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On-line version ISSN 1518-8787
Rev. Saúde Pública vol.34 n.4 São Paulo Aug. 2000
Psychiatric assessment in transplantation
Avaliação psiquiátrica no transplante
Erick Messiasa and Christine E Skotzkob
aDepartment of Psychiatry, University of Maryland. Baltimore, MD, USA. bDepartment of Psychiatry, University of Medicine and Dentistry of New Jersey, Robert Wood Jonhson Medical System. New Bruswick, NJ, USA
Organ transplantation, psychology#. Patient selection#. Psychiatry#. Physician's role#. Interview, psychological. Patient care team. Mental disorders. Patient compliance. ¾ Psychiatric assessment. Consultation liaison psychiatry.
The implementation of the presumptive donor law in Brazil is expected to increase the availability of organs for transplantation. As medical management of end-stage organ dysfunction continues to improve, increasing numbers of potential transplant recipients will be available to meet this supply. There is mounting evidence that supports the involvement of skilled psychiatric practitioners in the selection of transplant candidates. Data supporting the influence of psychosocial factors on compliance and therefore medical outcomes continues to grow. The literature review allows delineating the components and rationale for comprehensive psychosocial evaluations as a component of preoperative transplantation evaluation.
Transplante de órgãos, psicologia#. Seleção de pacientes#. Psiquiatria#. Papel do médico#. Entrevista psicológica. Equipe de assistência ao paciente. Transtornos mentais. Cooperação do paciente. ¾ Avaliação psicossocial. Psiquiatria de ligação.
A implementação da figura do doador presumido e as recentes mudanças na regulamentação do transplante no Brasil irão aumentar a disponibilidade de órgãos no País. O avanço no cuidado de doentes portadores de insuficiência grave de órgãos, por sua vez, irá aumentar a demanda por esses mesmos órgãos. Há considerável literatura apoiando o envolvimento de psiquiatras no processo de seleção dos candidatos ao transplante. Pesquisas mostram que fatores psicossociais influenciam na adesão ao tratamento e, conseqüentemente, no prognóstico desses pacientes. A partir de uma revisão da literatura existente, articula-se os componentes e lógicas de uma avaliação psicossocial abrangente, propondo sua inserção na avaliação pré-operatória dos pacientes para o recebimento de órgão.
Brazil's reintegration of psychiatric and medical services in the general hospital has been reviewed in recent years.7 Programs such as solid organ transplantation, where costly scarce resources are provided to a limited number of recipients represent a particular area where psychiatric involvement could be exceedingly valuable.
The recent implementation of the presumptive donor law is expected to increase the availability of organs for transplantation in Brazil. The number of patients in need of transplantation will likely also grow along with the problems inherent in individuals with chronic medical conditions. The proposal is that transplant programs develop interdisciplinary teams to participate in the selection of patients who will be compliant with life sustaining treatment after transplantation.
The importance of psychosocial involvement in candidate selection is generally recognized in transplantation programs in the United States and elsewhere.34 Earlier surveys27,34 documented that 100% of responding liver transplant programs and high percentages of other organ transplant programs use psychosocial assessments as a component of candidate selection criteria.
Ongoing psychiatric involvement in transplant programs is supported by the high rates of psychiatric co-morbidity seen in individuals with end-stage organ dysfunction. Rates of depression range from a point prevalence of 20%18 to 45%38 in heart disease patients. Craven9 examined a consecutive series of applicants for lung transplantation and found that 50% reported a history of psychiatric disorder. Trzepacz et al49 found that 20% of liver transplant candidates had concomitant adjustment disorders and 4.5% had major depression; 9% met the criteria for alcohol abuse or alcohol dependence, and 2% met criteria for abuse of other substances. Of patients undergoing dialysis, major depression has been described in as few as 5%42 and as many as 22%.31 Rundell's37 work demonstrated that individuals seen in a transplant setting differ from those seen in general hospitals and are more likely to have psychiatric issues.
A growing body of literature links significant neuropsychiatric side effects to cyclosporine, tacrolimus, and other elements of the transplant regimen.1,3,4,6,10-13,16,17,21,24-26,30,35,43,47-48,51-54 These effects are often more pronounced in individuals who have demonstrated preoperative difficulties.
Potential roles for a mental health team lead by psychiatry in a transplantation program are listed in Table 1. The present article is meant to highlight the psychiatric aspects in the assessment of candidates for transplantation, and articulate a framework for the performance of such an evaluation. Many of these areas are supported by Freeman et al20 who previously delineated the potential roles for a psychiatrist on a transplantation team.
The role of a comprehensive psychosocial evaluation in transplantation selection is to define an individual's risk factors for having difficulty in the post-operative period while recognizing their strengths. A detailed psychiatric assessment (Table 2) is generally completed after the initial medical screening and prior to the completion of all necessary physiologic testing for the transplantation. There is increasing evidence that psychosocial factors are associated with post-transplantation noncompliance and morbidity. Substance abuse history, personality disorder, and global psychosocial risks were associated with compliance problems.14,19,39-40 There is also evidence documenting that the number of rejection episodes after cardiac transplantation were linked to global psychosocial risks.8 Experienced psychiatric practitioners are able to identify individuals who are at an increased risk of having compliance difficulties over time, and alert the team about the steps to be taken to minimize this risk.
Assessment of compliance should include attention to patterns of adherence to appointments, medications, and medical advice, especially regarding the individual's ability to cease harmful habits such as nicotine and alcohol use. Additionally, the ability to incorporate dietary and exercise advice should be included here. Adopting a new diet or exercise habits are extremely difficult and speaks to the patient's motivation to adapt themselves to the rigors of transplantation.
In the pre-transplant period, one should also address the individual's understanding of the importance of strict adherence to a treatment plan as a way to maximize their survival in the post transplant period by keeping their "new" organ safe. Detailed review of the neuropsychiatric and general physical external effects of immunosuppressive medications should be mentioned to allow support and further explanation, if requested. The ability of a candidate to acknowledge and appreciate the potential for a negative impact of transplantation translates into their ability to incorporate the full spectrum of possibilities in the post transplant period.
The ability to acknowledge potential positive and negative aspects of transplantation is an essential component of competence. The need to assess competence arises in all procedures that involve risks, and transplant surgery is not an exception. To be competent to accept the procedure the patient needs to understand the medical need for such a procedure, the risks involved, the alternatives, and the risks involved in rejecting the procedure. Overall, medically ill patients do not show an increased risk of being unable of giving consent to the treatment.2 However, the severity of the conditions requiring transplantation make the likelihood of disorders with consciousness impairment greater and therefore make the assessment of competence crucial. Table 3 lists factors, which potentially make an individual unable to render competent judgements. When subtle questions concerning cognitive status arise the clinician should obtain neuropsychological testing if the patient is stable enough to complete them.23
Psychiatric co-morbidity is another area that should be addressed in a complete assessment. There is no clear decision algorithm on how to weight the impact of mental illness in candidates for transplantation. The assessment of these patients is important and they should be given a comprehensive treatment plan aimed at modifying remediable problems. The individual's willingness and ability to attend to these issues and their ultimate ability to be compliant with treatment protocols should be the ultimate deciding factors in candidate listing decisions.
The literature shows mixed results in transplanting individuals with severe and persistent mental illnesses such as schizophrenia.15,41 Owen Surman46 is a proponent of improving access to transplantation and has proposed that kidney transplantation is a better alternative than chronic dialysis for psychiatrically ill patients. Most literature on transplanting individuals with serious psychiatric illness is based on anecdotal reports.15,41
Substance abuse is important because of its strong correlation with non-compliance and graft loss.22 Currently in the United States one third of end-stage liver disease patients candidates for liver transplantation have alcohol abuse as an etiology.29 The Beresford Algorithm5 emphasizes the importance of a careful diagnosis, recognition of alcoholism as a disease by the patient and their family, assessment of social stability factors, and evaluation for the attainment of commonly accepted predictors of long-term abstinence from alcohol. For alcohol abusers receiving liver transplantation, positive identification with non-drinking persons, good social support system, effective time structuring, and a smooth medical course are correlated with abstinence.32
Social support is another factor associated with the transplantation outcome. In Brazil this assessment should involve not only family availability, but also organizations for self-support, and churches. A primary care provider should be assigned. His/her roles, including driving the patient to the hospital and doctors' appointments, assisting with medications and supervising the patient's overall well being, need to be explicitly discussed. The program of "health agents" ¾ agentes de saúde ¾ and family doctors, available in some areas of the country, should also be contacted to gather information regarding compliance with medical care and to have cooperation for assistance in the post operative period.
Motivation to undergo transplantation is an issue that the psychiatrist should assess to understand the candidate's reasons for pursuing this treatment. Unrealistic expectations and ambivalence may be a sign for potential problems in the post transplant period. It should always be determined if the individual is undergoing transplantation evaluation due to their own benefit, or if family members, employers, or other third parties with their own interests are coercing them.
The potential transplant candidate's coping strategies are generally reviewed. For some individuals who have developed significant physical limitations as a result of their end-stage illness, developing whole new patterns of behavior may cause significant stress and frustration. Self-destructive responses to stress such as alcohol consumption or denial should be addressed. Patterns of coping with stress and dealing with medical issues will generally continue unless interventions to change them are made.
In an attempt to encourage standardization and research, two rating scales have been developed that incorporate the variables described above in assessing psychosocial factors in transplant patients: the Psychosocial Assessment for Candidates for Transplant (PACT)33 and the Transplantation Evaluation Rating Scale (TERS).50 Each has been shown to be inter-rater reliable and have a good predictive value in determining individuals at risk for poor outcome and noncompliance.36
The primary psychosocial reasons to reject a transplantation candidate are based on their inability to comply with medications and the rehabilitation treatment because of the increased risk of graft loss.23 The significant risks and the exceedingly high costs of transplantation are such that psychosocial factors which negatively affect outcome need to be recognized. Where these exist and will likely prevent graft survival, programs should refuse listing these patients until the issues are addressed. Utilization of a behavioral treatment contract may allow the team sufficient time to discern if the patient may ultimately be able to cooperate and be successfully transplanted. Table 4 provides a list of absolute and relative contraindications for transplantation developed by Strouse & Skotzko.44
There is no consensus is the medical community about absolute and relative psychosocial contraindications to transplantation, with the exception of active or recent substance abuse. Most transplant psychiatrists insist that psychosocial factors should not be taken a priori as immutable, or as definitively precluding candidacy.45,46 Instead, factors once rigidly considered as absolute contraindications to transplant are best viewed as risk factors and as targets of aggressive intervention.
Recent changes in regulations determining the availability of donors in Brazil is expected to increase the potential number of transplantation recipients. There is consistent evidence documenting the role and importance of pre-operative psychosocial evaluations of transplant candidates. A comprehensive evaluation of individuals can clearly elucidate the individual's strengths and weaknesses and allows the necessary treatment to enhance compliance. It is imperative that psychosocial aspects be included in the overall evaluation of an individual's appropriateness for transplantation to provide the transplant team with a global view of the potential problems, which may be predicted in the pre and post-transplant periods.
Consultation liaison psychiatrists are exceptionally well suited to lead the clinical psychosocial assessment of transplantation candidates. In addition to diagnosis, assessment, and case formulation, the organ transplant psychiatrist should be skilled at formulating and implementing specific treatment programs. The usefulness and cost-effectiveness of liaison psychiatrist is also well established.28 By bringing closer consultation liaison psychiatrists to transplant programs, the potential benefits for patients and providers are enormous.
1. Adams DH, Ponsford S, Gunson B, Boon A, Honigsberger L, Williams A et al. Neurological complications following liver transplantation. Lancet 1987;1:949-51. [ Links ]
2. Appelbaum PS, Grisso T. Capacities of hospitalized medically ill patients to consent to treatment. Psychosomatics 1997;38:119-25. [ Links ]
3. Belli LS, De Carlis L, Romani F, Rondinara GF, Rimoldi P, Alberti A et al. Dysarthria and cerebellar ataxia: late occurrence of severe neurotoxicity in a liver transplant recipient. Transpl Int 1993;6:176-8. [ Links ]
4. Berden JHM, Hoitsma AJ, Merx JL, Keyser A. Severe central nervous system toxicity associated with cyclosporine. Lancet 1985;1:219-20. [ Links ]
5. Beresford TP, Turcotte JP, Merion R, Burtch G, Blow FC, Campbell D et al. A rational approach to liver transplantation for alcoholic candidates. Psychosomatics 1990;31:241-54. [ Links ]
6. Bhatt BD, Meriano FV, Buchwald D. Cyclosporine associated central nervous system toxicity [letter]. N Engl J Med 1988;318:788. [ Links ]
7. Botega NJ, Dalgalarrondo P. Saúde mental no Hospital Geral. 2a ed. São Paulo: Hucitec; 1997. [ Links ]
8. Chacko RC, Harper RG, Gotto J, Young J. Psychiatric interview and psychometric predictors of cardiac transplantiation. Am J Psychiatry 1996;153:1607-12. [ Links ]
9. Craven J. Psychiatric aspects of lung transplant: the Toronto Lung Transplant Group. Can J Psychiatry 1990;35:759-64. [ Links ]
10. Craven JL. Cyclosporine-associated organic mental disorders in liver transplant recipients. Psychosomatics 1991;32:94-102. [ Links ]
11. De Bruijn KM, Klompmaker IJ, Slooff MJH, Fockens P, Hillen PH. Cyclosporine neurotoxicity late after liver transplantation.Transplantation 1989;47:575-6. [ Links ]
12. DeGroen P, Aksamit AJ, Rakela J, Forbes GS, Krom RA. Central nervous system toxicity after liver transplantation: the role of cyclosporine and cholesterol. N Engl J Med 1987;317:861-6. [ Links ]
13. DeGroen P, Craven J. Organic brain syndromes in transplant patients. In: Craven J, Rodin G, editors. Psychiatric aspects of organ transplantation. Oxford, UK: Oxford University Press; 1992. p. 67-88. [ Links ]
14. Dew MA, Kormos RL, Roth LH, Murali S, DiMartini A, Griffith BP. Early post transplant medical compliance and mental health predict physical morbidity and mortality one tho three years after heart transplantation. J Heart Lung Transplant 1999;18:549-62. [ Links ]
15. Dimartini A, Twillman R. Organ transplantation and paranoid schizophrenia. Psychosomatics 1994;35:159-60. [ Links ]
16. European FK 506 Multicentre Liver Study Group. Randomised trial comparing tacrolimus to cyclosporine in prevention of liver allograft rejetion. Lancet 1994;344:423-8. [ Links ]
17. Frank B, Perdrizet GA, White HM, Marsh JW, Lemann W, Woodle ES. Neurotoxicity of FK-506 in liver transplant recipients. Transplant Proc 1993;25:1887-8. [ Links ]
18. Frasure-Smith N, Lesperance F, Talajic M. Depression following myocardial infarction. Impact on 6-month survival. JAMA 1993;270:1819-25. [ Links ]
19. Freeman A. Assessment of transplant candidates and prediction of outcome. In: Craven J, Rodin G, editors. Psychiatric aspects of organ transplantation. Oxford, UK: Oxford University Press; 1992. p. 9-19. [ Links ]
20. Freeman AM 3rd, Wesphal JR, Davis LL, Libb JW. The future of organ transplant psychiatry. Psychosomatics 1995;36:429-37. [ Links ]
21. Fryer JP, Fortier MV, Metrakos P, Verran DJ, Asfar SK, Pelz DM et al. Central pontine myelinolysis and cyclosproine neurotoxicity following liver transplantation. Transplantation 1996;61:658-61. [ Links ]
22. Gastfriend DR, Surman OS, Gaffey G. Substance abuse and compliance in organ transplantation. Subst Abuse 1989;10:149-53. [ Links ]
23. House RM. Transplantation surgery. In: Sandemine A, Fogel BS. Psychiatric care of the medical. New York: Oxford University Press; 1993. p. 803-16. [ Links ]
24. Kabeer MH, Filo RS, Milgrom ML, Pescovitz MD, Leapman SB, Lumeng L et al. Central pontine myelinolysis following liver transplant: association with cyclosporine toxicity. Postgrad Med J 1995;71:239-41. [ Links ]
25. Laubenberger J, Schneider B, Ansorge O, Gotz F, Haussinger D, Volk B et al. Central pontine myelinolysis: clinical presentation and radiologic findings. Eur Radiol 1996;6:177-83. [ Links ]
26. Lee YJ, Lee SG, Kwon TW, Park KM, Kim SC, Min PC. Neurologic complications after orthotopic liver transplantation inclind central pontine myelinolysis. Transplant Proc 1996;28:1674-5. [ Links ]
27. Levenson JL, Olbrisch ME. Psychosocial evaluation of organ transplant candidates: a comparative survey of process, criteria, and outcomes in heart, liver, and kidney transplantation. Psychosomatics 1993;34:314-23. [ Links ]
28. Levy NB. Organ transplantation: an ideal that is not feasible [editorial]. Gen Hosp Psychiatry 1998;20:78-9. [ Links ]
29. Loewy EH. Drunks, livers, and values: should social value judgments enter into liver transplant decisions? J Clin Gastroenterol 1987;9:436-41. [ Links ]
30. Lopez OL, Martinez AJ, Torre-Cisneros J. Neuropathologic cyclosporine and FK-506. Transplant Proc 1991;23:3181-2. [ Links ]
31. Lowry MR. Frequency of depressive disorder in patients entering home hemodialysis. J Nerv Ment Dis 1979;167:199-204. [ Links ]
32. Lucey M, Merion R, Henley KS, Campbell DA Jr, Turcotte JG, Nostrant TT et al. Selection for and outcome of liver transplantation in alcoholic liver disease. Gastroenterology 1992;102:1736-41. [ Links ]
33. Olbrisch ME, Levenson J, Hamer R. The PACT: a rating scale for the study of clinical decision-making in psychosocial screening criteria for organ transplant candidates. Clin Transpl 1989;3:164-9. [ Links ]
34. Olbrisch ME, Levenson JL. Psychosocial evaluation of heart transplant candidates: an international survey of process, criteria, and outcomes. J Heart Lung Transplant 1991;10:948-55. [ Links ]
35. Palmer BF, Toto RD. Severe neurologic toxicity induced by cyclosporine A in three renal transplant patients. Am J Kidney Dis 1991;1:116-21. [ Links ]
36. Presberg BA, Levenson JL, Olbrisch ME, Best AM. Rating scales for psychosocial evaluation of organ transplant candidates: comparison of the PACT and TERS with bone marrow transplant patients. Psychosomatics 1995;36:458-61. [ Links ]
37. Rundell JR, Hall RCW. Psychiatric characteristics of consecutively evaluated outpatient renal transplant candidates and comparisons with consultation-liaison inpatients. Psychosomatics 1997;38:269-76. [ Links ]
38. Schleifer SJ, Macari-Hinson MM, Coyle DA, Slater WR, Kahn M, Gorlin R, et al. The nature and course of depression following myocardial infarction. Arch Intern Med 1989;149:1785-9. [ Links ]
39. Shapiro PA, Kornfeld DS. Psychiatric outcome of heart transplantation. Gen Hosp Psychiatry 1989;11:352-7. [ Links ]
40. Shapiro PA,Williams DL, Foray AT, Gelman IS, Wukich N, Sciacca R. Psychosocial evaluation and prediction of compliance problems and morbidity after heart transplantation. Transplantation 1995;60:1462-6. [ Links ]
41. Sills LM, Popkin MK. Elective removal of a transplanted organ. Psychosomatics 1992;33:461-5. [ Links ]
42. Smith MD, Hong BA, Robson AM. Diagnosis of depression in patients with end-stage renal disease: comparative analysis. Am J Med 1985;79:160-6. [ Links ]
43. Strouse TB, Fairbanks LA, Skotzko CE, Fawzi FI. Fluoxetine and cyclosporine in organ transplantation: failure to detect significant drug interactions or adverse clinical events in depressed organ recipients. Psychsomatics 1996;37:23-30. [ Links ]
44. Strouse TB, Wolcott DL, Skotzko CE. Transplantation. In: Rundell JR, Wise MG, editors. Textbook of consultation-liassion psychiatry. Washington (DC): American Psychiatric Press; 1996. [ Links ]
45. Surman OS. Liver transplantation. In: Craven J, Rodin G, editors. Psychiatric aspects of organ transplantation. Oxford, UK: Oxford University Press; 1992. p. 177-88. [ Links ]
46. Surman OS. Psychiatric aspects of organ transplantation [published erratum appears in Am J Psychiatry 1989;146:1523]. Am J Psychiatry 1989;146:972-82. [ Links ]
47. Thompson CB, June CH, Sullivan KM, Thomas ED. Association between cyclosporin neurotoxicity and hypomagnesemia. Lancet 1984;2:1116-20. [ Links ]
48. Tollemar J, Ringden O, Ericzon BG. Cyclosporin associated central nervous system toxicity. N Engl J Med 1988;318:788-9. [ Links ]
49. Trzepacz PT, Brenner R, Van Thiel DH. A psychiatric study of 247 liver transplantation candidates. Psychosomatics 1989;30:147-53. [ Links ]
50. Twillman RK, Manetto C, Wolcott DL. The transplant evaluation scale: a revision of the psychosocial levels system for evaluating organ transplant candidates. Psychosomatics 1993;34:144-53. [ Links ]
51. US Multicenter FK506 Liver Study Group. A comparison of tacrolimus and cyclosporine for immunosuppresion in liver transplantation. N Engl J Med 1994;331:1110-5. [ Links ]
52. Vogt DP, Lederman RJ, Carey WD, Broughan TA. Neurologic complication after liver transplantation. Transplantation 1988;45:1057-61. [ Links ]
53. Wilczek H, Rigden O, Tyden G. Cyclosporine associated central nervous system toxicity after renal transplantation [letter]. Transplantation 1984;39:110. [ Links ]
54. Winnock S, Janvier G, Parmentier F, Duche B, Daverat P, Combe C et al. Pontine myelinolysis following liver transplantation: a report of two cases. Transpl Int 1993;6:26-8. [ Links ]
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Submitted on 4/11/1999. Approved on 25/2/2000.