Tratamiento com levamisol de la infeccion por Mansonella ozzardi

Restrepo, Marcos; Ochoa, Nubla

doi:10.1590/S0036-46651986000200007

Resúmenes

La administración de levamisol a la dosis para adultos, de 150 mg durante 2 a 3 meses, estuvo asociada la disminución y finalmente a la desaparición de microfilarias circulantes de Mansonella ozzardi. No se presentaron reacciones secundarias a la droga y la eosinofilia circulante, sirvió como indicador de la presencia de microfilarias.

Mansonella ozzardi; Tratamiento con levamisol

Administration of levamisole at the adult dosage (150mg/day) for period of 2-3 months, was found to be associated with diminishing numbers and late disappearence of circulating Mansonella ozzardi microfilarias. No adverse reactions to the drug were recorded. The degree of circulating eosinophils served as indicator of the microfilaria presence.

THERAPEUTIC ASSAYS

Tratamiento com levamisol de la infeccion por Mansonella ozzardi

Mansonella ozzardi infection treated by levamisole

Marcos Restrepo^I; Nubla Ochoa^II

^ILaboratorio Departamental de Salud Publica (SSSA). y Corporación para Investigaciones Biológicas (CIB) Medellín Colombia

^IILaboratorio Departamental de Salud Pública (SSSA) Medellín, Colombia sionero en diferentes sitios del Vaupés, Colombia

RESUMEN

La administración de levamisol a la dosis para adultos, de 150 mg durante 2 a 3 meses, estuvo asociada la disminución y finalmente a la desaparición de microfilarias circulantes de Mansonella ozzardi. No se presentaron reacciones secundarias a la droga y la eosinofilia circulante, sirvió como indicador de la presencia de microfilarias.

Unitermos:Mansonella ozzardi Tratamiento con levamisol

SUMMARY

Administration of levamisole at the adult dosage (150mg/day) for period of 2-3 months, was found to be associated with diminishing numbers and late disappearence of circulating Mansonella ozzardi microfilarias. No adverse reactions to the drug were recorded. The degree of circulating eosinophils served as indicator of the microfilaria presence.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

AGRADECIMIENTOS

Al Dr. D. Botero, Facultad de Medicina, Universidad de Antioquia por el envío de uso de los pacientes.

Recebido para publicação em 28/5/1985.

1. ESSLINGER, J. H. & JIMENEZ, A. - Human In fection with the Filaria Mansonella ozzardi in Colombia. Bull. Tulane med. Fac., 27: 81-91, 1968.
2. EESTREPO, M. Estudio parasitológico de una región del Amazonas colombiano. Antioquia med., 12: 462-484, 1962.
3. KOZEK, W. J.; D'ALESSANDRO, A.; SILVA, J. & NAVARRETTE, S. N. Filariasis in Colombia: pre- valence of Mansonella in the teenage and adult population of the Colombian bank of the Amazon, Comisaria del Amazonas, Amer. J. trop. Med. Hyg., 31: 1131-1136, 1982.
4. RESTREPO, M. ; BRAVO, C; MEJIA, W.; BOTERO, V. M. & ABAD, H. Estudio clínico y epidemiológico de una población de los Llanos Orientales, Colombia. Antioquia méd., 15: 283-284, 1965.
5. MARINKELLE, C & GERMAN, E. Mansonellosis in the Comisaria del Vaupés of Colombia. Trop. Geogr. Med., 22: 101-111, 1970.
6. KOZEK, W. J.; PALMA, G. ; HENAO, A.; GARCIA, H-& HOYOS, M. Pilariasis in Colombia: Prevalence and distribution of Mansonella ozzardi and Mansonella (Dipetalonema) perstans infections in the Comisaria del Guainía. Amer. J. trop. Med. Hyg., 32: 379-384, 1983.
7. KOZEK, W. J.; PALMA, G, ; VALENCIA, W.; MONTALVO, C. & SPAIN, J. Filariasis in Colombia: Prevalence of Mansonella ozzardi in the departamento del Meta, Intendencia del Casanare and Comisaria del Vichada. Amer. J. trop. Hyg., 33: 70-72, 1984.
8. RESTREPO, M. ; LATORRE, R. & BOTERO, D. Presentación de un caso de mansonelosis. Antioquia méd., 12: 233-242, 1962.
9. MANSON-BAHR, P. E. C. & WIJERS, D. J. B. The effect of a small dose of diethylcarbamazine on the circulation in the blood of microfilariae of W. bancrofti. Trans. roy. Soc. trop. Med. Hyg., 66: 18, 1972.
10. RUSSEL, S-; SUNDARAM, R. M.; CHANDRASEKHARAN, A. & RAO, C. K. Provocative effect of daytime administration of diethycarbamazine on microfilaraemia of Wuchereria bancrofti and Brugia malayt. J. Communlcat. Disor., 7: 59-64, 1975.
11. PARTONO, F.; PURNOMO; OEMIJATI, S. & SOEWARTA, A. The long term effects of repeated diethylcarbamazine administration with special reference to microfilaremia and elephantiasis. Acta trop. (Basel), 38: 217-225, 1981.
12. MAZZOTI, L. Resultados negativos de la administracidn del "Hetrazén" en dos pacientes infectados con Mansonella ozzardi Medicina (Méx.), 28: 317-318, 1948.
13. MONTESTRUC, E.; BLANCHE, R. & LABORDE, R. Action du 1-diéthylcarbamyl 4-methylpiperazine sur Filaria ozzardi. Bull. Soc. Path. exot., 43: 275-278, 1950.
14. BARTHOLOMEW, C. F.; NATHAN, M. B. & TIKASINGH, E. S. The failure of diethylcarbamazine in the treatment of Mansonella ozzardi infections. Trans, roy. Soc. trop. Med. Hyg., 72: 423-424, 1978.
15. THIENPONT, D.; BRUGMANS, J.; ABADI, K. & TANAMAL, S. Evaluation of tetramisol in the treatment of nematode infection In man. Amer. J. trop. Med. Hyg., 18: 520-525, 1969.
16. SYMOENS, J. et al. Levamisole. Pharmacological and Biochemical Properties of Drag Sustances Am. Pharmaceut. Ass., 1979. Vol. 2.
17. SYMENS, J.; VEYS, E.; MIELANTS, M. & PINALS, .R Adverse reactions to levamisole. Cancer Treat. Rep. 62: 1721-1730, 1978.
18. GOLDSTEIN, L. Mode of action of Levamisole. J. Rheum., 5 (Suppl. 4): 143-148, 1978.
19. PEREZ, J.; LASTRE, M.; LAZO, O. & MONTALVO, G. Uso del Levamisol en la filariasis por W. bancrofti. Rev. cuba. Med. trop., 32: 185-190, 1980.
20. MAK, J. W. & ZAMAN, V. Levamisole hydrochloride in Brugia malayi and Buchereria bancrofti infection. Hlth. Policies Develop. Countries: Roy.. Soc. Med. Int. Congress Symposium Series No. 24. London, Academic Press, 1979.
21. LOUIS, F. J. & LAIGRET, J. Essai de l'association diethylcarbamazine (Notézine) Levamisole (Solaskil) dans la lutte contre la filariose a Wuchereria bancrofti, var. pacifica, en Polynésie Française. Bull. Soc. Path, exot., 72: 471-481, 1979.
22. TEMU, S. E. & MCMAHON, J. E. Chemotherapy with spaced doses of diethylcarbamazine preceded by levamisole in Bancroftian Filariasis. Trans. roy. Soc. trop. Med. Hyg., 75: 835-837, 1981.
23. MAERTENS, K. & WERY, M. Effect of mebendazole and levamisole on Onchocerca volvulus and Dipetalonema perstans. Trans. roy. Soc. trop. Med. Hyg., 69: 359-360, 1975.
24. BERNBERG, H. C; CLARKE, V. de V. & GELFAND, M. The combined treatment with levamisole and mebendazole for a perstans-like filarial infection in Rhodesia. Trans. roy. Soc. trop. Med. Hyg., 73: 233-234, 1979.
25. BOSSCHE, H. D. Antifllarial activity of Levamisole Mebendazole-Flubendazole. Hlth. Policies Develop. Countries: Roy. Soc. Med. Int. Congress-Symposium Series No. 24. London, Academic Press, 1980.
26. WAHLGREN, M. The successful treatment Of Dipetalonema perstans with mebendazole. Ann. trop. Med. Parasit., 76: 557-579, 1982.
27. WAHLGREN, M. & FROLOV, I. Treatment of Dipetalonema perstans infections with mebendazole. Trans. roy. Soc. trop. Med. Hyg., 77: 422-423, 1983.

Fechas de Publicación

Publicación en esta colección
16 Oct 2012
Fecha del número
Abr 1986

Histórico

Recibido
28 Mayo 1985

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ESSLINGER, J. H. & JIMENEZ, A. - Human In fection with the Filaria Mansonella ozzardi in Colombia. Bull. Tulane med. Fac., 27: 81-91, 1968.

[2] 2. EESTREPO, M. Estudio parasitológico de una región del Amazonas colombiano. Antioquia med., 12: 462-484, 1962.

[3] 3. KOZEK, W. J.; D'ALESSANDRO, A.; SILVA, J. & NAVARRETTE, S. N. Filariasis in Colombia: pre- valence of Mansonella in the teenage and adult population of the Colombian bank of the Amazon, Comisaria del Amazonas, Amer. J. trop. Med. Hyg., 31: 1131-1136, 1982.

[4] 4. RESTREPO, M. ; BRAVO, C; MEJIA, W.; BOTERO, V. M. & ABAD, H. Estudio clínico y epidemiológico de una población de los Llanos Orientales, Colombia. Antioquia méd., 15: 283-284, 1965.

[5] 5. MARINKELLE, C & GERMAN, E. Mansonellosis in the Comisaria del Vaupés of Colombia. Trop. Geogr. Med., 22: 101-111, 1970.

[6] 6. KOZEK, W. J.; PALMA, G. ; HENAO, A.; GARCIA, H-& HOYOS, M. Pilariasis in Colombia: Prevalence and distribution of Mansonella ozzardi and Mansonella (Dipetalonema) perstans infections in the Comisaria del Guainía. Amer. J. trop. Med. Hyg., 32: 379-384, 1983.

[7] 7. KOZEK, W. J.; PALMA, G, ; VALENCIA, W.; MONTALVO, C. & SPAIN, J. Filariasis in Colombia: Prevalence of Mansonella ozzardi in the departamento del Meta, Intendencia del Casanare and Comisaria del Vichada. Amer. J. trop. Hyg., 33: 70-72, 1984.

[8] 8. RESTREPO, M. ; LATORRE, R. & BOTERO, D. Presentación de un caso de mansonelosis. Antioquia méd., 12: 233-242, 1962.

[9] 9. MANSON-BAHR, P. E. C. & WIJERS, D. J. B. The effect of a small dose of diethylcarbamazine on the circulation in the blood of microfilariae of W. bancrofti. Trans. roy. Soc. trop. Med. Hyg., 66: 18, 1972.

[10] 10. RUSSEL, S-; SUNDARAM, R. M.; CHANDRASEKHARAN, A. & RAO, C. K. Provocative effect of daytime administration of diethycarbamazine on microfilaraemia of Wuchereria bancrofti and Brugia malayt. J. Communlcat. Disor., 7: 59-64, 1975.

[11] 11. PARTONO, F.; PURNOMO; OEMIJATI, S. & SOEWARTA, A. The long term effects of repeated diethylcarbamazine administration with special reference to microfilaremia and elephantiasis. Acta trop. (Basel), 38: 217-225, 1981.

[12] 12. MAZZOTI, L. Resultados negativos de la administracidn del "Hetrazén" en dos pacientes infectados con Mansonella ozzardi Medicina (Méx.), 28: 317-318, 1948.

[13] 13. MONTESTRUC, E.; BLANCHE, R. & LABORDE, R. Action du 1-diéthylcarbamyl 4-methylpiperazine sur Filaria ozzardi. Bull. Soc. Path. exot., 43: 275-278, 1950.

[14] 14. BARTHOLOMEW, C. F.; NATHAN, M. B. & TIKASINGH, E. S. The failure of diethylcarbamazine in the treatment of Mansonella ozzardi infections. Trans, roy. Soc. trop. Med. Hyg., 72: 423-424, 1978.

[15] 15. THIENPONT, D.; BRUGMANS, J.; ABADI, K. & TANAMAL, S. Evaluation of tetramisol in the treatment of nematode infection In man. Amer. J. trop. Med. Hyg., 18: 520-525, 1969.

[16] 16. SYMOENS, J. et al. Levamisole. Pharmacological and Biochemical Properties of Drag Sustances Am. Pharmaceut. Ass., 1979. Vol. 2.

[17] 17. SYMENS, J.; VEYS, E.; MIELANTS, M. & PINALS, .R Adverse reactions to levamisole. Cancer Treat. Rep. 62: 1721-1730, 1978.

[18] 18. GOLDSTEIN, L. Mode of action of Levamisole. J. Rheum., 5 (Suppl. 4): 143-148, 1978.

[19] 19. PEREZ, J.; LASTRE, M.; LAZO, O. & MONTALVO, G. Uso del Levamisol en la filariasis por W. bancrofti. Rev. cuba. Med. trop., 32: 185-190, 1980.

[20] 20. MAK, J. W. & ZAMAN, V. Levamisole hydrochloride in Brugia malayi and Buchereria bancrofti infection. Hlth. Policies Develop. Countries: Roy.. Soc. Med. Int. Congress Symposium Series No. 24. London, Academic Press, 1979.

[21] 21. LOUIS, F. J. & LAIGRET, J. Essai de l'association diethylcarbamazine (Notézine) Levamisole (Solaskil) dans la lutte contre la filariose a Wuchereria bancrofti, var. pacifica, en Polynésie Française. Bull. Soc. Path, exot., 72: 471-481, 1979.

[22] 22. TEMU, S. E. & MCMAHON, J. E. Chemotherapy with spaced doses of diethylcarbamazine preceded by levamisole in Bancroftian Filariasis. Trans. roy. Soc. trop. Med. Hyg., 75: 835-837, 1981.

[23] 23. MAERTENS, K. & WERY, M. Effect of mebendazole and levamisole on Onchocerca volvulus and Dipetalonema perstans. Trans. roy. Soc. trop. Med. Hyg., 69: 359-360, 1975.

[24] 24. BERNBERG, H. C; CLARKE, V. de V. & GELFAND, M. The combined treatment with levamisole and mebendazole for a perstans-like filarial infection in Rhodesia. Trans. roy. Soc. trop. Med. Hyg., 73: 233-234, 1979.

[25] 25. BOSSCHE, H. D. Antifllarial activity of Levamisole Mebendazole-Flubendazole. Hlth. Policies Develop. Countries: Roy. Soc. Med. Int. Congress-Symposium Series No. 24. London, Academic Press, 1980.

[26] 26. WAHLGREN, M. The successful treatment Of Dipetalonema perstans with mebendazole. Ann. trop. Med. Parasit., 76: 557-579, 1982.

[27] 27. WAHLGREN, M. & FROLOV, I. Treatment of Dipetalonema perstans infections with mebendazole. Trans. roy. Soc. trop. Med. Hyg., 77: 422-423, 1983.

Brasil

Brasil

Tratamiento com levamisol de la infeccion por Mansonella ozzardi

Mansonella ozzardi infection treated by levamisole

Resúmenes

Fechas de Publicación

Histórico