Immunoserology of malaria

Franco, Eduardo L. F.

doi:10.1590/S0036-46651986000200008

Abstracts

This literature review discusses the most frequently used serodiagnostic methods for the determination of the humoral immune response to malarial parasites. The importance of malaria as a global public health problem is stressed in the light of the new discoveries leading to the future development of an anti-malarial vaccine suitable for use in humans. Serological techniques are expected to play an important role in the assessment of the relative efficacy of these candidate vaccines. A discussion of the different antigen preparation techniques is also presented.

Malaria; Serodiagnostic methods; Humoral immune response; Antigen preparation techniques

Neste trabalho são revistos os métodos sorodiagnósticos mais frequentemente utilizados para a determinação da resposta imune humoral aos parasitas da malária. A importância desta doença como um problema mundial de saúde pública é enfatizada à luz das novas descobertas no campo imunológico que poderão culminar no desenvolvimento de uma vacina adequada para uso humano. A aplicação de técnicas sorológicas certamente será de extrema importância na avaliação da eficácia relativa destas potenciais vacinas. Discute-se também, no presente trabalho, as diferentes técnicas de preparação de antígenos.

REVIEW

Immunoserology of malaria

Imuno-sorologia da malária

Eduardo L. F. Franco

Malaria Branch. Division of Parasitic Diseases Centers of Disease Control. Atlanta, Georgia, USA

^{Present address} Present address: Ludwig Institute for Cancer Research R. Prof. Antonio Prudente, 109 4.° andar 01509 São Paulo SP BRASIL

SUMMARY

This literature review discusses the most frequently used serodiagnostic methods for the determination of the humoral immune response to malarial parasites. The importance of malaria as a global public health problem is stressed in the light of the new discoveries leading to the future development of an anti-malarial vaccine suitable for use in humans. Serological techniques are expected to play an important role in the assessment of the relative efficacy of these candidate vaccines. A discussion of the different antigen preparation techniques is also presented.

Key words: Malaria Serodiagnostic methods Humoral immune response Antigen preparation techniques.

RESUMO

Neste trabalho são revistos os métodos sorodiagnósticos mais frequentemente utilizados para a determinação da resposta imune humoral aos parasitas da malária. A importância desta doença como um problema mundial de saúde pública é enfatizada à luz das novas descobertas no campo imunológico que poderão culminar no desenvolvimento de uma vacina adequada para uso humano. A aplicação de técnicas sorológicas certamente será de extrema importância na avaliação da eficácia relativa destas potenciais vacinas. Discute-se também, no presente trabalho, as diferentes técnicas de preparação de antígenos.

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Recebido para publicação em 18/3/1985.

Use of trade names is for identification only and does not imply endorsement by the Public Health Service or the U.S. Department of Health and Human Services.

1. ALLISON, A. C. & EUGUI, E. M. A radical interpretation of immunity to malaria parasites. Lancet. 3: 3431-1433, 1982.
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3. ANONYMOUS Malaria control a reoriented strategy. Chron. Wld. HIth. Org., 32: 226-230, 1978.
4. ANONYMOUS Development of malaria vaccines UNDP/World Bank/WHO/TDR Document, TDR/IMMAL/ SWG, (5) 82 3., 1982.
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Present address:

Ludwig Institute for Cancer Research

R. Prof. Antonio Prudente, 109 4.° andar

01509 São Paulo SP BRASIL

Publication Dates

Publication in this collection
16 Oct 2012
Date of issue
Apr 1986

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ALLISON, A. C. & EUGUI, E. M. A radical interpretation of immunity to malaria parasites. Lancet. 3: 3431-1433, 1982.

[2] 2. AMBROISE-THOMAS, P.; BERTAGNA, P.; COLLINS, W. E.; GODAL, I.; GRAMICCTA, G.; HAWORTH, J.: KENT, N.; McGREGOR, J. A.; MEUWISSEN, J. H. E. T.; ROWE, D. S.; VOLLER, A.; WERNSDORFER, W. & WILLIAMS, A. I. O. Serological testing in malaria. Bull. Wld. HIth. Org., 50; 527-535, 1974.

[3] 3. ANONYMOUS Malaria control a reoriented strategy. Chron. Wld. HIth. Org., 32: 226-230, 1978.

[4] 4. ANONYMOUS Development of malaria vaccines UNDP/World Bank/WHO/TDR Document, TDR/IMMAL/ SWG, (5) 82 3., 1982.

[5] 5. BI DWELL, D. E. & VOLLER, A. Malaria diagnosis by enzyme-united immunosorbent assays. Brit. med. J., 282: 1747-1748, 1981.

[6] 6. BILLIAULT, X. & AMBROISE-THOMAS, P. Isolation of Plasmodium falciparum merozoites from cultivated scbizonts bound to concanavalin A. Ann. trop. Med Parasit,, 74: 249-250, 1980.

[7] 7. BROOKE, M. M.; HEALY, G, H. & MELVIN, D. M Staining Plasmodium berghei with fluorescein labelled antibodies. Proc. 6th. Int. Congr. trop. Med. Malar., 7: 59, 1959.

[8] 8. BROWN, G. V.; ANDERS, R. F.; MITCHELL, G. F. & HEYWOOD, P. F. Target antigens of purified human immunoglobulins which inhibit growth of Plasmodium falciparum in vitro. Nature (Lond.), 297: 591-593, 1982.

[9] 9. BROWN, I. N.; ALLISON, A. C. & TAYLOR, R. B. Plasmodium berghei infection in thymectomized rats. Nature (Lond.), 219: 292-297, 1968.

[10] 10. CAMPBELL, C. C. & CHIN, W. Diagnosing and monitoring malaria. Diagn. Med., 4: 46-49, 1981.

[11] 11. CAMPBELL, G. H-; MREMA, J. E. K-; O'LEARY. T. R.; JOST, R. C. & RIECKMANN, K. H. In vitro inhibition of the growth of Plasmodium falciparum by Aotus serum. Bull. Wld. Hlth, Org., 57 (suppl.): 219-225, 1979.

[12] 12. CHANDANARI, R. E.; MAHAJAN, R. C; PRASAD, R. N. & GANGULY, N. K. Evaluation of Plasmodium knowlesi antigen for serodiagnosis of human malaria infection. Indian. J. med. Res., 73: 41-44, 1981.

[13] 13. CHIN, W.; MOSS, D. L. & COLLINS, W. E. The continuous cultivation of Plasmodium fragile by the method of Trager-Jensen. Amer. J. trop. Med. Hyg., 28: 591-592, 1979.

[14] 14. CHOWDHURI, A. N. R.; CHOWDHURI, D. S. & REGIS, M. L. Simultaneous propagation of Plasmodium malariae and Plasmodium falciparum in a continuous culture. In: Rowe, D. S. & Hirumi, H., ed. The in vitro cultivation of the pathogens of tropical diseases. Basel, Schwabe, 1980. p. 103.

[15] 15. CHULAY, J. D.; HAYNES, J. D. & DIGGS, C L. Inhibition of in vitro growth of Plasmodium falciparum by immune serum from monkeys. J. infect. Dis-, 144: 270-278, 1981.

[16] 16. COHEN, S. Immunity to malaria. Proc. roy. Soc. Lond. B. 203: 323-345, 1979.

[17] 17. COHEN, S.; BUTCHER, G. A. & CRANDALL, R. B. Action of malarial antibody in vitro. Nature (Lond.), 223: 368-371, 1969.

[18] 18. COHEN, S.; BUTCHER, G. A.; MITCHELL, G. H.; DEANS, J. & LANGHORNE, J. Acquired immunity and vaccination in malaria. Amer. J. trop. Med. Hyg., 26: 223-232, 1977.

[19] 19. COLLINS, W. E. & SKINNER, J. C The indirect fluorescent antibody test in malaria. Amer. J. trop. Med. Hyg., 21: 690-695, 1972.

[20] 20. COLLINS, W. E.; SKINNER, J. C. & COIFMAN, R. E. Fluorescent antibody studies in human malaria. V. Response of sera from Nigerians to five Plasmodium antigens. Amer. J. trop. Med. Hyg., 16: 568-571, 1967.

[21] 21. COLLINS, W. E.; JEFFREY, G. M.; GUI NN, E. G. & SKINNER, J. C Fluorescent antibody studies in human malaria. IV. Cross-reactions between human and simian malaria. Amer. J. trop. Med. Hyg., 15: 11-15, 1966.

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Immunoserology of malaria

Imuno-sorologia da malária

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