Aristides Azevedo Pacheco Leão (1914-1993) (Figure 1),
was my teacher and a leading neuroscientist of his time11 .Maranhão-Filho P., Vincent MV. Professor Aristides Leão. Much more than
spreading depression. Headache. 2009;49(1):110-6.
http://dx.doi.org/10.1111/j.1526-4610.2008.01210.x
https://doi.org/10.1111/j.1526-4610.2008...
. I once asked him why he selected the term “depression” in the
phenomenon he revealed in 1944. Leão replied that the terms extinction, suppression,
suppressive area, and inhibition had been suggested, but that spreading depression seemed more
appropriate. While answering (as usual), he took notes on a piece of paper with his pencil.
Almost 25 years later, I found this note (Figure 2).
Spreading depression is a curious transient property of the nervous tissue, which continues to
challenge neurologists and physiologists around world22 .Ferreira HM. Notas biográficas. In: Academia Brasileira de Ciências.
Aristides Azevedo Pacheco Leão. Rio de Janeiro: Academia Brasileira de
Ciências; 1994:11-12..
Prof. Aristides Leão’s own hand notes. Expressions suggested to name his phenomenon (arrows). Bottom left: exposed cortex with spreading depression passage, and wires connected to the voltmeter. In this, as in the cortex drawn next to it, observe the sequential arrangement of microelectrodes (dotted) that Leão devised to demonstrate the phenomenon’s characteristic spreading.
References
-
1Maranhão-Filho P., Vincent MV. Professor Aristides Leão. Much more than spreading depression. Headache. 2009;49(1):110-6. http://dx.doi.org/10.1111/j.1526-4610.2008.01210.x
» https://doi.org/10.1111/j.1526-4610.2008.01210.x -
2Ferreira HM. Notas biográficas. In: Academia Brasileira de Ciências. Aristides Azevedo Pacheco Leão Rio de Janeiro: Academia Brasileira de Ciências; 1994:11-12.
Publication Dates
-
Publication in this collection
Aug 2015
History
-
Received
09 Mar 2015 -
Reviewed
26 Mar 2015 -
Accepted
14 Apr 2015