Print version ISSN 0034-7094
Rev. Bras. Anestesiol. vol.59 no.4 Campinas July/Aug. 2009
Correlation between the inspired fraction of oxygen, maternal partial oxygen pressure, and fetal partial oxygen pressure during cesarean section of normal pregnancies*
Correlación entre la fracción inspirada de oxígeno, la presión parcial de oxígeno materno y la presión parcial de oxígeno fetal durante el parto por cesárea en embarazos normales
Carlos Henrique Viana de Castro, TSA, M.D.I; Marcos Guilherme Cunha Cruvinel, TSA, M.D.II; Fabiano Soares Carneiro, TSA, M.D.III; Yerkes Pereira Silva, M.D.IV; Antônio Carlos Vieira Cabral, M.D.V; Roberto Cardoso Bessa, TSA, M.D.III
Mestre em Medicina; Diretor Técnico do Hospital Lifecenter
IIAnestesiologista do Hospital Lifecenter; Especialista em Clínica Médica; Certificado de Atuação em Dor
IIIAnestesiologista do Hospital Lifecenter e do Hospital das Clínicas MG
IVAnestesiologista do Hospital Lifecenter; Mestre e Doutor em Medicina pela UFMG
VDoutor em Medicina; Professor Titular do Departamento de Ginecologia e Obstetrícia da UFMG
OBJECTIVES: Despite changes in pulmonary function, maternal oxygenation
is maintained during obstetric regional blocks. But in those situations, the
administration of supplementary oxygen to parturients is a common practice.
Good fetal oxygenation is the main justification; however, this has not been
proven. The objective of this randomized, prospective study was to test the
hypothesis of whether maternal hyperoxia is correlated with an increase in fetal
gasometric parameters in elective cesarean sections.
METHODS: Arterial blood gases of 20 parturients undergoing spinal block with different inspired fractions of oxygen were evaluated and correlated with fetal arterial blood gases.
RESULTS: An increase in maternal inspired fraction of oxygen did not show any correlation with an increase of fetal partial oxygen pressure.
CONCLUSIONS: Induction of maternal hyperoxia by the administration of supplementary oxygen did not increase fetal partial oxygen pressure. Fetal gasometric parameters did not change even when maternal parameters changed, induced by hyperoxia, during cesarean section under spinal block.
Keywords: PHYSIOLOGY, Oxygen transport, Fetal oxygenation; SURGERY, Obstetric: cesarean section
Y OBJETIVOS: A pesar de las alteraciones en la función pulmonar,
la oxigenación materna se mantiene en las anestesias regionales para
obstetricia. Pero incluso así, en esas situaciones, el suministro de
oxígeno suplementario para la madre se practica en forma diseminada.
La principal justificación es la buena oxigenación fetal, sin
embargo, no existe la debida comprobación al respecto. Este estudio prospectivo
y con distribución randómica de las pacientes, tuvo el objetivo
de comprobar la hipótesis de la existencia o no de una correlación
entre la hiperoxia materna y la elevación de los parámetros gasométricos
fetales en la cesárea por elección.
MÉTODO: Se estudiaron veinte pacientes embarazadas, sometidas a la raquianestesia, a través de gasometrías arteriales, con diferentes fracciones inspiradas de oxígeno y correlacionadas con la gasometría fetal.
RESULTADOS: El aumento de la fracción inspirada de oxígeno materno no se correlacionó con el aumento de la presión parcial de oxígeno fetal.
CONCLUSIONES: La inducción de hiperoxia materna a través de la oxigenoterapia suplementaria, no fue capaz de aumentar la presión parcial de oxígeno en el feto. No hubo modificación en los parámetros gasométricos fetales, incluso en el caso del cambio de esos parámetros en la parturiente, inducidos por la hiperoxia durante la cesárea bajo raquianestesia.
The use of supplementary oxygen in general anesthesia became routine in the decade of 1960 1. Despite the changes in pulmonary function seen in regional blocks (epidural and subarachnoid) used in obstetrics, maternal oxygenation is maintained and a rational explanation to administer supplementary oxygen to the mother has not been established 2-5. In 1984, Crawford in his textbook stated that it is recommendable to administer supplementary oxygen to the parturient, and this recommendation was disseminated in clinical practice mainly for reasons related to the fetus, but without being properly proved6. The objective of this study was to analyze whether maternal hyperoxia generated by high oxygen inspired fraction is capable of increasing fetal partial oxygen pressure during cesarean section of normal pregnancies.
After approval by the Ethics on Research Committee and signing of the informed consent, 20 parturients at term (38 to 41 weeks), scheduled for cesarean section participated in this randomized, prospective study. Patients were divided in two groups: study (group 1), composed of 12 parturients who underwent intraoperative hyperoxia; and control (group 2), composed of eight parturients who underwent cesarean section without supplementary oxygen
Table I shows the distribution by age, gestational age, and number of pregnancies of the studied patients. Exclusion criteria were as follows:
- Maternal disease with repercussions in fetal oxygenation (preeclampsia, hypertension, pulmonary disease, cardiac disease with shunt, and diabetes mellitus types 1 and 2).
- Presence of intraoperative intercurrences that compromised fetal oxygenation (hypertension not compensated by the therapeutic maneuvers described, fetal extraction time > 3 minutes).
Patients were admitted to the operating room without pre-anesthetic medication, monitored with electrocardiogram (ECG), peripheral oxygen saturation (SpO2), non-invasive blood pressure (NIBP) with one-minute intervals until delivery followed by measurements every three minutes until the end of the procedure. An 18G catheter was used for venoclysis in an upper limb. Patients were hydrated with Ringer's lactate warmed to 37° C administered rapidly at 15 mL.kg-1 before the anesthetic blockade. After antisepsis (according to the recommendations of the Hospital Infection Control Commission (CCIH, from the Portuguese), the skin was infiltrated with 2% lidocaine, followed by puncture of the subarachnoid space with a pencil tip 27G needle with the patient in the sitting position. This was followed by the subarachnoid administration of 0.5% heavy bupivacaine 10 mg, associated with 60 μg of morphine. After the regional block, patients were placed in dorsal decubitus and the uterus was moved manually to the left. Hypotension was defined as a reduction in blood pressure greater than 20% from control levels or lower than 100 mmHg. Hypotension was treated with boluses of 5 to 10 mg of ephedrine until it reached normal levels. Reductions in SpO2 below 92% were treated immediately with supplementary oxygen and the patient was removed from the study. Dexamethasone 8 mg, was administered before anesthesia to prevent nausea and vomiting. Nausea and vomiting were treated with metochlopramide 10 mg, after hypotension was ruled out.
Blood samples were collected from the umbilical cord before placental expulsion and before the onset of neonatal respiratory movements. The umbilical cord was clamped proximal and distally, and the umbilical vein was punctured to collect blood samples. Maternal arterial blood gases were measured twice: before the administration of oxygen or compressed air and 10 minutes after the administration of oxygen or compressed air. Blood samples were packed in ice and sent immediately to the laboratory. The syringes contained enough heparin to fill the dead space of the syringe. The following parameters were measured in all blood samples: pH, PaO2, CO2, and bicarbonate.
Two groups of patients were investigated: one (study) received supplementary oxygen using an inspired oxygen fraction (FiO2) equal or greater than 0.6; the other group (control) received room air, i.e., a FiO2 of 0.21. The FiO2 to be administered was determined randomly using a table sealed in an envelope. It was determined by the mixer of the anesthesia device and the reading was confirmed by the oximeter of the anesthesia equipment 7. Oxygen was delivered through a mask with reservoir.
The Kruskal-Wallis test was used to compare age, pre- and postoperative PaO2, fetal PaO2, and PaO2 ratio (Post-PaO2/pre-PaO2 x 100) between both groups. This non-parametric test compares two or more independent samples (in this case, use of oxygen or not) in relation to a parameter of interest that is at least ordinal. The non-parametric test Wilcoxon was used to compare pre- and postoperative PaO2 in each group (use of oxygen or not). Due to the difficulty to undertake the study, which is reflected in the small number of patients, it was decided to use non-parametric tests since the confirmation of normalcy of the data can be hindered by the small number of study patients. Besides, Spearmen test (non-parametric) was used to assess the relationship among parameters of interest. Results were considered significant at the 5% level (p < 0.05).
Table II shows the statistically significant difference (p < 0.05) in post-PaO2 and PaO2 ratio (%) between the group that used oxygen and the group that did not use oxygen. In both cases, the PaO2 of patients who used oxygen was significantly higher than that of the patients who did not use oxygen. Note that the age of the patients did not differ significantly. A significant difference (p < 0.05) was observed when pre- and postoperative PaO2 among patients who used oxygen were compared, in which postoperative PaO2 was significantly higher than preoperative measurements. However, pre- and postoperative PaO2 did not show significant differences (p > 0.05) among patients who did not receive oxygen. As can be seen in table IV, maternal and fetal PaO2 did not show significant differences, regardless of whether or not oxygen was used; therefore, maternal PaO2 did not determine fetal PaO2. One patient in the study group developed post-dura mater puncture headache.
During the decade of 1960, the use of supplementary oxygen became routine in general anesthesia 1. In obstetric regional blocks (epidural and subarachnoid), maternal oxygenation is maintained despite changes in pulmonary function; a rational justification to administer supplementary oxygen to the mother has not been established. In 1984, Crawford, in his text book, stated that the administration of supplementary oxygen to the mother is recommendable mainly for fetal reasons, but without supportive evidence6. Marx and Mateo 8 demonstrated the relationship between maternal and fetal oxygen pressure (PaO2) in general anesthesia. Analysis of the present study was hindered since hypoxic parturients were included8. Ramanathan et al. 9 repeated in essence the work of Marx and Mateo, but patients received epidural anesthesia and hypoxic women were excluded. There was a correlation between maternal and fetal PaO2, but fetal Apgar and pH did not show differences. At first, those results seem to indicate that the administration of supplementary O2 to the mother is rational; however, the difference observed was not statistically significant.
Therefore, it is adequate to ask: if maternal hyperoxia does not induce favorable changes in the fetus, can it be harmful? The possibility that maternal hyperoxia can close the ductus arteriosus, which could affect the fetal circulation and the first moments of life, is one of the established concerns. Clinical experience shows that this is a theoretical risk that is ignored in clinical practice. Khaw et al. 10 undertook a study with women undergoing elective cesarean section under subarachnoid block randomly divided in two groups: one in room air and the other with supplementary O2. They analyzed maternal and fetal arterial blood gases and fetal markers of free radicals. The results showed a clear difference between both groups; the levels of free radical were higher in the women who received supplementary oxygen. This imposes a new question: the increased activity of free radical markers is a marker for fetal morbidity?
Current knowledge does not allow the correlation between the activity of free radicals to an increase in fetal morbidity in parturients undergoing elective cesarean section. Khaw et al. 10 stated that in low risk situations (for example, elective cesarean section) a favorable result would not, probably, be influenced negatively by maternal hyperoxia. However, this report could influence premature fetuses or those with some degree of distress. Recent studies reported better results in newborns resuscitated with room air when compared to those treated with oxygen 11,12. Those results have had a considerable influence on clinical practice and therefore the manual of neonatal resuscitation revoked the recommendation to administer oxygen.
Will the present study and the ones mentioned above change obstetric anesthesiology regarding the administration of supplementary oxygen? Justifying the administration of supplementary oxygen to parturients with the following statements might change: a) the oxygen is for the fetus; b) if supplementary oxygen does not improve, at least it is not harmful: c) oxygen is for severely ill patients. This study showed that supplementary oxygen did not bring any benefits in the situations mentioned, since it did not cross into the fetal blood. Although the use of oxygen in critical situations for the fetus and mother is almost a conditioned reflex of anesthesiologists, this behavior is weakened by recent evidence that the excessive use of oxygen might be associated with some damage, especially in fetal distress.
The waist of resources is another important aspect that might be brought into the discussion. Chart I shows the number of abdominal deliveries in 2001 and 2002 (DATASUS, 2004). If a cesarean section lasts a mean of one hour and the price of oxygen varies from approximately US$2.37* to US$5.39* per hour, one can infer that by not using oxygen, one would decrease costs by US$2,820,000.00 to US$6,350,000.00. If we add the nasal catheter, the yearly cost would be decreased by US$3,200,000.00 to US$6,700,000.00. A developing country cannot ignore those sums. Oxygen prices were furnished by the pharmacy of a hospital in Belo Horizonte and refer to the maximal and minimal prices for the public health system in 2005.
Finally, we should try to understand why fetal oxygen did not increase despite the elevation in maternal PaO2. Similarly to the present study, Kelly et al. 5 and Cogliano et al. 13 administered 35% and 40% oxygen, respectively, and it did not increase oxygen concentration in fetal blood. The authors concluded that this lack of fetal repercussion might be due to an intraplacental arteriovenous shunt, which might be responsible for not using the additional oxygen offered by the mother to the intervillous space, resulting in the return of excess oxygen to the maternal blood circulation. This hypothesis is supported by the study of Schaaps 14 in which the level of maternal PaO2 was 93 mmHg, while that of the fetus was 19 mmHg in the umbilical vein, which is significantly lower than that of the intervillous space (29.2 mmHg).
Summarizing, one can state that induction of maternal hyperoxia by using supplementary oxygen is not capable of increasing fetal partial oxygen pressure and that fetal gasometric parameters do not change, even when those parameters change in the mother induced by maternal hyperoxia in cesarean sections under subarachnoid block.
The present study has important limitations. Using procedures such as arterial puncture and collecting umbilical cord blood make parturients insecure, hence the reduced number of patients and its impact on the statistical analysis. Therefore, the lack of an impact of maternal hyperoxia in fetal oxygenation, along with the economy of resources identified, justify further studies with a larger study population.
01. Nunn JF - Elastic Forces and Lung Volumes, In: Nunn JF - Nunn's Applied Respiratory Physiology. 4ed, Oxford, Butterworth Heinemann 1993;53-68. [ Links ]
02. Steinbrook RA - Respiratory effects of spinal anesthesia. Int Anesthesiol Clin 1989;27:40-45. [ Links ]
03. Pitkanen MT - Body mass and spread of spinal anesthesia with bupivacaine. Anesth Analg 1987;66:127-131. [ Links ]
04. Gogarten W - Spinal anaesthesia for obstetric. Best Pract Res Clin Anaesthesiol 2003;17:377-392. [ Links ]
05. Kelly MC, Fitzpatrick KT, Hill DA - Respiratory effects of spinal anaesthesia for cesarian section. Anaesthesia 1996;51:1120-1122. [ Links ]
06. Crawford JS - Principles and Practice of Obstetric Edinburg (UK): Anaesthesia, 5th Ed, Oxford, Blackwell Scientific Publications, 1984. [ Links ]
07. Stone AG, Howell PR - Use of the common gas outlet for the administration of supplemental oxygen during Caesarean section under regional anaesthesia. Anaesthesia 2002;57:690-692. [ Links ]
08. Marx GF, Mateo CV - Effects of different oxygen concentrations during general anaesthesia for elective caesarian section. Can Anaesth Soc J 1971;18:587-593. [ Links ]
09. Ramanathan S, Gandhi S, Arismendy J et al. - Oxygen transfer from mother to fetus during cesarian section under epidural anesthesia. Anesth Analg 1982;61:576-581. [ Links ]
10. Khaw KS, Wang CC, Ngan Kee WD et al. - Effects of high inspired oxygen fraction during elective caesarean section under spinal anaesthesia on maternal and fetal oxygenation and lipid-peroxidation. Br J Anaesth 2002;88:18-23. [ Links ]
11. Saugstad OD, Rootwelt T, Aalen O - Resuscitation of asphyxiated newborn infants with room air or oxygen: an international controlled trial: the Resair 2 study. Pediatrics 1998;102:e1. [ Links ]
12. Saugstad OD, Ramji S, Vento M - Resuscitation of depressed newborn infants with ambient air or pure oxygen: a meta-analysis. Biol Neonate 2005;87:27-34. [ Links ]
13. Cogliano MS, Graham AC, Clark VA - Supplementary oxygen administration for elective Caesaeran section under spinal anaesthesia. Anaesthesia 2002;57:66-69. [ Links ]
14. Schaaps JP, Tsatsaris V, Goffin F et al. - Shunting the intervillous space: new concepts in human uteroplacental vascularization. Am J Obstet Gynecol 2005;192:323-332. [ Links ]
Correspondence to: Submitted em 05
de abril de 2008 *
Received from Hospital Lifecenter
Dr. Carlos Henrique Viana de Castro
Rua do Mosteiro, 37/701 Vila Paris
30380 Belo Horizonte, MG
Accepted para publicação em 17 de março de 2009
Submitted em 05
de abril de 2008
* Received from Hospital Lifecenter