LPSNC)
Fabiano ReisI; Ricardo SchwingelII; Luciano de Souza QueirozIII; Verônica de Araújo ZanardiI
IMD, PhD, Department of Radiology of the Clinics Hospital of the State University of Campinas, Faculty of Medical Sciences, Campinas SP, Brazil
IIMedical Student, Department of Pathology of the Clinics Hospital of the State University of Campinas, Faculty of Medical Sciences, Campinas SP, Brazil
IIIMD, PhD, Department of Pathology of the Clinics Hospital of the State University of Campinas, Faculty of Medical Sciences, Campinas SP, Brazil
Correspondence Correspondence: Fabiano Reis Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Departamento de Radiologia Rua Tessália Vieira de Camargo 126, Caixa Postal 6111, 13083-887 Campinas SP - Brasil E-mail: fabianoreis2@gmail.com
A 56-year-old female with left VI nerve palsy. Diagnostic imaging demonstrated a left cavernous sinus lesion, with a pattern which may be associated to meningioma, lymphoma, inflammatory pseudotumor, tuberculosis or sarcoidosis (Fig 1).
Histological analysis confirmed the diagnosis of marginal zone B-cell lymphoma. Signal intensity and marked enhancement are due to dense cellularity (with high nucleus/cytoplasm ratios) and absence of necrosis (Fig 2).
Primary dural lymphoma is a rare form of PCNSL. It arises from dura mater, usually being a low-grade marginal zone lymphoma, while other types of PCNSL are usually high grade large B-cell lymphomas1-3.
Received 11 September 2010
Received in final form 15 October 2010
Accepted 25 October 2010
Support: Fapesp
- 1. Abdullah S, Morgensztern D, Rosado MF, Lossos IS. Primary lymphoblastic B-cell lymphoma of the cranial dura mater: a case report and review of the literature. Leuk Lymphoma 2005;46:1651-1657.
- 2. Kiewe P, Dallenbach FE, Fischer L, et al. Isolated B-cell lymphoproliferative disorder at the dura mater with B-cell chronic lymphocytic leukemia immunophenotype. Clin Lymphoma Myeloma 2007;7:594-596.
- 3. Sanjeevi A, Krishnan J, Bailey PR, Catlett J. Extranodal marginal zone B-cell lymphoma of MALT type involving the cavernous sinus. Leuk Lymphoma 2001; 42:1133-1137.
Publication Dates
-
Publication in this collection
26 Apr 2011 -
Date of issue
Apr 2011