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Arquivos de Neuro-Psiquiatria

versão impressa ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.70 no.4 São Paulo abr. 2012 Epub 31-Jan-2012

http://dx.doi.org/10.1590/S0004-282X2012005000005 

Sudden death in a patient with a third ventricle colloid cyst

 

Morte súbita em paciente com cisto coloide de terceiro ventrículo

 

 

Danilo SilvaI,II; Georgios MatisI; Olga ChrysouIII; Eduardo V. de Carvalho JuniorII; Leonardo CostaII; Matheus KitamuraII; Theodossios BirbilisIII; Hildo Azevedo FilhoII

INeurosurgical Department, Weill Cornell Medical College, New York NY, USA
II Neurosurgical Department, Restauração Hospital, Recife PE, Brazil
IIINeurosurgical Department, Democritus University of Thrace Medical School, Alexandroupolis, Greece

Correspondence

 

 

A 26-year-old female was brought to the Emergency Department for experiencing a sudden and progressive worsening of cephalalgia after sexual intercourse. She eventually became drowsy and not responsive to verbal commands. The patient had a medical history of third ventricle colloid cyst (CC), diagnosed in another institution, and had suffered intermittent headaches for two years.

The neurological examination revealed a patient in profound coma with a Glasgow Coma Scale score (GCS) of 3. Her pupils were bilaterally dilated, with no response to light stimulus. After emergency protocol procedures, the patient was admitted to the Intensive Care Unit (ICU) and a head computed tomography (CT) was obtained. The CT demonstrated hydrocephalus and a hyperdense lesion inside the third ventricle compatible with a previously known third ventricle CC (Fig 1 and 2). Due to the poor neurological status, no treatment was recommended and the patient died two hours after admission. Institutional ethics committee approval was obtained in order to proceed with this case report.

 

 

 

 

This is one of the very few cases of sudden death related to a third ventricle CC reported in the literature1-4. CCs are regarded as benign lesions1, accounting for 0.5 to 2% of intracranial tumours2. The cause of death is believed to be the result of acute cyst swelling due to an intralesional haemorrhage3,4. Its incidence varies from 1 to 3/106 person-years5,6. Estimates of the risk of acute deterioration in patients harboring these cysts vary from 6 to 45% with episodic headache and compromised consciousness, being the most common symptom and sign, respectively5. This leads to cerebral herniation as a result of ventricular obstruction after blockage of Monro's foramen1,5,6. Since cyst size, duration of symptoms, and presence of hydrocephalus cannot reliably predict the risk of sudden neurological deterioration5, surgical management is favored, even when the relationship between the CC and headache is unclear5,6.

 

References

1. Godano U, Ferrai R, Meleddu V, Bellinzona M. Hemorrhagic colloid cyst with sudden coma. Minim Invasive Neurosurg 2010;53:273-274.         [ Links ]

2. Hadar EJ, Schmunk GA, Salamat MS. Hemorrhagic colloid cyst in a patient with leukemia. Case illustration. J Neurosurg 1999;91:516.         [ Links ]

3. Malk GM, Horoupian DS, Boulos RS. Hemorrhagic (colloid) cyst of the third ventricle and episodic neurologic deficits. Surg Neurol 1980;13:73-77.         [ Links ]

4. Beems T, Menovsky T, Lammens M. Hemorrhagic colloid cyst: case report and review of the literature. Surg Neurol 2006;65:84-86.         [ Links ]

5. De Witt Hamer PC, Verstegen MJT, de Haan RJ, et al. High risk of acute deterioration in patients harboring symptomatic colloid cysts of the third ventricle. J Neurosurg 2002;96:1041-1045.         [ Links ]

6. Pollock BE, Huston 3rd J. Natural History of asymptomatic colloid cysts of the third ventricle. J Neurosurg 1999;91:364-369.         [ Links ]

 

 

Correspondence:
Danilo Silva
Weill Cornell Medical College, New York NY, USA
Department of Neurological Surgery
Skull base fellow
124 west 60th street Apt 37L
New York NY - USA
E-mail: daniloncr@gmail.com

Conflict of interest:
There is no conflict of interest to declare.

Received 21 October 2011
Received in final form 09 November 2011
Accepted 16 November 2011