Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

Cunha-Melo, José Renan da; Coelho, Paulo Marcos Z.

doi:10.1590/S0036-46651986000400010

Abstracts

Mice experimentally infected with Schistosoma mansoni were injected with sodium thiopental or sodium antimonyl gluconate (Triostib R), or submitted to halothane inhalation, with or without a previous injection of thiopental. Data obtained showed that halothane and thiopental induce worm shift to the liver (99 and 76%, respectively). Sodium gluconate and antimonium (Triostib R) shifted 52% of worms towards the liver. These results seem to indicate that the use of antimonium would be unnecessary, when surgical removal of schistosomules is carried out through the extracorporeal filtration technique, in patients with portal hypertension.

Manson schistosomiasis; Experimental disease in mice; Antimonial drugs; Worm shift

Camundongos experimentalmente infectados com Schistosoma mansoni foram injetados com tiopental sódico ou antimonial (TriostibR), ou submetidos à inalação de halotano, com ou sem uma injeção prévia de tiopental. Os resultados mostraram que o halotano e o tiopental induzem, respectivamente, o deslocamento de 99 e 76% dos vermes para o fígado. Gluconato de sódio e antimonio (Triostib R) deslocou 52% de vermes. Estes resultados parecem indicar que o uso de antimonial seria desnecessário quando se faz a remoção cirúrgica de esquistossomos pela técnica de filtração extracorpórea em pacientes com hipertensão portal.

Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

Schistosoma mansoni: efeitos de anestésicos e antimonial (Triostib ^R) sobre o deslocamento de vermes no camundongo

José Renan da Cunha-Melo^I; Paulo Marcos Z. Coelho^II

^IDepartamento de Cirurgia, Faculdade de Medicina da Universidade Federal de Minas Gerais

^IIDepartamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais. Caixa Postal 2486. CEP 30000 Belo Horizonte MG, Brasil

SUMMARY

Mice experimentally infected with Schistosoma mansoni were injected with sodium thiopental or sodium antimonyl gluconate (Triostib R), or submitted to halothane inhalation, with or without a previous injection of thiopental.

Data obtained showed that halothane and thiopental induce worm shift to the liver (99 and 76%, respectively). Sodium gluconate and antimonium (Triostib R) shifted 52% of worms towards the liver.

These results seem to indicate that the use of antimonium would be unnecessary, when surgical removal of schistosomules is carried out through the extracorporeal filtration technique, in patients with portal hypertension.

Key words: Manson schistosomiasis Experimental disease in mice Antimonial drugs Worm shift

RESUMO

Camundongos experimentalmente infectados com Schistosoma mansoni foram injetados com tiopental sódico ou antimonial (Triostib^R), ou submetidos à inalação de halotano, com ou sem uma injeção prévia de tiopental. Os resultados mostraram que o halotano e o tiopental induzem, respectivamente, o deslocamento de 99 e 76% dos vermes para o fígado. Gluconato de sódio e antimonio (Triostib ^R) deslocou 52% de vermes. Estes resultados parecem indicar que o uso de antimonial seria desnecessário quando se faz a remoção cirúrgica de esquistossomos pela técnica de filtração extracorpórea em pacientes com hipertensão portal.

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ACKNOWLEDGEMENTS

The authors are indebted to Mr. Alberto Geraldo dos Santos, Mrs. Alice Neni Parte Batista, and Miss Zenir de Souza for their technical assistance. They are also grateful to Mrs. Vera de Paula Ribeiro for her suggestions concerning the English text.

Recebido para publicação em 26/9/1985

1. BRITO, T.; BONI, D.; LOFES, J. D. & SILVA, L. C. Kidney biopsy in human Schistosomiasis. An ultrastructural study. (Preliminary report). Rev. Inst. Med. trop. S. Paulo, 11: 62-64, 1969.
2. BRITO, T.; GUNJI, J.; CAMARGO, M. E.; CERAVALO. A. & SILVA, L. C. Glomerular lesions in experimental infections of Schistosoma mansoni in Cebus apella monkey. Bull. Wld. Hlth. Org., 45: 419-422, 1971.
3. CHA, Y. N. Inducibility of the hepatic drug metabolizing capacity of mice infected with Schistosoma mansoni. Amer. J. trop. Med. Hyg., 27: 1181-1187, 1978.
4. CHA, Y. N. & BUEDING, E. Recovery of the hepatic drug metabolizing capacity in mice infected with Schistosoma mansoni following curative chemotherapy with the schistosomicid 4-tsothiocyano-4'-nitro-diphenylamine (CGP 4540). Amer. J. trop. Med. Hyg., 27: 1188-1191, 1978.
5. CHA, Y. N.; BYRAM, J. B.; HEINE, H. S. & BUEDING, E. Effect of Schistosoma mansoni infections on hepatic drug metabolizing capacity of athymic nude mice. Amer. J. trop. Med. Hyg., 29: 234-238, 1980.
6. CHEEVER, A. W.; DE WITT, W. B. & WARREN, K. S. Repeated infection' and treatment of mice with Schistosoma mansoni. Functional, anatomic, and immunologic observations. Amer. J. trop. Med. Hyg., 14: 239-253, 1965.
7. COELHO, P. M. Z.; FREIRE, A. C. T.; ARAUJO, P. G.; PELLEGRINO, J. & PEREIRA, L. H. Effect of Schistosoma mansoni infection on pentobarbital-induced sleeping-time in mice. Amer. J. trop. Med. Hyg., 26: 186-187, 1977.
8. GOLDSMITH, E. I. & KEAN, B. H. Schistosomiasis: experimental surgical removal of adult worms. Gastroenterology, 50: 805-807, 1966.
9. GOLDSMITH, E. I.; LUZ, F. F. C.; PRATA, A. & KEAN, B. H. - Surgical recovery of schistosomes from the portal blood. Treatment of the parasitization in man. J. Amer. med. Ass., 199: 235-240, 1967.
10. GOODMAN, L. S. & GILMAN, A. The pharmacological basis of therapeutics 4th ed. London, MacMillan, 1970.
11. HILLYER, G. V. & LEWERT, R. M. Studies on renal pathology in hamsters infected with Schistosoma mansoni and Schistosoma japonicum. Amer. J. trop. Med. Hyg., 23: 404-411, 1974.
12. NATALI, P. J. & CIOLI, D. Immune complex nephritis in mice infected with Schistosoma mansoni. Fed. Proc., 33: 757, 1974.
13. PELLEGRINO, J. & SIQUEIRA, A. F. Técnica do perfusão para colheita de Schistosoma mansoni em cobaias experimentalmente infestadas. Rev. bras. Malar., 8: 589-597, 1956.
14. QUEIROZ, F. P.; BRITO, E.; MARTINELLI, R. & KOCHA, H. Nephrotic syndrome in patients with Schistosoma mansoni infection. Amer. J. trop. Med. Hyg., 22: 622-628, 1973.
15. SILVA, L. C.; BRITO, T.; CAMARGO, M. E.; DE BONI, D. R.; LOPES, J. D. & GUNJI, J. Kidney "biopsy in the hepatosplenic form of infection with Schistosoma mansoni in man. Bull. Wld. Hlth. Org., 42: 907-910, 1970.
16. VALADARES, T. E.; COELHO, P. M. Z. & SAMPAIO. I. B. M. Schistosoma mansoni: aspectos da oviposição (distribuição de ovos nos intestinos e fígado de camundongo e eliminação destes pelas fezes) das cepas LE e CA. Rev. bras. Malar., 32: 53-59, 1981.
17. WARREN, K. S. The immunopathogenesis of schistosomiasis: a multidisciplinary approach. Trans. roy Soc. trop. Med. Hyg., 66: 417-434, 1972.

Publication Dates

Publication in this collection
16 Oct 2012
Date of issue
Aug 1986

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BRITO, T.; BONI, D.; LOFES, J. D. & SILVA, L. C. Kidney biopsy in human Schistosomiasis. An ultrastructural study. (Preliminary report). Rev. Inst. Med. trop. S. Paulo, 11: 62-64, 1969.

[2] 2. BRITO, T.; GUNJI, J.; CAMARGO, M. E.; CERAVALO. A. & SILVA, L. C. Glomerular lesions in experimental infections of Schistosoma mansoni in Cebus apella monkey. Bull. Wld. Hlth. Org., 45: 419-422, 1971.

[3] 3. CHA, Y. N. Inducibility of the hepatic drug metabolizing capacity of mice infected with Schistosoma mansoni. Amer. J. trop. Med. Hyg., 27: 1181-1187, 1978.

[4] 4. CHA, Y. N. & BUEDING, E. Recovery of the hepatic drug metabolizing capacity in mice infected with Schistosoma mansoni following curative chemotherapy with the schistosomicid 4-tsothiocyano-4'-nitro-diphenylamine (CGP 4540). Amer. J. trop. Med. Hyg., 27: 1188-1191, 1978.

[5] 5. CHA, Y. N.; BYRAM, J. B.; HEINE, H. S. & BUEDING, E. Effect of Schistosoma mansoni infections on hepatic drug metabolizing capacity of athymic nude mice. Amer. J. trop. Med. Hyg., 29: 234-238, 1980.

[6] 6. CHEEVER, A. W.; DE WITT, W. B. & WARREN, K. S. Repeated infection' and treatment of mice with Schistosoma mansoni. Functional, anatomic, and immunologic observations. Amer. J. trop. Med. Hyg., 14: 239-253, 1965.

[7] 7. COELHO, P. M. Z.; FREIRE, A. C. T.; ARAUJO, P. G.; PELLEGRINO, J. & PEREIRA, L. H. Effect of Schistosoma mansoni infection on pentobarbital-induced sleeping-time in mice. Amer. J. trop. Med. Hyg., 26: 186-187, 1977.

[8] 8. GOLDSMITH, E. I. & KEAN, B. H. Schistosomiasis: experimental surgical removal of adult worms. Gastroenterology, 50: 805-807, 1966.

[9] 9. GOLDSMITH, E. I.; LUZ, F. F. C.; PRATA, A. & KEAN, B. H. - Surgical recovery of schistosomes from the portal blood. Treatment of the parasitization in man. J. Amer. med. Ass., 199: 235-240, 1967.

[10] 10. GOODMAN, L. S. & GILMAN, A. The pharmacological basis of therapeutics 4th ed. London, MacMillan, 1970.

[11] 11. HILLYER, G. V. & LEWERT, R. M. Studies on renal pathology in hamsters infected with Schistosoma mansoni and Schistosoma japonicum. Amer. J. trop. Med. Hyg., 23: 404-411, 1974.

[12] 12. NATALI, P. J. & CIOLI, D. Immune complex nephritis in mice infected with Schistosoma mansoni. Fed. Proc., 33: 757, 1974.

[13] 13. PELLEGRINO, J. & SIQUEIRA, A. F. Técnica do perfusão para colheita de Schistosoma mansoni em cobaias experimentalmente infestadas. Rev. bras. Malar., 8: 589-597, 1956.

[14] 14. QUEIROZ, F. P.; BRITO, E.; MARTINELLI, R. & KOCHA, H. Nephrotic syndrome in patients with Schistosoma mansoni infection. Amer. J. trop. Med. Hyg., 22: 622-628, 1973.

[15] 15. SILVA, L. C.; BRITO, T.; CAMARGO, M. E.; DE BONI, D. R.; LOPES, J. D. & GUNJI, J. Kidney "biopsy in the hepatosplenic form of infection with Schistosoma mansoni in man. Bull. Wld. Hlth. Org., 42: 907-910, 1970.

[16] 16. VALADARES, T. E.; COELHO, P. M. Z. & SAMPAIO. I. B. M. Schistosoma mansoni: aspectos da oviposição (distribuição de ovos nos intestinos e fígado de camundongo e eliminação destes pelas fezes) das cepas LE e CA. Rev. bras. Malar., 32: 53-59, 1981.

[17] 17. WARREN, K. S. The immunopathogenesis of schistosomiasis: a multidisciplinary approach. Trans. roy Soc. trop. Med. Hyg., 66: 417-434, 1972.

Brasil

Brasil

Schistosoma mansoni: effects of anesthetics and antimonial drugs on worm shift in the mouse

Schistosoma mansoni: efeitos de anestésicos e antimonial (Triostib R) sobre o deslocamento de vermes no camundongo

Abstracts

Publication Dates