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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.71 no.3 São Paulo Mar. 2013 


Psychiatric disorders in patients with systemic lupus erythematosus

Transtornos psiquiátricos em pacientes com lúpus eritematoso sistêmico

Nadja Maria Jorge Asano

1Programa de Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento, Psiquiatria, na Universidade Federal de Pernambuco (UFPE), 2011, Tese de Doutorado



The frequency of psychiatric disorders associated with systemic lupus erythematosus (SLE) is variable.


To identify the psychiatric disorders of patients with SLE.


The Mini International Neuropsychiatric Interview Plus was used in 131 women for the diagnosis of psychiatric disorders related with age, time and activity of the disease (SLEDAI-2K). Eighty women with SLE and 60 healthy women were genotyped by polymerase chain reaction. In 113 patients, the SF-36 was evaluated.


Major depressive episode (37.4%), Agorafobia (45.0%) and generalized anxiety disorder (34.4%) were the most common findings. Activity of the SLE was significantly associated with the presence of humor disorders, disorders of anxiety and suicide risk (p<0.05). Humor disorders, anxiety disorders and suicide risk presented greater tendency to the G/G genotype. The domains of SF-36 for physical function, vitality and mental health had significant results for all the disorders (p<0.05).


The activity of the SLE represented risk for the presence of humor and anxiety disorders. This study has presented evidences of the association between polymorphism in the promoter – 174 G/C of the gene IL-6. All SF-36 domains were shown to be related with psychiatric disorders.

Key words: lupus erythematosus, systemic; mental disorders; quality of life; interleukin-6; cytokines; polymorphism, genetic

Orientador: Prof. Dr. Otávio Gomes Lins

Coorientador: Profa. Dra. Maria das Graças Wanderley de Sales Coriolano

Correspondence: Rua Silveira de Carvalho 252; 52110-060 Recife PE - Brasil; E-mail:

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.