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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.71 no.7 São Paulo July 2013

http://dx.doi.org/10.1590/0004-282X20130073 

Theses

Phosphorus magnetic resonance spectroscopy in malformations of cortical development

Espectroscopia de fósforo por ressonância magnética em malformações do desenvolvimento cortical

Celi Santos Andrade1 

1Doutorado (Radiologia) na Faculdade de Medicina da Universidade de São Paulo (USP), 2011, São Paulo SP, Brazil.

ABSTRACT

Introduction

Malformations of cortical development (MCD) result from disruptions in the dynamic process of cerebral corticogenesis and are important causes of epilepsy, motor deficits and cognitive impairment.

Objectives

The aim of this study was to evaluate phospholipids metabolism in vivo in a series of patients with epilepsy and MCD.

Methods

Thirty-seven patients with MCD and 31 control subjects were studied using three-dimensional phosphorus magnetic resonance spectroscopy (31P-MRS) at a 3.0 T scanner. Quantification methods were applied to the following resonances: phosphoethanolamine (PE), phosphocholine (PC), glycerophosphoethanolamine (GPE), glycerophosphocholine (GPC), inorganic phosphate (Pi), phosphocreatine (PCr), and a-, b-, and g-adenosine triphosphate (ATP). The magnesium (Mg2+) levels and pH were calculated based on PCr, Pi and b-ATP chemical shifts.

Results

Compared to controls, the MCD lesions exhibited lower pH values and higher Mg2+ levels (p<0.05). The lesions also presented significant reduction of GPC and PDE, and an increased PME/PDE ratio. The otherwise normal appearing parenchyma also demonstrated lower pH values in the frontoparietal cortex and bilateral centrum semiovale.

Conclusions

Our data support the idea that metabolic impairments occur in the lesions of MCD, with propagation to remote normal appearing parenchyma. The results also suggest that there are membrane turnover disturbances in MCD lesions.

Key words: metabolism; epilepsy; phospholipids; hydrogen-ion concentration; magnesium; cell membrane

Correspondence: Celi Santos Andrade; Avenida Doutor Altino Arantes 370 / apto. 32; 04042-002 São Paulo SP - Brasil; E-mail: celis.andrade@hotmail.com

Orientadora: Professora Doutora Claudia da Costa Leite

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.