Drogas citostáticas: medidas para minimização do risco ocupacional

Barbosa, Anadergh

doi:10.1590/S0034-71671988000100008

Resumos

As drogas citostáticas são substâncias citotóxicas destinadas a causar disfunsão celular. Seu mecanismo de ação envolve interação com DNA, RNA na síntese proteica de células vivas, normais ou cancerosas. São também atribuídos a elas um potencial para mutagenicidade, carcinogenicidade, assim como efeitos teratogênicos. Alguns trabalhadores hospitalares estão potencialmente expostos a essas drogas. Propõe-se recomendações para minimizar os riscos ocupacionais causados pelas mesmas, apresentando algumas medidas de controle relativamente simples, de forma a adequarem-se à realidade da maioria dos hospitais brasileiros.

The cytostatic drugs are cytostatoxic substances and designed to cause cell dysfunction. Their mechanism of action involves interaction with DNA, RNA on protein synthesis in living cells, normal or cancerous. Though these actions the potencial for mutagenic, carcinogenic or teratogenic effects are possible. Some people who work in hospital are frequentely exposed to these drugs. Recomended have done to minimized the occupational risks that produced by then, some forms to control a little simple are showed to adapt to reality of the majority of Brasilian hospital.

Drogas citostáticas: medidas para minimização do risco ocupacional^* * Trabalho apresentado no III Encontro Nacional de Enfermeiros do Trabalho - São Paulo - SP

Anadergh Barbosa

Enfermeira do CEDRHUS - Divisão de Segurança, Higiene e Medicina do Trabalho - FHDF

RESUMO

As drogas citostáticas são substâncias citotóxicas destinadas a causar disfunsão celular. Seu mecanismo de ação envolve interação com DNA, RNA na síntese proteica de células vivas, normais ou cancerosas. São também atribuídos a elas um potencial para mutagenicidade, carcinogenicidade, assim como efeitos teratogênicos. Alguns trabalhadores hospitalares estão potencialmente expostos a essas drogas. Propõe-se recomendações para minimizar os riscos ocupacionais causados pelas mesmas, apresentando algumas medidas de controle relativamente simples, de forma a adequarem-se à realidade da maioria dos hospitais brasileiros.

ABSTRACT

The cytostatic drugs are cytostatoxic substances and designed to cause cell dysfunction. Their mechanism of action involves interaction with DNA, RNA on protein synthesis in living cells, normal or cancerous. Though these actions the potencial for mutagenic, carcinogenic or teratogenic effects are possible. Some people who work in hospital are frequentely exposed to these drugs. Recomended have done to minimized the occupational risks that produced by then, some forms to control a little simple are showed to adapt to reality of the majority of Brasilian hospital.

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^Anexo Anexo

1. DAVIS, R.M. Guidelines for safe handling of cytotoxic drugs in pharmacy departaments and hospital wards. Hospital Pharmacy, 16: 17-20, jan. 1981
2. FALCK, K. et alii. Mutagenicity of urine of nurses handling cytostatic drugs. Lancet, 1979 p. 1250-1.
3. HARRISON, B.R. Developing guidelines for working with antineoplastic drugs. American Journal Hospital Pharmacy 38: 1686-93, 1981
4. HOFFMAN, D.M. The handling of antineoplastic drugs in a major cancer center. Hospital Pharmacy, 15: 302-04, June 1980
5. NEAL, A de W. et alii. Exposure of Hospital worders to Airborne Antineoplastic Agents. American Journal of Hospital Pharmacy. 40: 587-601, 1983
6. NIKULA, E. et alii. Chromossome aberrations in lymphocytes of nurses handling cytostatic agents, scand J. work ENVIRON HEALTH. 10: 71-4. 1984
7. NORFA, H et alii. Increased sister chromatid exchange frequencies in limphocytes of nurses handling cytostatic drugs. Scand J. work Environ health. 6: 299-301. 1980
8. SIEBER, S.M. & ADAMSON, R. H. Toxicity of Antineoplastic agents in man; Chromossomal Aberrations, anfertility effects, congenital malformations, and carcinogenic potencial. Adv cancer res., 22: 57-155, 1975
9. TORTORICI, M.R Precautions followed by personnel involved with the preparation of parenteral antineoplastic medications. Hospital Pharmacy. 15: 293-301 June. 1980
10. VAINIO, H. Inhalation anesthetics, anticancer drugs and sterilants as chemical hazards in hospitals. Scand J. Environ Health. 8: 94-107. 1982
11. VAUGHN, M. C. & CHRISTENSEN. Occupational exposure to cancer chemotherapeutic drugs: A literature review. American Industrial Hygiene Association. 46, June 1985.

Anexo

*

Trabalho apresentado no III Encontro Nacional de Enfermeiros do Trabalho - São Paulo - SP

Datas de Publicação

Publicação nesta coleção
02 Mar 2015
Data do Fascículo
Mar 1988

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. DAVIS, R.M. Guidelines for safe handling of cytotoxic drugs in pharmacy departaments and hospital wards. Hospital Pharmacy, 16: 17-20, jan. 1981

[2] 2. FALCK, K. et alii. Mutagenicity of urine of nurses handling cytostatic drugs. Lancet, 1979 p. 1250-1.

[3] 3. HARRISON, B.R. Developing guidelines for working with antineoplastic drugs. American Journal Hospital Pharmacy 38: 1686-93, 1981

[4] 4. HOFFMAN, D.M. The handling of antineoplastic drugs in a major cancer center. Hospital Pharmacy, 15: 302-04, June 1980

[5] 5. NEAL, A de W. et alii. Exposure of Hospital worders to Airborne Antineoplastic Agents. American Journal of Hospital Pharmacy. 40: 587-601, 1983

[6] 6. NIKULA, E. et alii. Chromossome aberrations in lymphocytes of nurses handling cytostatic agents, scand J. work ENVIRON HEALTH. 10: 71-4. 1984

[7] 7. NORFA, H et alii. Increased sister chromatid exchange frequencies in limphocytes of nurses handling cytostatic drugs. Scand J. work Environ health. 6: 299-301. 1980

[8] 8. SIEBER, S.M. & ADAMSON, R. H. Toxicity of Antineoplastic agents in man; Chromossomal Aberrations, anfertility effects, congenital malformations, and carcinogenic potencial. Adv cancer res., 22: 57-155, 1975

[9] 9. TORTORICI, M.R Precautions followed by personnel involved with the preparation of parenteral antineoplastic medications. Hospital Pharmacy. 15: 293-301 June. 1980

[10] 10. VAINIO, H. Inhalation anesthetics, anticancer drugs and sterilants as chemical hazards in hospitals. Scand J. Environ Health. 8: 94-107. 1982

[11] 11. VAUGHN, M. C. & CHRISTENSEN. Occupational exposure to cancer chemotherapeutic drugs: A literature review. American Industrial Hygiene Association. 46, June 1985.