Sir, Japanese encephalitis is an important viral neurological infection. This viral infection can result in several neuropsychiatric manifestations11 . Goto A. Sequelae of Japanese encephalitis from the viewpoint of neuropsychiatry. Shinkei Kenkyu No Shimpo 1967;11:329-351,22 . Kawakatsu S. Encephalitis and psychosis. Ryoikibetsu Shokogun Shirizu 2003;40:303-306.. The most effective method for the control of this viral infection in the present is the use of vaccination. There are many kinds of available vaccines including inactivated mouse brain derived, inactivated cell culture derived and cell culture derived live attenuated JE vaccine33 . Saxena V, Dhole TN. Preventive strategies for frequent outbreaks of Japanese encephalitis in Northern India. J Biosci 2008;33:505-514.. However, the limitation of those vaccines is reported by several authors33 . Saxena V, Dhole TN. Preventive strategies for frequent outbreaks of Japanese encephalitis in Northern India. J Biosci 2008;33:505-514.,44 . Wiwanitkit V. Vaccination for tropical mosquito borne encephalitis. Acta Neurol Taiwan 2009;18:60-63.,55 . Wiwanitkit V. Vaccination against mosquito borne viral infections: current status. Iran J Immunol 2007;4:186-16.. Saxena and Dhole noted that the new advanced biotechnology could be applied in searching for new effective Japanese encephalitis vaccine33 . Saxena V, Dhole TN. Preventive strategies for frequent outbreaks of Japanese encephalitis in Northern India. J Biosci 2008;33:505-514.. An important focus proposed by the vaccine experts is to find one vaccine that can promote B cell activity66 . Konishi E. Memory B cells: a proposed new immunological correlate for protective efficacy ofJapanese encephalitis vaccine. Expert Rev Vaccines 2013;12:871-873.. Here, the authors report the use of advanced bioinformatics technique to find the ideal cell epitope within polyprotein of Japanese encephalitis virus. For this purpose, the used technique is ABCpred Prediction77 . Saha S, Raghava GPS. Prediction of continuous B-cell epitopes in an antigen using recurrent neural network. Proteins 2006;65:40-48., the same described in previous studies88 . Wiwanitkit V. Predicted B-cell epitopes of HER-2 oncoprotein by a bioinformatics method: a clue for breast cancer vaccine development. Asian Pac J Cancer Prev 2007;8:137-138.,99 . Wiwanitkit V. Predicted B-cell epitopes on 18 kDa antigen of Haemophilus ducreyi. Indian J Dermatol Venereol Leprol 2008;74:676-677.. The protein template in this study is “polyprotein [Japanese encephalitis virus]” (ACCESSION ABU94628). According to this study, the best identified peptide with the highest B cell epitope activity is 749GMSWITQGLMGALLLW following by 477YGEVTLDCEPRSGLNT. It is possible that the derived information from these studies can be useful for further development of new Japanese encephalitis vaccine.
References
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1Goto A. Sequelae of Japanese encephalitis from the viewpoint of neuropsychiatry. Shinkei Kenkyu No Shimpo 1967;11:329-351
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2Kawakatsu S. Encephalitis and psychosis. Ryoikibetsu Shokogun Shirizu 2003;40:303-306.
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3Saxena V, Dhole TN. Preventive strategies for frequent outbreaks of Japanese encephalitis in Northern India. J Biosci 2008;33:505-514.
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4Wiwanitkit V. Vaccination for tropical mosquito borne encephalitis. Acta Neurol Taiwan 2009;18:60-63.
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5Wiwanitkit V. Vaccination against mosquito borne viral infections: current status. Iran J Immunol 2007;4:186-16.
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6Konishi E. Memory B cells: a proposed new immunological correlate for protective efficacy ofJapanese encephalitis vaccine. Expert Rev Vaccines 2013;12:871-873.
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7Saha S, Raghava GPS. Prediction of continuous B-cell epitopes in an antigen using recurrent neural network. Proteins 2006;65:40-48.
-
8Wiwanitkit V. Predicted B-cell epitopes of HER-2 oncoprotein by a bioinformatics method: a clue for breast cancer vaccine development. Asian Pac J Cancer Prev 2007;8:137-138.
-
9Wiwanitkit V. Predicted B-cell epitopes on 18 kDa antigen of Haemophilus ducreyi. Indian J Dermatol Venereol Leprol 2008;74:676-677.
Publication Dates
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Publication in this collection
June 2014
History
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Received
29 Dec 2013 -
Reviewed
18 Feb 2014 -
Accepted
07 Mar 2014