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Print version ISSN 0004-282X
Arq. Neuro-Psiquiatr. vol.71 no.3 São Paulo Mar. 2013
Psychiatric disorders in patients with systemic lupus erythematosus
Transtornos psiquiátricos em pacientes com lúpus eritematoso sistêmico
Programa de Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento, Psiquiatria, na Universidade Federal de Pernambuco (UFPE), 2011, Tese de Doutorado
The frequency of psychiatric disorders associated with systemic lupus erythematosus (SLE) is variable.
The Mini International Neuropsychiatric Interview Plus was used in 131 women for the diagnosis of psychiatric disorders related with age, time and activity of the disease (SLEDAI-2K). Eighty women with SLE and 60 healthy women were genotyped by polymerase chain reaction. In 113 patients, the SF-36 was evaluated.
Major depressive episode (37.4%), Agorafobia (45.0%) and generalized anxiety disorder (34.4%) were the most common findings. Activity of the SLE was significantly associated with the presence of humor disorders, disorders of anxiety and suicide risk (p<0.05). Humor disorders, anxiety disorders and suicide risk presented greater tendency to the G/G genotype. The domains of SF-36 for physical function, vitality and mental health had significant results for all the disorders (p<0.05).
The activity of the SLE represented risk for the presence of humor and anxiety disorders. This study has presented evidences of the association between polymorphism in the promoter – 174 G/C of the gene IL-6. All SF-36 domains were shown to be related with psychiatric disorders.
Key words: lupus erythematosus, systemic; mental disorders; quality of life; interleukin-6; cytokines; polymorphism, genetic