Services on Demand
On-line version ISSN 1678-4782
J. Pediatr. (Rio J.) vol.80 no.2 suppl.0 Porto Alegre Apr. 2004
Carolina R. SchirmerI; Denise R. FontouraI; Magda L. NunesII
therapist. Graduate student, Program of Children's Neurology and Neuropsychology,
Service of Neurology, Hospital São Lucas, Pontifícia Universidade
Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil
IIAssociate professor, School of Medicine, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil
aid health professionals, especially pediatricians, in the diagnosis and prevention
of language and learning disorders.
SOURCES OF DATA: Review of the relevant literature published in the past 5 years (MEDLINE and textbooks).
SUMMARY OF THE FINDINGS: Multiple variables, among them neurological diseases, may be related to the etiology of language and learning disorders.
CONCLUSION: An adequate diagnostic investigation may guide the choice of treatment.
Key Words: Language disorders, learning disorders, dyslexia, autism, epilepsy.
Most of the problems reported in clinical pediatrics, neurology, neuropsychology and speech therapy are related to learning disabilities and/or developmental language disorders.
Learning disabilities are believed to be closely related to a past history of developmental language disorders. Learning disabilities are concerned with abnormal development of verbal and/or written expression and reception. Therefore, the early detection of these disabilities prevents later educational and social consequences.1
The aim of the present study is to provide health professionals, especially pediatricians, with adequate tools, so as to diagnose and prevent oral and written language disorders. To start with, we focus on the normal language developmental process, the neurobiological and environmental causes of these disorders, showing their implication on several developmental stages. Finally, we present a brief therapeutic approach.
Language is an example of higher cortical function, and its development is based on a genetically defined anatomic and functional structure, and on verbal stimuli provided by the environment.2
Language is a means of communication, that is, it is a social instrument of interaction used for communication. Thus, language should be regarded as a dynamic force or process instead of a product. It may be defined as a conventional system of arbitrary symbols, combined systematically to store and exchange information.3
Before children can speak, they use their eyes, facial expression and gestures to communicate with others. They can also distinguish sounds of speech. Learning the linguistic code is dependent upon the acquired knowledge about objects, actions, places, properties, etc. It results from the complex interaction between innate biological abilities and environmental stimuli, advancing according to neuropsychomotor development.1,4
Although the level of efficiency with which language is acquired, is not well established, it is common knowledge that children from different cultures follow the same global path of language development. While still in utero, they learn the sounds of their native language, and in their first months of life, they distinguish these sounds from those of other languages.3,5
Two distinct phases of language development exist: the prelinguistic phase, with vocalization of sounds but no words, which persists up to the 11-12th month of life; and the linguistic phase, when infants start to utter single but meaningful words. Later on, language expression becomes complex. This is a continuous process that occurs in an orderly and sequential fashion, with considerable overlapping of different developmental stages6 (Table 1).
Language acquisition encompasses the development of four interdependent systems: pragmatic (communicative use of language in a social context), phonological (perception and production of sounds to form words), semantic (processing of meaning), and grammatical (use of syntactic and morphological rules to combine words into meaningful sentences). The phonological and grammatical systems constitute the language form. The pragmatic system describes how language should be adapted to specific social situations in order to convey emotions and reinforce meanings.5
Intention to communicate may be expressed nonverbally through facial expression, signs, and also by children's ability to answer questions, wait for their turn, make questions and discuss their point of view. This communicative competence shows that knowing to adapt language to a given situation and knowing the rules for social communication is as important as semantic and grammatical awareness.3
Biological aspects of language
The language process is quite complex, and consists of a neuronal network distributed through different regions of the brain. In contact with environmental sounds, speech is comprised of multiple sounds that occur simultaneously at different frequencies and with increased variability. The ear must tune into this complex auditory signal, decipher it and translate it into electric impulses, which are carried by nerve cells to the auditory region of the cerebral cortex (temporal lobe). There, impulses are reprocessed and transmitted to language areas, where the acoustic signal is probably stored for a certain period of time.2
Wernicke's area, in the temporal lobe, recognizes the pattern of auditory signals and interprets them until concepts or thoughts are obtained, activating a distinct group of neurons for different signals. Neurons are also activated in the lower portion of the temporal lobe, forming an image of what was heard, whereas neurons in the parietal lobe store related concepts. According to this model, the neuronal network forms a complex processing unit.
The inverse process is necessary for verbalization of thoughts. Initially, there is an inner representation of the topic, which is organized into Broca's area, in the lower portion of the frontal lobe and converted into patterns of neuronal activation necessary for the production of speech. Areas responsible for motor control and memory are also involved in language development.7
The brain is a dynamic organ that is always adapting to new information; consequently, the areas associated with language in adult individuals might not be the same in children. Some brain zones might be used only during language development.8
The left hemisphere is believed to be language dominant in approximately 90% of the population, however, the right hemisphere is responsible for processing information, especially with respect to pragmatic aspects.9,10
Etiology of oral and written language disorders
Speech involves articulation, resonance, voice, fluency/rhythm and prosody. Language difficulties are among the most frequent developmental disabilities, affecting 3-15% of children. They may be classified into delay, dissociation, and deviance11 (Table 2).
The etiology of language and learning disorders varies considerably, and may include organic, intellectual/cognitive, and emotional factors (relational familial structure), and these factors are most times correlated. Learning disabilities may co-occur with other conditions (mental retardation, emotional disorders, sensory/motor disorders) or may be exacerbated by external factors, such as cultural differences, poor or inadequate education12,13 (Table 3).
Language and epilepsy
The effects of epilepsy, seizures and electroencephalographic discharges on language have been widely discussed in several studies. The most frequent disorders observed in epileptic patients are: developmental dysphasia associated with epilepsy; acute aphasia (transient dysfunction of the cognitive function), and acquired epileptiform aphasia (Landau-Kleffner syndrome).14,15 Acquired epileptiform aphasia is characterized by deterioration of spoken language associated with seizures or abnormal epileptiform electroencephalographic activities, being often mistaken for autistic syndrome or hearing impairment. On top of deterioration of speech and auditory agnosia, behavioral disorders, including autistic traits, are also observed. Therefore, it is essential to keep an eye on children who have language regression, evaluating them carefully so that a differential diagnosis is established and proper treatment is provided.16-18
Language and autism
Language regression is observed in Landau-Kleffner syndrome and in autistic regression.14,19,20 Recent studies, which focus on the language of verbal children on the
autistic spectrum, emphasize aberrant features of their speech such as
unusual word choices, pronoun reversal, echolalia, incoherent discourse, unresponsiveness to questions, aberrant prosody and lack of drive to communicate.21,22 Several studies attribute the lack of speech of some individuals to the severity of their autism, mental retardation, or to an inability to decode auditory language.21 In autism, comprehension and pragmatics are always affected, and findings include aberrant prosody, immediate or late echolalia and perseveration (inappropriate repetition of a utterance). Other symptoms, which are different from those observed in children with speech delay, are nonverbal communication disorders, stereotyped and persistent behaviors, restricted and/or unusual interests and impaired social interaction.23 Our conclusion is that language regression in children is a severe disorder with significant long-term comorbidities.24
Intervention in children with speech disorders
Speech and language development may be appropriate or not, depending on chronological age. Evaluation should include cognitive and emotional aspects of development, which may indicate or not the severity of the disorder, as well as the necessity for specialized family guidance and/or speech therapy.24 It is widely known that early language stimulation may prevent learning disabilities, dyslexia, and developmental disabilities. A body of research has demonstrated the importance of the first three years of life to the development of the human brain.25,26
The basic interventions include the evaluation of language development at all levels, family and school guidance, and therapy.1,24 Types of therapy include speech therapy (phonetic and phonological deviations), voice therapy (dysphonias), oral motor therapy (eating disorders, breathing and mobility of phonoarticulatory organs), oral speech therapy (expressive and/or receptive language) and written language therapy (dyslexias, dysorthographies and dysgraphias).
All stimulation activities in a child's speech therapy must be carried out in a playful way (e.g.: games), so that children find them amusing, and should encourage the participation of family and school, if necessary.1
Stimulation through singing, talking, playing games, and reading allow for the acquisition of skills that foster development. For the process of communication to occur, children need to be motivated. There should be the so-called intention to communicate (children can obtain their objects of interest through language). This occurs through the daily contact with people and through the stimuli that such interaction provides. The importance of breastfeeding, foods with adequate texture and consistency at different stages, and the elimination of thumb sucking or pacifiers at the age of two years should also be emphasized. All of these factors contribute to an orofacial musculature that facilitates speech development. Family has a crucial role in stimulating speech; it is the physician's or therapist's decision to let the family get involved or let himself/herself be involved by the family.26
According to constructivism, learning is construction, action and awareness of the coordination of actions, where knowledge is built from learners' personal experience, with a previous learning structure or conditions, in addition to exposure to the necessary learning contents.27
Specific reading and writing development is related to a wide series of factors, which are underpinned by the mastery of language and capacity of symbolization, and that depend on internal and external conditions.28
Reading skills are verified by child's ability related to decoding, fluency and written comprehension.29 Normal reading occurs in two phases. First, the graphic stimulus is visually processed. Afterwards, linguistic processing takes place, where letters are converted to sounds through the nonlexical route, and then words are globally read as to their meaning via the lexical route.30,31 The child should find out that some letters do not correspond to the speech sound, since "alphabetical reading associates an auditory phonemic component with a graphic visual component, which is known as graphophonemic correspondence".32 It is necessary to be aware of the phonemic structure of language (word segmentation) and of the auditory units represented by different graphemes.33
The process of written language acquisition, as occurs with oral language, involves various regions of the brain, including the parieto-occipital area. In the occipital region, the primary visual cortex is responsible for processing graphic symbols, and parietal lobe areas are responsible for visuospatial aspects of writing. This processed information is recognized and decoded by Wernicke's area, which is responsible for language comprehension, and the expression of written language requires the activation of the primary motor cortex and Broca's area. For all this process to occur, intra-hemispheric connections must be intact.7
A study conducted with healthy individuals asked to read pseudo-words revealed activation of the left inferior frontal region; parieto-temporal region, involving the angular and supramarginal gyri, and posterior portion of the superior temporal gyrus; and occipito-temporal regions, involving mesial and inferior portions of the temporal and occipital gyri.27 The same study was carried out with dyslexic patients, and revealed an increase in the activation of the inferior frontal gyrus and little activation of posterior regions.
Researchers have shown that as far as neurological mechanisms involved in reading disabilities are concerned, hemispheric asymmetry produces an atypical organization of the right hemisphere in dyslexic children and adolescents.34
Dyslexics have a temporo-parieto-occipital disconnection and a disconnection with the left frontal cortex, as well as other problems between the temporo-parietal cortex and the cerebellum and other brain regions.33
Written language disorders in childhood
Learning disabilities refer to the abnormal development of reading and written skills, and logical and mathematical thinking, and may be associated with oral language impairment.34-36
When investigating oral language disorders, it is common to find predictors of subsequent reading and writing disabilities. Likewise, when we investigate the factors that predispose to reading and writing disabilities, questions about language learning difficulties are raised. It has been underscored that among oral language difficulties in children, phonological difficulties may interfere with later development of reading and writing skills, and not articulation disorders, as previously thought.37
Reading and writing encompass complex cognitive skills, in addition to the ability to reflect upon the language in phonological, syntactic, semantic and pragmatic terms.
When children are introduced to writing they already master the oral language, being therefore able to learn how to write. However, we know that there are specific rules that apply to writing, which make its learning more difficult.38
In Brazil, around 40% of children who are learning to write have problems with their school performance. This rate drops to 20% in industrialized countries.38,39 If children with learning disabilities are properly followed by health professionals and educators, conjointly with the family, they can succeed in school.13
As a matter of fact, there is a combination of biological and environmental factors in written language acquisition, including motor integrity, sensory perceptual integrity and social and emotional integrity (actual possibilities offered by the environment in terms of quantity, quality, and frequency of stimuli). Moreover, the mastery of language and the ability to interpret symbols are important for the development of reading and writing skills.40,41
Dyslexia is a learning disability characterized by specific reading and writing difficulties. There are two types of dyslexia: developmental dyslexia and acquired dyslexia.38,42 Developmental dyslexia refers to reading and writing disorders of environmental origin (related to learning style). In this case, reduced reading ability is associated with cerebral dysfunction, denoting a specific problem with the development of reading skills, and consequently, with learning to read.33 Some authors think genetic factors are implicated in the etiology of developmental dyslexia. In acquired dyslexia, acquired reading and writing skills are lost, due to brain damage.
Several factors related to the etiology of developmental dyslexia have been under investigation, including cognitive deficits, neurological (neuroanatomical and neurophysiological) factors, premature birth, low birthweight, genetic and environmental factors. However, external (environmental) factors cannot be dissociated from neurological problems, since aspects such as poor education, emotional disorders, and poor stimuli during childhood may cause differences in the neurological and cognitive development, leading to severe reading disabilities.41,43,44
Dyslexias may be of two types: central and peripheral (Table 4). In central dyslexias, linguistic processing is undermined, that is, the letter-to-sound conversion is impaired. In peripheral dyslexias, the visual perceptual system is compromised, and the understanding of what has been read is then hindered.
Central dyslexias can be subdivided into phonological, surface, and deep dyslexias, whereas peripheral dyslexias are subdivided into attentional, neglect and pure dyslexias.29
With regard to developmental dyslexias, the most common ones are phonological dyslexia, surface dyslexia, and semantic dyslexia. The latter is characterized by reading aloud, with perfect letter-to-sound conversion, but poor written comprehension.45
Several studies have provided evidence of phonological deficits in developmental dyslexia. Nevertheless, recent studies have gathered evidence of multiple temporal processing deficits in dyslexias. Actually, dyslexics have visual and auditory disorders, which may result from generalized problems with perception and selection of stimuli.
Dyslexic children have auditory and visual disorders related to spatial orientation. These findings suggest that poor utilization of allocated space may tamper with the development of phonological and orthographic representations that are essential to reading acquisition.46
A study conducted by the Institute of Cognitive Neuroscience (London) assessed 16 dyslexic adults and 16 controls by submitting them to a full battery of psychometric, auditory, visual and cerebellar tests. Individual data showed that all dyslexic individuals had phonological deficits, 10 individuals had auditory deficits, four had motor deficits, and two of them had visual deficits. These findings suggest that phonological deficits may occur in the absence of any other motor or sensory disorder, and may cause significant literacy impairment, as demonstrated by five of 16 dyslexic individuals.47
Dyslexia and attention deficit hyperactivity disorder
Most children with attention deficit hyperactivity disorder have difficulties in school. Learning disabilities may co-occur with developmental dyslexia.
A comparative study was carried out with children who had reading disabilities but no attention deficit hyperactivity disorder, children who only had attention deficit hyperactivity disorder, children who had reading disabilities and attention deficit hyperactivity disorder, and children without any disabilities. The auditory processing in the temporal lobe of these children was investigated. The results did not show a deficit in the auditory temporal functions in children with reading disabilities, but they suggested that the presence of attention deficit hyperactivity disorder is a relevant factor for the performance of children with reading disabilities.48 Another study conducted in Holland (Department of Special Education Vrije Universiteit Amsterdam) revealed that inhibitory deficits in lexical dyslexics might be attributed to frontocentral dysfunctions involved in motor inhibition, suggesting that there might be an association between lexical dyslexia and attention deficit hyperactivity disorder, since both groups present executive dysfunction.45
Dyslexia and low birthweight
In low birthweight infants, there exists an association between the presence of periventricular brain injury and low performance on reading and spelling tests.49 A U.S. study sought to establish an association between reading disabilities and their potential risk factors in boys and girls. The results indicated that low birthweight girls had twice the risk of developing reading disabilities.50 Differences have been found as to the use of the cortex during reading in low birthweight infants.51
Genetic influences in dyslexia
As some individuals have shown genetic susceptibility to reading disabilities, several studies have been made about dyslexias taking genetic factors into consideration. Reading has been ascribed to specific chromosomes (6, 1, 2, 15), even though there has not been any evidence so far of specific genes related to reading skills.39
Recent findings obtained from the Human Genome Project indicated four dyslexia susceptibility genes: DYX1, DYX2, DYX3 and DYX4. These genes are located in different positions, possibly showing the heterogeneity of reading disorders.52
Another study, carried out by neuropsychologist Frank Wood, from Wake Forest University, shows that other chromosomes (6, 1,2 and 15) are related to reading disabilities in some children.52 More specifically, loci on chromosomes 6 and 18 have shown replicable effects on reading skills.53
It should be underscored that the improved knowledge about the role of genetics in dyslexia may help diagnose and treat susceptible children more efficiently and rapidly.
Other written language disorders - dysgraphia and dysorthographia
Written expression (assessed through copying, dictation, and spontaneous writing) can also help detect disorders such as dysgraphia (distorted or incorrect writing) and dysorthographia (spelling disability that is unexpected for a given age or level of education). Dysgraphia and dysorthographia may be associated or not with dyslexias.
The basic principles of stimulation of written language among children are: to encourage discovery and use of logical thinking to build words and texts and represent phonemes; to provide them with opportunities to write and read spontaneously; to constantly explore different writing functions (not only production of texts, but also of letters and notes); and to show them the differences between spoken and written language. It is essential that children become aware that speech and writing are different forms of language expression.
As previously mentioned, problems with the perceptual reading processes or with psycholinguistic processes (lexical, visual, phonological, syntactic or semantic) may result in reading disabilities; in this case, the development of a rehabilitation program should be directly related to the assessment of children's deficits.35 In patients with surface dyslexia, a lexical strategy is used, and in phonological dyslexics, the most appropriate strategy consists of the letter-to-sound conversion (nonlexical).54 The stimulation of phonological awareness in pre-readers is of paramount importance, since various studies have demonstrated its efficiency in reading acquisition.55
Currently, the most recommended intervention for the treatment of children with written language disabilities is the direct approach to reading skills, combined with activities related to phonological processing. In the past, the practices sought to stimulate skills considered to be prerequisites for reading acquisition, such as visuospatial perception, psychomotor skills, etc.56
All activities that stimulate written language should be carried out in a playful way (games), so that children find pleasure in reading and writing. At home, parents should encourage their children to read by reading them stories, playing rhyming games that help with phonological awareness, playing games with letters and drawings for them to get acquainted with writing, having them read labels and ads; in brief, children should never be obliged to read a book; they should be encouraged to read it in order to know what the story is all about, instead.29
There are various causes for language disorders and learning disabilities, although many studies indicate that neurological factors might be implicated. Improved knowledge about the neurobiology of language development and learning processes will certainly contribute to a better therapeutic approach to these patients. Systematic investigation aimed at an accurate diagnosis may guide health professionals in choosing the best treatment for each case.
1. Landry SH, Smith KE, Swank PR. Environmental effects on language development in normal and high-risk child population. Semin Pediatr Neurol. 2002;9(3):192-200. [ Links ]
2. Castaño J. Bases neurobiológicas del lenguaje y sus alteraciones. Rev Neurol. 2003;36(8):781-5. [ Links ]
3. Nogueira S, Fernández B, Porfírio H, Borges L. A criança com atraso na linguagem. Saúde Infantil. 2000;22(1):5-16. [ Links ]
4. Rescorla L, Mirak J. Normal language acquisition. In: Bodensteiner JB, editor. Seminars in Pediatric Neurology. Philadelphia: W. B. Saunders Co.; 1997. p. 275-92. [ Links ]
5. Cervera-Mérida JF, Ygual-Fernández A. Intervención logopédica em los transtornos fonológicos desde el paradigma psicolingüístico del procesamiento del habla. Rev Neurol. 2003;36 Supl 1:39-53. [ Links ]
6. Costa DI, Azambuja LA, Nunes ML. Avaliação do Desenvolvimento Neuropsicomotor. In: Nunes ML, Marrone ACH. Semiologia Neurológica. Porto Alegre: EDIPUCRS; 2002. p. 351-360. [ Links ]
7. Kandel DB, Johnson JG, Bird HR, Canino G, Goodman SH, Lahey BB, et al. Psychiatric disorders associated with substance use among children and adolescents: findings from the Methods for the Epidemiology of Child and Adolescent Mental Disorders (MECA) Study. J Abnorm Child Psychol. 1997;25(2):121-32. [ Links ]
8. Casas-Fernández C. Lenguaje y epilepsia. Rev Neurol Clin. 2000;1:103-114. [ Links ]
9. Geschwind N, Galaburda AM. Cerebral Lateralization. Biological Mechanisms, Associations and Pathology. Arch Neurol. 1995:42:428-59. [ Links ]
10. Westerveld M, Sass KJ, Chelune GJ, Hermann BP, Barr WB, Loring DW, et al. Temporal lobectomy in children: cognitive outcome. Neurosurgery. 2000;92:24-30. [ Links ]
11. Caputte AJ, Accardo PJ. Language Assessment. In: Caputte AJ, Accardo PJ, editors. Developmental and Disabilities in Infancy and Childhood. Baltimore: Paul H Brookes Publishing Co.; 1991. p. 165-79. [ Links ]
12. Undheim AM. Dyslexia and psychosocial factors. a follow-up study of young Norwegian adults with a history of dyslexia in childhood. Nord J Psychiatry. 2003;57(3):221-6. [ Links ]
13. Polity E. Dificuldade de Ensinagem: Que História é Essa? Fonoaudiologia Atual. 2003;(23):60-8. [ Links ]
14. Shinnar S, Rapin I, Arnold S, Tuchman R, Shulman L, Ballanan-Gill, et al. Language regression in childhood. Pediatr Neurol. 2000;24(3):185-91. [ Links ]
15. Campos-Castelló J. Epilepsia y transtornos del lenguaje. Rev Neurol. 2000;30 Supl 1:89-94. [ Links ]
16. Stefanatos GA, Kinsbourne M, Wasserstein J. Acquired epileptiform aphasia: a dimensional view of Landau-Kleffner syndrome and the relation to regressive autistic spectrum disorders. Neuropsychol Dev Cogn Sect C Child Neuropsychol. 2002;8(3):195-228. [ Links ]
17. Wheless JW, Simos PG, Butler IJ. Language dysfunction in epileptic conditions. Semin Pediatr Neurol. 2002;9(3):218-28. [ Links ]
18. Ribeiro KMN, Assumpção FB, Valente KDR. Síndrome de Landau-Kleffner e regressão autística. Arq Neuro-Psiquiatr. 2002;60(3-B):835-9. [ Links ]
19. Tuchman R, Rapin I. Epilepsy in autism. Lancet Neurol. 2002;1(6):352-8. [ Links ]
20. Palmini A, Da Costa JC, Paglioli-Neto E, Portuguez M, Martinez JV, Paglioli E, et al. Reversible and irreversible autistic regression related to epilepsy and epileptiform EEG discharges: physiopatogenic considerations and preliminary report of 5 cases. J Epilepsy Clin Neurophysiol. 2002;8(4):221-8. [ Links ]
21. Rapin I, Dunn M. Update on language disorders of individuals on the autistic spectrum. Brain Dev. 2003;25(3):166-72. [ Links ]
22. Botting N, Conti-Ramsden G. Autism, primary pragmatic difficulties, and specific language impairment: can we distinguish them using psycholinguistic markers? Dev Med Child Neurol. 2003;45(8):515-24. [ Links ]
23. Wilson S, Djukic A, Shinnar S, Dharmani C, Rapin I. Clinical characteristics of language regression in children. Dev Med Child Neurol. 2003;45(8):508-14. [ Links ]
24. Becker F. Modelos Pedagógicos e Modelos Epistemológicos. In: Silva LH, Azevedo CJ. Paixão de aprender II. Petrópolis, RJ: Vozes; 1995. [ Links ]
25. Tedesco MRM. Diagnóstico e terapia dos distúrbios do aprendizado da leitura e escrita. In: Otalilio LP. Tratado de Fonoaudiologia. São Paulo: Roca; 1997. [ Links ]
26. Shaywitz SE, Shaywitz BA. Dyslexia (specific reading disability). Pediatr Rev. 2003;24(5):147-53. [ Links ]
27. Shaywitz SE. Dyslexia. New Engl J Med. 1998;338(5):307-12. [ Links ]
28. Mansur LL, Senaha MLH. Distúrbios de linguagem oral e escrita e hemisfério esquerdo. In: Nitrini R, Caramelli P, Mansur LL. Neuropsicologia: das bases anatômicas à reabilitação. São Paulo: Clínica Neurológica do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; 1996. [ Links ]
29. Capellini AS, Poleti FS, Renzo, Arruda PD, Pieroni R, Miurd RY, et al. Formação de interlocutores para a construção da linguagem escrita: manual de orientação a pais e professores de crianças com dificuldades escolares. Temas sobre Desenvolvimento 2000;9(50):33-9. [ Links ]
30. Démont E. Consciência fonológica, consciência sintática: que papel (ou papéis) desempenha na linguagem eficaz da leitura. In: Gregóire J, Piérart B. Avaliação dos problemas de leitura: os novos modelos teóricos e suas implicações diagnósticas. Porto Alegre: Artes Médicas; 1997. [ Links ]
31. Heim S, Eulitz C, Elbert T. Altered hemispheric asymmetry of auditory P100m in dyslexia. Eur J Neurosci. 2003;17(8):1715-22. [ Links ]
32. Lozano A, Ramirez M, Ostrosky-Solis F. The neurobiology of developmental dyslexia: a survey. Rev Neurol. 2003;36(11):1077-82. [ Links ]
33. Medow N, Olitsky SE, De Respinis P. Learning disorders. J Pediatr Ophthalmol Strabismus. 2003;40(2):92-4. [ Links ]
34. Hayes EA, Warrier CM, Nicol TG, Zecker SG, Kraus N. Neural plasticity following auditory training in children with learning problems. Clin Neurophysiol. 2003;114(4):673-84. [ Links ]
35. Garcia JN. Manual de Dificuldades de Aprendizagem. Porto Alegre: Artes Médicas, 1998. [ Links ]
36. Nunes T, Buarque L, Bryant P. Dificuldade na aprendizagem da leitura: teoria e prática. São Paulo: Cortez; 1997. [ Links ]
37. Spreen O, Risser AH, Edgel D. Developmental Neuropsychology. New York: Oxford University. Press; 1995. [ Links ]
38. Ciasca AS. Distúrbios e dificuldades de aprendizagem: diagnóstico através de bateria lúria nebraska para crianças - BLN-C. In: Damasceno BP, Coutry MI. Temas em Neuropsicologia e Neurolingüística. São Paulo: Tec Art; 1995. [ Links ]
39. Rutkowski JS, Grewther DP, Grewther SG. Change detection is impaired in children with dyslexia. J Vis. 2003;3(1):95-105. [ Links ]
40. Mathes PG, Denton CA. The prevention and identification of reading disability. Semin Pediatr Neurol. 2002;9(3):185-91. [ Links ]
41. Pinheiro AMV. Dificuldades específicas de leitura: a identificação de déficits cognitivos e a abordagem do processamento de informação. Psicologia: Teoria e Pesquisa. 1995;11(2):107-15. [ Links ]
42. McCandliss BD, Noble KG. The development of reading impairment: a cognitive neuroscience model. Ment Retard Dev Disabil Res Rev. 2003;9(3):196-204. [ Links ]
43. Landry SH, Smith KE, Swank PR. Environmental effects on language development in normal and high-risk child population. Semin Pediatr Neurol. 2002;9(3):192-200. [ Links ]
44. van der Schoot M, Licht R, Horsley TM, Sergeant JA. Fronto-central dysfunction in reading disability depend on subtype: guessers but not spellers. Dev Neuropsychol. 2002;22(3):533-64. [ Links ]
45. Facoetti A, Lorusso ML, Paganoni P, Cattaneo C, Galli R, Umilta C, et al. Auditory and visual automatic attention deficits in developmental dyslexia. Brain Res Cogn Brain Res. 2003;16(2):185-91. [ Links ]
46. Ramus F, Rosen S, Dakin SC, Day BL, Castellote JM, White S, et al. Theories of developmental dyslexia: insights from a multiple case study of dyslexic adults. Brain. 2003;126(Pt 4):841-65. [ Links ]
47. Breier JI, Fletcher JM, Foorman BR, Klaas P, Gray LC. Auditory temporal processing in children with specific reading disability with and without attention deficit/hiperactivity disorder. J Speech Lang Hear Res. 2003;46(1):31-42. [ Links ]
48. Downie AL, Jakobson LS, Frisk V, Ushycky I. Periventricular brain injury, visual motion processing, and reading and spelling abilities in children who were extremely low birthweight. J Int Neuropsychol Soc. 2003;9(3):440-9. [ Links ]
49. St Sauver JL, Katusic SK, Barbaresi WJ, Colligan RC, Jacobsen SJ. Boy/girl differences in risk for reading disability: potential clues? Am J Epidemiology. 2001;154(9):787-94. [ Links ]
50. Khan SC, Frisk V, Taylor MJ. Neurophysiological measures of reading difficulty in very-low-birthweight children. Psychophysiology. 1999;36(1):76-85. [ Links ]
51. van Hout A. Orientações neurológicas e neuropsicológicas: reeducação dos erros e dos distúrbios cognitivos. In: van Hout A, Estienne F. Dislexias: Descrição, Avaliação, Explicação e Tratamento. Porto Alegre: Artes Médicas; 2001. [ Links ]
52. Pedagogia em Foco [site na Internet]. Fortaleza: Pedagogia em Foco; c1998-2004 [atualizado em 06/01/2003; citado em 05/12/2003] Martins V. Dislexia e o projeto genoma humano; [aproximadamente 3 telas]. Disponível em: http://www.pedagogiaemfoco.pro.br/spdlx05.htm. [ Links ]
53. Francks C, MacPhie IL, Monaco AP. The genetic basis of dyslexia. Lancet Neurol. 2002;1(8):483-90. [ Links ]
54. Byrne B, Fielding-Barnsley R. Phonetic awareness and letter knowledge in the child's acquisition of the alphabetic principle. J Educ Psychol. 1989;81:313-21. [ Links ]
55. Capovilla AGS, Capovilla FC. Efeitos do treino de consciência fonológica em crianças de baixo nível sócio-econômico. Psicologia: Reflexão e Crítica. 2000;13(1):7-24. [ Links ]
56. Salles JF, Parente MA, Machado SS. As dislexias de desenvolvimento: aspectos neuropsicológicos e cognitivos. Revista Interações - Universidade de São Marcos, São Paulo/SP. No Prelo 2003. [ Links ]
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