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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.72 no.8 São Paulo Aug. 2014

http://dx.doi.org/10.1590/0004-282X20140109 

Articles

Hyperosmia in Lyme disease

Hyperosmia na doença de Lyme

Basant K. Puri 1  

Jean A. Monro 2  

Peter O. O. Julu 1   2   3   4   5   6  

Michele C. Kingston 2  

Mussadiq Shah 2   3   4   5  

1Department of Medicine, Imperial College London, London, UK;

2Department of Neuroscience, Breakspear Medical Group, Hemel Hempstead, Hertfordshire, UK;

3Queen Mary University of London, London, UK;

4The William Harvey Research Institute, London, UK;

5Barts and the London School of Medicine, London, UK;

6National Rett Center, Frösön, Sweden.

ABSTRACT

Neurological involvement in Lyme disease has been reported to include meningitis, cranial neuropathy and radiculoneuritis. While it is known that in some cases of asceptic meningitis patients may develop hyperosmia, the association between hyperosmia and Lyme disease has not previously been studied.

Objective

To carry out the first systematic study to ascertain whether hyperosmia is also a feature of Lyme disease.

Method

A questionnaire regarding abnormal sensory sensitivity in respect of the sense of smell was administered to 16 serologically positive Lyme disease patients and to 18 control subjects.

Results

The two groups were matched in respect of age, sex and body mass. None of the 34 subjects was suffering from migraine. Eight (50%) of the Lyme patients and none (0%) of the controls suffered from hyperosmia (p=0.0007).

Conclusion

This first systematic controlled study showed that Lyme disease is associated with hyperosmia.

Key words: olfaction; hyperosmia; Lyme disease

RESUMO

Tem sido descrito acometimento neurológico na doença de Lyme: meningite, neuropatia de nervos cranianos, e radiculoneurite. É bem conhecida a ocorrência de hiperosmia em alguns casos de meningites assépticas, mas a associação de hiperosmia com doença de Lyme ainda não foi relatada.

Objetivo

Conduzir um estudo sistemático para investigar se a hiperosmia é característica também da doença de Lyme.

Método

Foi aplicado um questionário pesquisando a ocorrência de sensibilidade anormal em relação ao sentido da olfação a 16 pacientes com sorologia positiva para doença de Lyme e a 18 controles normais. Os dois grupos foram pareados em relação a idade, sexo e massa corporal. Nenhum dos 34 sujeitos sofria de enxaqueca.

Resultados

Foi detectada hiperosmia em 8 sujeitos com doença de Lyme (50%) enquanto que a hiperosmia não apareceu em nenhum sujeito do grupo controle (p=0,0007).

Conclusão

Doença de Lyme está associada à hiperosmia.

Palavras-Chave: olfação; hiperosmia; doença de Lyme

The study was carried out at: Breakspear Medical Group, Hemel Hempstead, UK. B. K. Puri, MA, PhD, MB, BChir, BSc (Hons) MathSci, DipStat, PG Dip Maths, MMath, FRCPsych, FSB; Consultant Psychiatrist (Hammersmith Hospital), Adjunct Professor in Neuroimaging and Spectroscopy (UL); J. A. Monro, MB, BS, MRCS, LRCP, FAAEM, DIBEM, MACOEM; Medical Director of Breakspear Medical Group; P. O. O. Julu, MB, ChB, MSc, PhD; Senior Clinical Research Fellow (Imperial College London), Consultant Physician and Specialist Autonomic Neurophysiologist (Breakspear Medical Group), Consultant Autonomic Neurophysiologist (Queen Mary University of London), Consultant Neurophysiologist in Charge (National Rett Center, Frösön); M. C. Kingston, BA (Hons), BSc Nutri Med, mBANT; Clinical Nutritionist (Breakspear Medical Group); M. Shah, BSc, MSc, PhD; Clinical and Autonomic Neurophysiologist (Breakspear Medical Group), Senior Lecturer in Sensory System (Queen Mary University of London).

Olfaction is still poorly understood in humans; the main disorder of olfaction is anosmia or loss of the sense of smell1. Patients with hyperosmia complain of having an increased sensitivity of the sense of smell.

Lyme disease (also known as Lyme borreliosis) is a systemic arthropod-borne zoonosis caused by Borrelia spirochaetes, the incidence of which has recently been increasing with the geographical spread of infected ticks. It is well established that the bacteria can invade the skin (causing erythema migrans), musculoskeletal system (giving rise to Lyme arthritis), cardiovascular system (causing Lyme carditis) and the nervous system (Lyme neuroborreliosis), which may be associated with neuropsychiatric symptomatology2. In particular, neurological involvement in Lyme disease has been reported to include meningitis, cranial neuropathy and radiculoneuritis. It is known that in some cases of asceptic meningitis patients may develop hyperosmia3. However, to date, there have been no published studies regarding the relationship between Lyme disease and hyperosmia.

Therefore, the objective was to carry out the first systematic study to ascertain whether hyperosmia is a feature of Lyme disease.

METHOD

Subjects

This study was cross-sectional. Serologically positive Lyme disease patients attending the neuroscience department were included in the study if they were aged 18 years or over, but excluded from the study if they were suffering from migraine or if they had suffered olfactory lesions.

Written informed consent was obtained and the AONM research ethics committee approved the study under protocol number 003-2012. All participants signed an informed consent form before taking part in this study. The study was carried out in accordance with the Declaration of Helsinki.

Procedures

The date of birth, sex, body mass and past medical history of each subject were recorded. Each subject was asked whether or not he or she was unduly sensitive to odours.

Statistical analysis

Continuous variables for which data which did not differ significantly from normality and for which the two groups did not have significantly different variances were compared between the Lyme disease and control groups using independent samples t-tests (equal variances), while discrete nominal variables were compared between groups using Fisher’s exact probability test. All tests were two-tailed.

The software package used for the statistical analyses was IBM SPSS Statistics for Windows, Version 21.0.0.0 (64-bit edition) (IBM Corp, Armonk, NY, USA).

RESULTS

Sixteen serologically positive Lyme disease patients and 18 control subjects were studied. The two groups were matched in respect of mean age, sex ratio and mean body mass, as shown in Table.

Table Mean age, sex and mean body mass of Lyme disease patients and controls; standard errors are given in parentheses. 

Lyme disease n=16 Controls n=18 p-value
Mean age (y) 36.8 (4.1) 45.2 (3.9) 0.144ª
Sex 6 males, 10 females 7 males, 11 females 1b
Mean body mass (kg) 25.2 (1.2) 24.6 (0.8) 0.666ª

Eight (50%) of the Lyme disease patients and none (0%) of the controls suffered from hyperosmia (Fisher’s exact probability test, p=0.0007).

DISCUSSION

This first systematic controlled study showed that Lyme disease is associated with hyperosmia. In the sample studied, there was a highly significant prevalence of hyperosmia in Lyme disease of 50%.

Known migraineurs were excluded from this study and so it is unlikely that migraine could account for our finding. Again, as none of the subjects included in the study had clinical signs of meningitis, it is unlikely that meningitis could account for the high prevalence of hyperosmia in the Lyme disease group, although a subclinical form of meningitis associated with Lyme borreliosis cannot be ruled out as of importance. Finally, it should be noted that none of the medication taken by any of the patients is known to be associated with hyperosmia.

This is the first study of hyperosmia in Lyme disease. The high prevalence of this olfactory disorder found in our study suggests the need for further studies of olfactory function in this disease. It would also be of interest to carry out longitudinal studies to evaluate the response of hyperosmia to antibiotic pharmacotherapy.

References

. Gregorio LL, Caparroz F, Nunes LM, Neves LR, Macoto EK. Olfaction disorders: retrospective study. Braz J Otorhinolaryngol 2014;80:11-17. [ Links ]

. Biesiada G, Czepiel J, Lesniak MR, Garlicki A, Mach T. Lyme disease: review. Arch Med Sci 2012;8:978-982. [ Links ]

. Ropper AH, Brown RH: Adam and Victor's Principles of Neurology. 8th ed. New York, McGraw-Hill; 2005:198. [ Links ]

Received: April 25, 2014; Revised: May 16, 2014; Accepted: June 05, 2014

Correspondence: Basant K. Puri; Imaging Directorate; Block A, Level 1, Hammersmith Hospital, Du Cane Road, London W12 0HS, UK; E-mail: basant.puri@imperial.ac.uk

Conflict of interest: There is no conflict of interest to declare.

Creative Commons License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.