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Revista do Instituto de Medicina Tropical de São Paulo

On-line version ISSN 1678-9946

Rev. Inst. Med. trop. S. Paulo vol.28 no.2 São Paulo Mar./Apr. 1986

http://dx.doi.org/10.1590/S0036-46651986000200001 

ARTIGOS ORIGINAIS

 

Atividade dissacaridásica intestinal da esquistossomose mansônica. Estudo evolutivo em camundongos com diferentes cargas de infestação

 

Intestinal disaccharidase activity in schistosomiais mansoni. An evolutionary study of mice with different degrees of infestation

 

 

M. G. A. SadekI; D. R. BorgesII; S. J. MiszputenII

IProfessora Assistente da Disciplina de Nutrição da Escola Paulista de Medicina São Paulo, Brasil
IIProfessor Adjunto da Disciplina de Gastroenterologia Clínica da Escola Paulista de Medicina

 

 


RESUMO

A esquistossomose mansônica compromete vários órgãos, sendo o intestino e o fígado os mais agredidos. Com a intenção de verificar o comprometimento do intestino delgado, dependente da intensidade e do tempo de infecção pelo Schistosoma mansoni, analisou-se a atividade das dissacaridases — lactase, sacarase e maltase — em 112 camundongos, distribuídos em 3 grupos: grupo I — controle, grupo II — infestado com 30 cercárias, grupo III — infestado com 60 cercárias. Observamos uma diminuição da atividade lactásica, sacarásica e maltásica do intestino delgado, decorrente da infestação esquistossomdtica, do tempo de infestação e da alteração entre ambos. O íleo é o segmento que demonstrou maior sensibilidade a esquistossomose, tendo uma diminuição das suas dissacaridases a partir da fase inicial de infestação. Opostamente, o jejuno só mais tardiamente mostra essas alterações, exceto em relação a lactase. Detectou-se um aumento da atividade dissacaridásica, inclusive para a lactase, em todos os grupos, com a evolução etária dos animais, quantitativamente menor nos infestados. Cargas de 30 e 60 cercárias devem ser consideradas de mesmo porte, pois produziram ledução semelhante na atividade dissacaridásica.

Unitermos: Esquistossomose mansônica — Dissacaridases.


SUMMARY

Schistosomiasis mansoni attacks a number of organs, of which the intestine and liver are the most affected. This analysis was undertaken in order to verify the degree to which the small intestine is attacked, in accordance with the intensity and duration of infestation by Schistosoma mansoni; it focused on the activity of disaccharidase — lactase, saccharase and maltase — in 112 mice, divided into 3 groups: group I, for control; group II, infested with 30 cercariae; and group III, infested with 60 cercariae.
We observed a fall in lactase, saccharase and maltase activity in the small intestine, as a result of infestation by schistosomiasis, of the duration of infestation and of the interaction between the two. The ileum was the section showing greatest sensitivity to schistosomiasis, and its disaccharidases fell off right from the start of infestation. On the other hand, the jejunum only showed such alterations much later on, except as regards lactase. An increase in disaccharidase activity was detected in all groups as the age of the animals increased, but this was quantitatively lower in the infested animals.
Infestation with 30 and 60 cercariae should he seen as of the same degree, as they produced similar reductions in disaccharidase activity.


 

 

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Recebido para publicação em 3/1/1985.

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