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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282XOn-line version ISSN 1678-4227

Arq. Neuro-Psiquiatr. vol.73 no.8 São Paulo Aug. 2015

http://dx.doi.org/10.1590/0004-282X20150093 

ARTICLES

Migraine and tension-type headache triggers in a Greek population

Fatores desencadeantes de enxaqueca e de cefaleia tipo tensional em uma população grega

Vasilios Constantinides1 

Evangelos Anagnostou1 

Anastasia Bougea1 

George Paraskevas1 

Elisavet Kapaki1 

Ioannis Evdokimidis1 

Evangelia Kararizou1 

1Eginitio Hospital, Department of Neurology, Greece.

ABSTRACT

Migraine and tension type headache are the two most common primary headaches. The purpose of this study was to detect differences in clinical characteristics and headache triggers and in a Greek cohort of 51 migraineurs and 12 patients with tension-type headache. (TTH) Migraine patients had a significantly lower age at headache onset and frequency, higher mean visual analogue scale (VAS) and greater maximum duration of headache episodes compared to TTH patients. They did not differ from (TTH) patients in quality of headache, laterality of pain, way of headache installation and progression and temporal pattern of headaches. Nausea, vomiting and phonophobia were more frequent in migraine. Triggering of headaches by dietary factors was associated with migraine, whereas there was no difference between the two groups in any of the other headache triggers. Stress, both physical and psychological, were particularly common in both patient groups.

Key words: migraine; tension type headache; precipitating factors

RESUMO

Enxaqueca e cefaleia tipo tensional são as duas cefaleias primárias mais frequentes. O propósito deste estudo foi avaliar as diferenças e características dos fatores desencadeantes destas cefaleias numa coorte grega de 51 pacientes com enxaqueca e 12 com cefaleia tipo tensional. Pacientes com enxaqueca tinham uma idade significativamente menor por ocasião do início da cefaleia e maior frequência, maiores valores de (VAS) e maior duração dos episódios em comparação com os pacientes com (CTT). Não houve diferença entre os pacientes com enxaqueca e (CTT) com relação à qualidade e lateralidade da dor, na forma de instalação e progressão, e no padrão temporal das cefaleias. Náuseas, vômitos e fonofobia foram mais frequentes em enxaqueca. Fatores desencadeantes na dieta estavam associados à enxaqueca, enquanto não houve diferença entre os dois grupos para outros fatores desencadeantes. Estresse físico e psicológico foram particularmente prevalentes em ambos os grupos de pacientes.

Palavras-Chave: enxaqueca; cefaleia tipo tensional; fatores desencadeantes

Migraine is a primary headache that is usually severe, unilateral and throbbing in nature. It is often accompanied by photo – or phonophobia, nausea and vomiting and it worsens with physical activity1. A number of external and internal factors are considered triggers for migraine. Amongst them, the most common are stress, dietary factors, environmental factors, hormonal factors and sleep disorders.

Tension type headache on the other hand is the most common primary headache, and is characterized by bilateral location, pressing/tightening quality and of generally milder intensity compared to migraine. The accompanying symptoms of migraine (nausea, vomiting, photo- and phonophobia) are only rarely encountered in tension-type headache1.

The importance of these triggers (particularly stress and dietary factors) varies significantly among studies, presumably because of the different lifestyles and cultures of cohorts2,3,4,5.

The purpose of this article is to review the literature regarding trigger factors of headache and to present data about the prevalence of these trigger factors in a Greek cohort of migraineurs and patients with tension-type headache (TTH) in a Headache Clinic of a Tertiary Hospital in Athens.

METHOD

All patients examined at the Headache Clinic of Eginition Hospital during the period of 5/2011-5/2012 with a definite diagnosis of migraine without aura, migraine with aura or frequent episodic tension type headache, (according to the 2nd edition of the International Classification of Headache Disorders) were included in the study1. The study was approved by the Ethics Committee of Eginition Hospital. All the procedures were in accordance with the ethical standards with the Helsinki Declaration of 1975, as revised in 1983 and our patients were informed about that. In order to exclude secondary headaches, all patients underwent a complete neurological examination, basic blood tests, and brain imaging with CT or MRI, as well as more specialized tests when it was considered appropriate.

Demographic (age, gender) and clinical data were recorded for all the patients. Clinical data included age at disease onset, mean headache frequency and duration, mean and maximum headache severity (based on a visual analogue scale), presence (or absence) of a specific temporal pattern (e.g. headaches in the morning, midday, afternoon or evening) and of attacks that awaken the patient, way of attack installation (sudden or progressive), quality (pulsating, pressing, stabbing or mixed) and localization of headache.

All patients were asked about any association of their headache with the consumption of specific dietary triggers (alcohol, cheese, chocolate, citrus fruits, bananas), sleep disorders (insomnia and/or hypersomnolence), menstruation, the presence of mental and physical stress and weather - temperature changes.

The treating physician reported a headache characteristic or trigger factor as present or absent, based on the patient’s assessment during an interview. Although no formal questionnaires to quantify trigger characteristics were used, the questions were stereotyped.

All patients were furthermore asked about whether they considered that the recent financial crisis had affected them or not, without formal recording of the financial status of the patients. The Hamilton Anxiety Rating Scale (HAM-A) was administered, to objectively assess the anxiety levels of the patients.

Data on premonitory symptoms (fatigue, difficulty concentrating, yawning, pallor, neck stiffness), aura, associated (photophobia, phonophobia, nausea, vomit, conjuctival injection, rhinorrhoea, eyelid edema, miosis – ptosis, facial sweating), relieving (sleep, local pressure, shower etc) and aggrevating factors (especially headache worsening with physical activity) were recorded.

Continuous data were analyzed by independent samples t-test and categorical data by x2 test.

RESULTS

Of the 207 patients examined, 63 patients met the criteria for definite migraine and tension-type headache. 39 (62%) suffered from migraine without aura, 12 (19%) from migraine with aura (19%) and 12 (19%) from tension-type headache. Most of the remaining patients suffered from other primary or secondary headaches. Female/male ratio was 6:1, mean patient age was 40.7 years and mean age at headache onset was 22.8 ± 0.9 years. Patients had a mean VAS of 7.1 ± 1.9 (maximum VAS 9.6 ± 0.8), mean days of headache per month 7.3 ± 8.7 episodes/month and mean headache episode duration of 25.4 ± 36.9 hours.

Migraine patients had a significantly lower age at headache onset, fewer days of headache per month, higher mean visual analogue scale (VAS) and greater maximum duration of headache episodes compared to TTH patients. The two groups did not differ in their age and in mean headache duration (Table 1).

Table 1 Comparison of headache characteristics between the 2 groups. 

  Migaine Tension type headache p-value
N 51 12  
Age at headache onset 21.2 ± 10.4 29.4 ± 11.5 0.019
Age 41.4 ± 12.9 37.5 ± 15.5 0.429
Sex (male/female) 8 / 43 1 / 11  
Frequency of headache episodes (per month) 5.0 ± 5.4 17.1 ± 12.1 0.0001
Max episode duration (hours) 67.6 ± 65.5 19.0 ± 32.1 0.045
Mean episode duration (hours) 28.0 ± 38.4 10.4 ± 23.3 0.08
MaxVAS 9.9 ± 0.5 9.0 ± 1.3 0.114
MeanVAS 7.4 ± 1.6 5.5 ± 2.2 0.001
Quality of headache      
 Pulsating 13 2  
 Pressing 5 2  
 Stabbing 11 7  
 Pulsating + pressing 14 1 0.237
 Pulsating + stabbing 2 0  
 Pressing + stabbing 2 0  
 All 3 types 2 0  
Laterality (unilateral/bilateral) 27/22 3/9 0.062
Location      
 Retroorbital 20 1  
 Frontal 17 3  
 Parietal 1 1 0.001
 Temporal 1 5  
 Occipital 7 2  
 Diffuse 5 0  
Nausea (yes/no) 35/16 4/8 0.023
Vomitting (yes/no) 18/33 0/12 0.015
Photosensitivity (yes/no) 38/13 7/5 0.264
Sound sensitivity (yes/no) 38/13 4/8 0.006
Hamilton Anxiety Rating Scale 8.7 ± 7.6 11.4 ± 7.8 0.368

VAS: visual analogue scale.

Migraine patients did not differ from TTH patients in quality of headache, laterality of pain, way of headache installation and progression and temporal pattern of headaches. However, migraine presented more frequently in the retrobulbar/frontal region, whereas TTH mainly occurred in the temporal region (Table 1).

Regarding accompanying symptoms, nausea, vomiting and phonophobia differed significantly between the two groups (more frequent in migraine). Photophobia and the occurrence of vasomotor type disorders (eye redness - tearing - nasal congestion) did not differ between the two groups (Table 1).

Triggering of headaches by dietary factors (when asked as a general term) was associated with migraine (p = 0.019). Alcohol was a more common headache trigger factor in migraine patients (p = 0.044). However, the two groups did not differ when specific food items were analyzed separately (chocolate, cheese, citrus fruits, bananas). Sleep disorders, menstruation, changes in temperature/weather did not differ in the two groups. There were no differences between migraine and TTH patients in relieving and aggravating factors. Stress, both physical and psychological, was particularly common in both patient groups (Table 2). However, the two groups did not differ in their anxiety levels, as measured by the Hamilton Anxiety Rating Scale.

Table 2 Comparison of trigger factors between the 2 groups. 

  Migaine Tension type headache p-value
Menses (yes/no) 27 / 16 5 / 6 0.296
Stress (yes/no) 27 / 24 8 / 4 0.389
Fatigue (yes/no) 13 / 36 3 / 9 0.914
Food (yes/no) 17 / 34 0 / 12 0.019
Alcohol (yes/no) 13/ 36 0 / 12 0.044
Chocolate (yes/no) 5 / 44 0 / 12 0.248
Cheese (yes/no) 2 / 47 0 / 12 0.477
Bananas (yes/no) 1 / 48 0 / 12 0.618
Insomnia (yes/no) 19 / 32 1 / 11 0.053
Hypersomnolence (yes/no) 3 / 48 1 / 11 0.754
Temperature (yes/no) 10 / 41 2 / 10 0.815

DISCUSSION

Our study revealed many of the known clinical differences of patients with migraine compared to TTH2,3,4,5,6,7.

Patients with migraine exhibited a lower age of headache onset, fewer days of headache per month, increased intensity and duration of headache, different localization of pain, greater frequency of nausea, vomiting and phonophobia. However, there was no difference in the laterality of pain, quality of pain and presence of photophobia between migraine and TTH, three characteristics that are considered established discriminators between the two headache types.

This could be attributed to the relatively small sample size of our study. Furthermore, some of these characteristics were divided in many categories (e.g. quality of headache), thus requiring a larger sample to reach statistical significance. A selection bias should also be taken into consideration, since the patients examined at a University hospital are likely to differ from the general population, representing more atypical, complex or difficult to treat cases.

Despite not reaching statistical significance, migraine patients exhibited a clear tendency towards more frequent unilateral, throbbing headaches with accompanying photosensitivity compared to TTH patients, as expected.

In terms of triggers, only dietary factors (as a group) and alcohol were associated with migraine in our study. This relationship is well established in the literature2,3. No other specific food item was a statistically significant trigger in our study, although again there was a clear tendency of more frequent report of chocolate as trigger in migraine patients.

Most studies support the relationship between migraine and alcohol consumption, which is considered a major trigger factor of migraine attacks1,2,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21. However this relationship is complex and depends on many factors. The type of beverage is of some importance. Most studies consider red wine to be the most important migraine trigger2,9,12. Other studies however disagree5,11. The importance of white wine and beer is controversial9,10,11,12,18,22. Milde-Bush et al. report the importance of cocktails as a triggering factor for both migraine and TTH23. Aaamodt et al. reported a decrease in migraine attacks with an increase of alcohol consumption24.

Alcohol consumption was a trigger in 27% of the migraineurs in our study, in agreement with the literature, but did not relate with tension-type headache. Red wine was the commonest trigger. Beer and cocktails did not relate to migraine attacks.

Insomnia was a relatively common migraine trigger (19 out of 51 patients) in our study. However, only 1 of 12 patients with tension-type headache reported insomnia as a trigger. This difference was important, but did not reach statistical significance (p = 0.053).

Sleep disturbances have been extensively studied and seem to be of some importance in both migraine and TTH. Bruni et al. reported that poor sleep quality was the commonest headache trigger (migraine or not)25. Kelman et al. also reported a high frequency of sleep disturbances in migraineurs (difficulty in sleep initiation and maintenance, reduction of total sleep hours)26. Bruni et al. concluded that improvement of sleep quality resulted in a reduction of migraine attack severity and frequency27.

Stress did not differ between migraine and TTH patients in our study (as measured by HAM-A), despite the fact that stress is considered a traditional migraine trigger. However, 27 out of 51 patients with migraine and 8 out of 12 with tension type headache considered stress to be an important headache trigger. These results emphasize the importance of stress in both migraine and TTH.

The recent financial crisis in Greece could play a part in the elevated levels of stress in both study groups. Although the majority of patients reported that they were affected by the financial crisis, we did not include a formal questionnaire to assess the possible interaction between the financial crisis, stress and the occurrence of headache. A currently ongoing study in our clinic is specifically designed to answer this complex interaction.

Zivadinov et al. reported that contrary to widespread belief, stress was a more common trigger factor in migraineurs and physical activity in TTH. Other frequent precipitating factors included frequent travels and changes in weather conditions. Migraine with aura (MA) correlated with frequent travelling, dietary factors and weather conditions, compared to migraine without aura (MWA)2.

Another population based study in Iraq, reached the conclusion that psychological upset, physical activity and changes in weather conditions were the most important precipitating factors in migraine patients28. The results of a study by Theeler et al.on a mainly military population with headache were similar to the previous studies. Environmental factors, stress, dietary factors and fatigue were the most common headache triggers3.

Hansen et al. reached similar conclusions in their study of trigger factors in patients with familial hemiplegic migraine. Stress, intense light, emotional turmoil and increased or decreased sleeping hours were the most often reported trigger factors29.

Another cross-sectional study by Camboim et al. considered stress, environmental and hormonal factors to be the most important trigger factors for a migraine attack. The majority of patients reported susceptibility to a multitude of trigger factors (> 5)30.

Our study is in agreement with the literature in regard to the most common migraine triggers such as dietary factors, alcohol and sleep. We could not establish any difference between TTH and migraine patients in the frequency of specific food items consumption and stress, which are also considered classic migraine triggers.

Some differences between the two study groups were important but did not reach a level of statistical significance. This could be attributed to the relatively small sample size of our study. This is supported by the clear tendency towards more frequent occurrence of menses and chocolate in migraine patients compared to TTH patients, factors that are well established migraine triggers.

All trigger factors were based on the patient’s assessment during an interview. We did not include quantitative data regarding the frequency and severity of the triggers. Thus it is conceivable, that although TTH and migraine patients in our study did not differ in the frequency of some triggers, they might differ in their clinical importance (e.g. severity).

Our study population is not representative of the general population, because patients who refer to a university hospital tend to have more severe, atypical or difficult to treat symptoms. Thus a selection bias cannot be excluded. However it is important to present data on the cohorts that are examined in hospital environments, to highlight the differences with population-based data.

Despite these shortcomings, data recorded systematically in a hospital environment by trained physicians are more robust than data from cross-sectional population studies and diagnosis accuracy is significantly improved in a clinical environment compared to data from self-administered questionnaires.

Most data on the subject derive from cross-sectional population or retrospective studies. Study populations, inclusion criteria, study design and methodology vary considerably, prohibiting safe conclusions on the subject.

Ideally, a population based study, with data collected by trained physicians would provide concrete data on the subject of triggers of primary headaches. These data would be relevant in a clinical level, aiding differential diagnosis of primary headaches and promoting avoidance behavior as part of headache treatment. Furthermore, it would help elucidate the pathophysiological mechanisms underlying each primary headache, thus promoting more targeted therapies of these difficult to treat conditions.

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Received: August 06, 2014; Revised: March 27, 2015; Accepted: April 15, 2015

Correspondence: Vassilios Constantinides; Eginitio Hospital, Department of Neurology; Vassilisis Sofias 72-74, Athens Attica 11528, Greece; E-mail: vassilis.kon@hotmail.com

Conflict of interest: There is no conflict of interest to declare.

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