Sir, the report on “neurological complications after H1N1 influenza
vaccination11 Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological
complications after H1N1 influenza vaccination: magnetic resonance imaging
findings. Arq Neuropsiquiatr. 2014;72(7):496-9.
http://dx.doi.org/10.1590/0004-282X20140064
https://doi.org/10.1590/0004-282X2014006...
” is very
interesting. Lessa et al. reported that “H1N1 vaccination can result in important
neurological complications probably secondary to post-vaccination inflammation11 Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological
complications after H1N1 influenza vaccination: magnetic resonance imaging
findings. Arq Neuropsiquiatr. 2014;72(7):496-9.
http://dx.doi.org/10.1590/0004-282X20140064
https://doi.org/10.1590/0004-282X2014006...
” and “MRI detected
abnormalities in all patients11 Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological
complications after H1N1 influenza vaccination: magnetic resonance imaging
findings. Arq Neuropsiquiatr. 2014;72(7):496-9.
http://dx.doi.org/10.1590/0004-282X20140064
https://doi.org/10.1590/0004-282X2014006...
.”
In fact, the neurological problem can be seen in H1N1 influenza and the MRI finding in
the infected case is noted22 Zeng H, Quinet S, Huang W, Gan Y, Han C, He Y, Wang Y. Clinical and
MRI features of neurological complications after influenza A (H1N1) infection in
critically ill children. Pediatr Radiol. 2013;43(9):1182-9.
http://dx.doi.org/10.1007/s00247-013-2682-5
https://doi.org/10.1007/s00247-013-2682-...
. The
“diffuse prolonged T1 and T2 signal” is the main observation and this is
the similar finding to the present described finding in post H1N1 influenza vaccination
neurological complications11 Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological
complications after H1N1 influenza vaccination: magnetic resonance imaging
findings. Arq Neuropsiquiatr. 2014;72(7):496-9.
http://dx.doi.org/10.1590/0004-282X20140064
https://doi.org/10.1590/0004-282X2014006...
. In the
pharmacovigilance report, the myelin disorder, as detected by MRI finding11 Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological
complications after H1N1 influenza vaccination: magnetic resonance imaging
findings. Arq Neuropsiquiatr. 2014;72(7):496-9.
http://dx.doi.org/10.1590/0004-282X20140064
https://doi.org/10.1590/0004-282X2014006...
, is the common adverse effect reaction
due to H1N1 influenza vaccination33 Durrieu G, Caillet C, Lacroix I, Jacquet A, Faucher A, Quarest S et
al. [National Campaign of Vaccination against the flu A (H1N1)v: National
Follow-up of Pharmacovigilance]. Therapie. 2011;66(6):527-40. French.
http://dx.doi.org/10.2515/therapie/2011075
https://doi.org/10.2515/therapie/2011075...
.
Conclusively, MRI can be the good investigation for determining neurological
complication resulted by both influenza infection and vaccination.
References
-
1Lessa R, Castillo M, Azevedo R, Azevedo F, Azevedo H. Neurological complications after H1N1 influenza vaccination: magnetic resonance imaging findings. Arq Neuropsiquiatr. 2014;72(7):496-9. http://dx.doi.org/10.1590/0004-282X20140064
» https://doi.org/10.1590/0004-282X20140064 -
2Zeng H, Quinet S, Huang W, Gan Y, Han C, He Y, Wang Y. Clinical and MRI features of neurological complications after influenza A (H1N1) infection in critically ill children. Pediatr Radiol. 2013;43(9):1182-9. http://dx.doi.org/10.1007/s00247-013-2682-5
» https://doi.org/10.1007/s00247-013-2682-5 -
3Durrieu G, Caillet C, Lacroix I, Jacquet A, Faucher A, Quarest S et al. [National Campaign of Vaccination against the flu A (H1N1)v: National Follow-up of Pharmacovigilance]. Therapie. 2011;66(6):527-40. French. http://dx.doi.org/10.2515/therapie/2011075
» https://doi.org/10.2515/therapie/2011075
Publication Dates
-
Publication in this collection
Dec 2014
History
-
Received
25 July 2014 -
Reviewed
08 Aug 2014 -
Accepted
28 Aug 2014